Abstract: A MDOF muscle training machine is provided in the present invention. The training machine has multi-degree-of-freedom (MDOF) being able to be set by users to make various cyclic motions with respect to various groups of muscle to be trained. The training machine comprises an adjustable frame and a cyclic motion device. The adjustable frame has MDOF being able to be adjusted with respect to the various cyclic motions. The cyclic motion device is assembled on the adjustable frame. The adjustable frame can be adjusted to decide a specific position of the cyclic motion device with respect to specific groups of muscle. Both arms (legs) of the user are constrained by the cyclic motion device. The user has to coordinate the specific groups of muscle to drive the cyclic motion device.