Patents by Inventor Tian-Shung Wu

Tian-Shung Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8197860
    Abstract: The present application relates to a method for enhancing absorption of a nutrient in a subject in need thereof with an effective amount of an isolated astragaloside compound.
    Type: Grant
    Filed: April 15, 2009
    Date of Patent: June 12, 2012
    Assignee: Nuliv Holding Inc.
    Inventors: Hang-Ching Lin, Wen-Liang Chang, Tsu-Chung Chang, Hsiou-Yu Ding, Tian Shung Wu
  • Patent number: 8188089
    Abstract: Compounds of Formula I are described: preferably subject to the proviso that either (a) R2 and R3 together form —O—CH(R10)—O—, or (b) R5 and R6 together form —O—CH(R10)—O—, wherein R10 is H, halo, or loweralkyl. Pharmaceutical salts, formulations, and methods of using the same in the treatment of cancer are also described.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: May 29, 2012
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Kuo-Hsiung Lee, Linyi Wei, Kenneth F. Bastow, Arnold Brossi, Tian-Shung Wu
  • Publication number: 20120015908
    Abstract: A compound of Formula I is disclosed as follows: or a pharmaceutically acceptable salt, prodrug, solvate, or metabolite thereof, wherein R is hydrogen, P(?O)(OH)2, P(?O)(O(C1-C18)alkylene(C6-C20)aryl)2, P(?O)(OH)(OM), P(?O)(OM)2, P?O(O2M), S(?O)(OH)2, S(?O)(O(C1-C18)alkylene(C6-C20)aryl)2, S(?O)(OH)(OM), S(?O)(OM)2; M is a monovalent or divalent metal ion, or alkylammonium ion; W is (C6-C20)aryl, (C6-C20)heteroaryl, (C1-C18)alkyl(C6-C20)aryl, (C1-C18)alkyl(C6-C20)heteroaryl, hydroxy(C6-C20)aryl, hydroxy(C6-C20)heteroaryl, (C1-C18)alkoxy(C6-C20)aryl, (C1-C18)alkoxy(C6-C20)heteroaryl, (C1-C18)alkylenedioxy(C6-C20)aryl, (C1-C18)alkylenedioxy(C6-C20)heteroaryl, halo(C6-C20)aryl, halo(C6-C20)heteroaryl, (C1-C18)alkylamino(C6-C20)aryl, (C1-C18)alkylamino(C6-C20)heteroaryl, (C1-C18)cycloalkylamino(C6-C20)aryl, or (C1-C18)cycloalkylamino(C6-C20)heteroaryl, and their OR8 substutes; R5 is (C1-C18alkoxy, hydrogen, hydroxyl, O—(C1-C18)alkyl(C6-C20)aryl, halo or OR8, or R5 and R6 are (C1-C18)dioxy provided that R7 i
    Type: Application
    Filed: July 13, 2011
    Publication date: January 19, 2012
    Applicant: Efficient Pharma Management Corporate
    Inventors: Sheng-Chu Kuo, Kuo-Hsiung Lee, Li-Jiau Huang, Li-Chen Chou, Tian-Shung Wu, Tzong-Der Way, Jing-Gung Chung, Jai-Sing Yang, Chi-Hung Huang, Meng-Tung Tsai
  • Publication number: 20110288061
    Abstract: The present invention relates to triterpenoid derivatives, benzenoid derivatives, and pharmaceutical compositions containing the same for treating cancers or inflammatory symptoms. According to the present invention, the triterpenoid derivatives and the benzenoid derivatives are respectively represented by the following formulas (I) and (II): wherein, R1, R2, R3, R4, R5, R6, R7, R8, R1?, R2?, R3?, and R4? are defined the same as the specification.
    Type: Application
    Filed: May 18, 2011
    Publication date: November 24, 2011
    Applicant: National Cheng Kung University
    Inventor: Tian-Shung Wu
  • Patent number: 7795299
    Abstract: Compounds of Formulas I-II are described, along with methods of using such compounds for the treatment of cancer and pharmaceutical formulations thereof.
    Type: Grant
    Filed: January 16, 2009
    Date of Patent: September 14, 2010
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Kuo-Hsiung Lee, Xihong Wang, Kenneth F. Bastow, Tian-Shung Wu
  • Publication number: 20100168064
    Abstract: 2-aryl-4-quinolones are converted into phosphates by reacting with tetrabenzyl pyrophosphate to form dibenzyl phosphates thereof, which are then subject to hydrogenation to replace dibenzyl groups with H, followed by reacting with Amberlite IR-120 (Na+ form) to form disodium salts. The results of preliminary screening revealed that these phosphates showed significant anti-cancer activity. A novel intermediate, 2-selenophene 4-quinolone and ?/, ?/-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones are also synthesized. These novel intermediates exhibited significant anticancer activities.
