Abstract: A hinge mechanism comprises a follower, a cam and a first spring. The first spring is spiral, one end of the first spring is mounted to the follower, another end of the first spring is mounted to the cam. The cam rotates relative to the follower about a rotating axis, the first spring is compressed to accumulate elastic force, until the line connecting two ends of the first spring is parallel to the rotating axis where the first spring is mostly compressed to accumulate maximum of the elastic force and the hinge mechanism is in an intermediate state. Once the cam is rotated over the intermediate state, the first spring is expanded under previously accumulated elastic force, which drive the cam continuously rotated relative to the follower.

Abstract: A hinge mechanism comprises a follower, a cam and a first spring. The first spring is spiral, one end of the first spring is mounted to the follower, another end of the first spring is mounted to the cam. The cam rotates relative to the follower about a rotating axis, the first spring is compressed to accumulate elastic force, until the line connecting two ends of the first spring is parallel to the rotating axis where the first spring is mostly compressed to accumulate maximum of the elastic force and the hinge mechanism is in an intermediate state. Once the cam is rotated over the intermediate state, the first spring is expanded under previously accumulated elastic force, which drive the cam continuously rotated relative to the follower.

Abstract: This invention relates a process for preparing octreotide and derivatives thereof. The starting material, Thr(ol)(tBu)-2-chlorotrityl resin is coupled with the various amino acids. The straight peptide-resin of D-Phe-Cys(Trt)-Phe-D-Trp(Boc)-Lys(Boc)-Thr(tBu)-Cys(Trt)-Thr(ol)(tBu)-2-chlorotrityl resin or D-Phe-Cys(Trt)-Tyr(tBu)-D-Trp(Boc)-Lys(Boc)-Thr(tBu)-Cys(Trt)-Thr(ol)(tBu)-2-chlorotrityl resin was obtained. Cleavage of the peptide from the resin was achieved by strong acid solution.

Abstract: This invention is a novel synthesis of BCA-peptides (BCA: bifunctional chelating agents). In this method, the starting material--Fmoc-Thr(ol)-Terephthal-Acetal-Amide Resin is coupled with the various amino acids. The straight peptide-resin of D-Phe-Cys(Trt)-Phe-D-Trp(Boc)-Lys(Boc)-Thr(tBu)-Cys(Trt)-Thr(ol)-Terephtha l-Acetal-Amide Resin was obtained. This compound reacted with iodine to give disulfide-containing peptide resin of ##STR1## Cleavage of the peptide from the resin was achieved by TFA. The cleavaged peptide was protected by the reaction of octreotide with di-t-butyldicarbonate. BCA was coupled to the selectively protected octreotide. This product was obtained by reaction of protected BCA-peptides with TFA. The final product was labeled by radioisotope .sup.111 InCl.sub.3 for tumor imaging radiopharmaceuticals.