    Type: Application
    Filed: December 7, 2007
    Publication date: July 1, 2010
    Applicant: China Medical University
    Inventors: Sheng-Chu Kuo, Che-Ming Teng, Kuo-Hsiung Lee, Li-Jiau Huang, Li-Chen Chou, Chih-Shiang Chang, Chung-Ming Sun, Tian-Shung Wu, Shiow-Lin Pan, Tzong-Der Way, Jang-Chang Lee, Jing-Gung Chung, Jai-Sing Yang, Chien-Ting Chen, Ching-Che Huang, Shih-Ming Huang
  • Publication number: 20100099633
    Abstract: The present application relates to a method for enhancing absorption of a nutrient in a subject in need thereof with an effective amount of an isolated astragaloside compound.
    Type: Application
    Filed: April 15, 2009
    Publication date: April 22, 2010
    Applicant: NuLiv Holding Inc.
    Inventors: Hang-Ching Lin, Wen-Liang Chang, Tsu-Chung Chang, Hsiou-Yu Ding, Tian Shung Wu
  • Publication number: 20090181904
    Abstract: The present application relates to a method of regulating nutrient absorption in a subject in need thereof with an isolated ginsenoside compound.
    Type: Application
    Filed: December 29, 2008
    Publication date: July 16, 2009
    Applicant: NULIV HOLDING INC.
    Inventors: Hang-Ching Lin, Wen- Liang Chang, Tsu-Chung Chang, Hsiou-Yu Ding, Tian Shung Wu
  • Publication number: 20090124914
    Abstract: The present invention relates to an analysis system and method for pulse diagnosis in Chinese medicine, which analyzes quantitatively the variances of pulse condition, and in particular analyzes the “pulse POSITION”, “pulse PACE”, “pulse FORM” and “pulse DYNAMICS” elements in pulse condition with remarkable increase in the accuracy of pulse diagnosis. The analysis system for pulse diagnosis of the present invention comprises a pulse signal collecting device to collect and generate blood pressure and electrocardiogram signals; and a signal process unit to receive and analyze the blood pressure signal series and electrocardiogram signal series.
    Type: Application
    Filed: November 8, 2007
    Publication date: May 14, 2009
    Inventors: Terry B. J. Kuo, Cheryl C. H. Yang, Hsin-Yo Chen, Tian-Shung Wu, Hsien-Chang Wu
  • Patent number: 7531519
    Abstract: A polygalatenoside useful as an antidepressant agent having the formula is disclosed: wherein R, R? and R? independently are H or R1, provided that R, R? and R? are not all H, wherein R1 is wherein R2 is hydrogen, C1-C6 alkyl, C1-C6 alkoxy or halogen; or a pharmaceutically acceptable salt thereof. Preferably, R2 is H.
    Type: Grant
    Filed: September 21, 2006
    Date of Patent: May 12, 2009
    Assignee: Medical and Pharmaceutical Industry Technology and Development Center
    Inventors: Mo-Chi Cheng, Feng-Nien Ko, Tian-Shung Wu
  • Publication number: 20090118356
    Abstract: Compounds of Formulas I-II are described, along with methods of using such compounds for the treatment of cancer and pharmaceutical formulations thereof.
    Type: Application
    Filed: January 16, 2009
    Publication date: May 7, 2009
    Applicant: North Carolina State University
    Inventors: Kuo-Hsiung Lee, Xihong Wang, Kenneth F. Bastow, Tian-Shung Wu
  • Patent number: 7495026
    Abstract: Compounds of Formulas I-II are described, along with methods of using such compounds for the treatment of cancer and pharmeutical formulations thereof.
    Type: Grant
    Filed: March 9, 2005
    Date of Patent: February 24, 2009
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Kuo-Hsiung Lee, Xihong Wang, Kenneth F. Bastow, Tian-Shung Wu
  • Publication number: 20080300254
    Abstract: Compounds of Formula I are described: preferably subject to the proviso that either (a) R2 and R3 together form —O—CH(R10)—O—, or (b) R5 and R6 together form —O—CH(R10)—O—, wherein R10 is H, halo, or loweralkyl. Pharmaceutical salts, formulations, and methods of using the same in the treatment of cancer are also described.
    Type: Application
    Filed: December 20, 2006
    Publication date: December 4, 2008
    Inventors: Kuo-Hsiung Lee, Linyi Wei, Kenneth F. Bastow, Arnold Brossi, Tian-Shung Wu
  • Publication number: 20080076724
    Abstract: A polygalatenoside useful as an antidepressant agent having the formula is disclosed: wherein R, R? and R? independently are H or R1, provided that R, R? and R? are not all H, wherein R1 is wherein R2 is hydrogen, C1-C6 alkyl, C1-C6 alkoxy or halogen; or a pharmaceutically acceptable salt thereof. Preferably, R2 is H.
    Type: Application
    Filed: September 21, 2006
    Publication date: March 27, 2008
    Applicant: Medical and Pharmaceutical Industry Technology and Development Center
    Inventors: Mo-Chi Cheng, Feng-Nien Ko, Tian-Shung Wu
  • Publication number: 20050250751
    Abstract: Compounds of Formulas I-II are described, along with methods of using such compounds for the treatment of cancer and pharmeutical formulations thereof.
    Type: Application
    Filed: March 9, 2005
    Publication date: November 10, 2005
    Inventors: Kuo-Hsiung Lee, Xihong Wang, Kenneth Bastow, Tian-Shung Wu
  • Patent number: 6946153
    Abstract: A method of treating a patient suffering a disease associated with Trichophyton mentagrophytes or Pityrosporum ovale by applying topically an anti-fungal pharmaceutical composition which is prepared from Zingiber officinale, includes the following steps: preparing a crude liquid from rhizomes of ginger by extraction with an organic solvent or supercritical CO2, or by distillation with steam; introducing the crude liquid to a reverse phase chromatography column, and eluting the column with water, a first eluent and a second eluent having a polarity weaker than that of the first eluent but stronger than that of chloroform, so that a first eluate resulting from elution of the first eluent and a second eluate resulting from elution of the second eluent are obtained; removing the first eluent and the second eluent from the first eluate and the second eluate by evaporation, respectively, so that a first concentrated eluate and a second concentrated eluate are obtained as the potent extract.
    Type: Grant
    Filed: May 14, 2003
    Date of Patent: September 20, 2005
    Assignee: Medical and Pharmaceutical Industry Technology and Development Center
    Inventors: Tian-Shung Wu, Sheng-Chu Kuo, Che-Ming Teng, Feng-Nien Ko
  • Publication number: 20030203059
    Abstract: A method of preparing an extract which is potent in anti-fungal activity from Zingiber officinale, includes the following steps: preparing a crude liquid from rhizomes of ginger by extraction with an organic solvent or supercritical CO2, or by distillation with steam; introducing the crude liquid to a reverse phase chromatography column, and eluting the column with water, a first eluent and a second eluent having a polarity weaker than that of the first eluent but stronger than that of chloroform, so that a first eluate resulting from elution of the first eluent and a second eluate resulting from elution of the second eluent are obtained; removing the first eluent and the second eluent from the first eluate and the second eluate by evaporation, respectively, so that a first concentrated eluate and a second concentrated eluate are obtained as the potent extract.
    Type: Application
    Filed: May 14, 2003
    Publication date: October 30, 2003
    Applicant: Pharmaceutical Industry Technology and Development Center
    Inventors: Tian-Shung Wu, Sheng-Chu Kuo, Che-Ming Teng, Feng-Nien Ko
  • Publication number: 20020044979
    Abstract: A method of preparing an extract which is potent in anti-fungal activity from Zingiber officinale, includes the following steps: preparing a crude liquid from rhizomes of ginger by extraction with an organic solvent or supercritical CO2, or by distillation with steam; introducing the crude liquid to a reverse phase chromatography column, and eluting the column with water, a first eluent and a second eluent having a polarity weaker than that of the first eluent but stronger than that of chloroform, so that a first eluate resulting from elution of the first eluent and a second eluate resulting from elution of the second eluent are obtained; removing the first eluent and the second eluent from the first eluate and the second eluate by evaporation, respectively, so that a first concentrated eluate and a second concentrated eluate are obtained as the potent extract.
    Type: Application
    Filed: June 22, 2001
    Publication date: April 18, 2002
    Applicant: Pharmaceutical Industry Technology and development Center
    Inventors: Tian-Shung Wu, Sheng-Chu Kuo, Che-Ming Teng, Feng-Nien Ko
  • Patent number: 6274177
    Abstract: A method of preparing an extract from Zingiber officinale, which is potent in anti-inflammation and anti-platelet aggregation, includes the following steps: a) preparing a crude liquid from rhizomes of ginger by extraction with an organic solvent or by distillation with steam; b) introducing the crude liquid to a reverse phase chromatography column, and eluting the column with water, a first eluent and a second eluent having a polarity weaker than that of the first eluent but stronger than that of chloroform, so that a first eluate resulting from elution of the first eluent and a second eluate resulting from elution of the second eluent are obtained; c) removing the first eluent from the first eluate by evaporation, so that a first concentrated eluate is obtained and is able to used as the potent extract; and d) removing the second eluent from the second eluate by evaporation, so that a second concentrated eluate is obtained and is able to used as the potent extract.
    Type: Grant
    Filed: August 26, 2000
    Date of Patent: August 14, 2001
    Assignee: National Science Council
    Inventors: Tian-Shung Wu, Sheng-Chu Kuo, Che-Ming Teng, Feng-Nien Ko
  • Patent number: 5853731
    Abstract: A pharmaceutical composition which possesses vasorelaxing effect of aortic contraction, relaxing effect of tracheal contraction, and antioxidative properties, is disclosed. It contains a pharmaceutical acceptable vehicle and an effective amount of any compound selected from those compounds represented by the following formula: ##STR1## where R.sub.1 represents H, C.sub.1-8 alkyl, or --OCOR, R.sub.2 represents OH, or COO.sup.--, and R represents H, or C.sub.1-8 alkyl.
    Type: Grant
    Filed: April 29, 1997
    Date of Patent: December 29, 1998
    Assignee: National Science Council
    Inventors: Tian-Shung Wu, Che-Ming Teng, Sheu-Meei Yu