Abstract: The present invention discloses a lipid nanoparticle (LNP) and its application, comprising cationic ionisable lipids, auxiliary lipids, ligand-modified PEGylated lipids, and cholesterol. The auxiliary lipids and ligand-modified PEGylated lipids target receptors on the surface of liver sinusoidal endothelial cells (LSECs). The LNPs enhance LSEC-specific uptake through a targeted design involving the lipid-specific interaction pathway.

Abstract: A computer-implemented method of training a causal generative model for counterfactual medical image generation includes obtaining medical imaging data including images depicting anatomy of patients and associated causal parameters, obtaining a causal generative model with structural causal functions defining relationships between causal parameters, an encoder network, and a decoder network, and iteratively determining latent parameter noise and a latent representation, obtaining spatially targeted interventions, generating counterfactual parameters and a counterfactual image, determining a loss by applying a pre-trained segmentor to obtain segmentation outputs, determining the loss based on the difference between measurements and counterfactual parameters, and updating the causal generative model.

Abstract: A scheduling method of a data prefetcher for handling indirect accesses, including the steps of: S100: constructing a data prefetcher that handles irregular accesses; S200: implementing, with the data prefetcher, identification of an indirect access pattern and address prediction based on differential matching between index data and an indirect access address, and dividing indirect accesses into different range groups to perform prefetch scheduling according to the range groups. The method enhances the timeliness of prefetched data, improves the accuracy of data prefetching, and increases the coverage rate. Moreover, the method boasts an extremely low hardware resource overhead.

Abstract: A differential matching prefetcher for coping with irregular memory access includes: an access index table, an access target table, a differential matching module, an index queue, an indirect memory access candidate scoreboard, an address generator, an indirect memory access relationship table, a prefetch status handling register, a repetition filter, a continuous address filter, and a range prefetch table. The differential matching prefetcher is configured to monitor events of access requests and data responses between a computing core and a first level of cache, as well as between the first level of cache and a second level of cache. The differential matching prefetcher may be applied in various general-purpose computing architectures adopting a hierarchical storage design to realize mode capture and data prefetch for irregular indirect memory access, reduce long-delay storage access overhead caused by the irregular memory access, and increase instructions per cycle (IPC) of the computing architectures.

Abstract: Disclosed are a method and a circuit for implementing a two-qubit gate, a quantum device, and a quantum chip. The method includes: applying a first quantum control signal to a first data qubit; applying a second quantum control signal to a second data qubit; and activating, by means of adjusting the first quantum control signal and the second quantum control signal, longitudinal coupling between the first data qubit and the second data qubit within a predetermined time, so as to implement the two-qubit gate. The present disclosure solves the technical problem in the related art of low precision of the two-qubit gate.

Abstract: Apparatuses, systems, and techniques to assess labeling of objects within an image. In at least one embodiment, objects are labeled in an image and then said labeling is assessed based, at least in part, on one or more prior assessments of the one or more unlabeled objects.

Abstract: An electrophoretic display panel includes a first substrate, electrophoretic particles, a scan line, a data line, and a pixel. The scan line, the data line, and the pixel are located on the same side of the first substrate facing the electrophoretic particles. The scan line is configured to transmit a scan signal to the pixel. The data line is configured to transmit a data signal to the pixel, and a data signal includes multiple unit periods. In a write state in a drive stage of the electrophoretic display panel, the data signal includes a drive signal and at least one adjustment signal inserted into the drive signal and configured to divide the drive signal into at least two drive sub-signals, and a voltage of a drive sub-signal of the at least two drive sub-signal is different from a voltage of an adjustment signal in a unit period.

Abstract: An electrical sensor assembly includes an electrical plug housing for mating a mating connector, a circuit board in the plug housing, a plurality of terminals which make electrical contact to a surface of the circuit board, and a sensor on the circuit board in electrical contact with a plurality of electrical connectors on the surface of the circuit board. The electrical connectors press against the respective terminals for making the electrical contact. A sensor arrangement can include the electrical sensor assembly and a mating connector that connects to the electrical plug housing. The mating connector includes a plurality of complementary terminals that electrically connect to the terminals.

Abstract: Methods of controlling movements of a mobile robot having a mobility system for moving the mobile robot in a deployment environment, the mobility system being responsive to a plurality of movement commands. In an example of such methods, the method includes: providing, by a headset of an augmented-reality system to a user wearing the headset, a view of features within the deployment environment; capturing, by a first camera of the augmented-reality system, a first gesture that the user makes with the hand; translating the first gesture into at least one of the movement commands; and transmitting the at least one of the movement commands to the mobile robot. Related systems, software, and apparatuses are also disclosed.

Abstract: A method for constructing a clinically-relevant large animal model of traumatic optic neuropathy, employing a goat with orbital anatomy and optic nerve structure similar to humans as a model animal, overing the defects existing in other animals as TON model animals. The target model goat is obtained by screening parameters, such as a maximum transverse diameter of a coronal plane of a body of sphenoid bone and a wall width of a sphenoid bone, thereby facilitating the exposure of an optic nerve in a optic-canal segment under a nasal endoscopic surgery and quantitative injury. With the optic nerve injury animal model, the clinical TON pathogenesis can be explored by studying the optic nerve at the injured optic canal. In the prepared TON animal model, the injured optic nerve is closer to the brain, which is beneficial to rebuilding the synaptic connection.

Abstract: The invention relates to a modified polyisocyanate and use thereof, especially as a crosslinking component in a water-soluble or water-dispersible coating composition. The modified polyisocyanate comprises iminooxadiazinedione structure and isocyanurate structure, wherein the weight ratio of the iminooxadiazinedione structure to the isocyanurate structure is not less than 1:5; and relative to the total weight of the modified polyisocyanate, the total amount of molecules with a number average molecular weight greater than 2700 g/mol in the modified polyisocyanate is 4.1% by weight to 22% by weight; and the modified polyisocyanate is obtainable by the reaction of: an aminosulfonic acid, a polyisocyanate; a tertiary amine; and optionally a polyether alcohol containing ethylene oxide groups.

Abstract: A method of generating a physical unclonable function (PUF) key uses a value read from an array of bitcells in rows defined by pairs of true and complement wordlines and columns defined by pairs of true and complement bitlines, each bitcell having a pull-up network coupled to a complement wordline and to the true and complement bitlines, and having a pull-down network coupled to a true wordline and to the true and complement bitlines. A pull-up network of a first bitcell is activated by the complement wordline. A pull-down network of a second bitcell is activated by the true wordline. A first value based on the pull-up network of the first bitcell and the pull-down network of the second bitcell is read using a sense amplifier coupled to a true bitline and a complement bitline. A PUF key is generated using the first value.

Abstract: A method of operating a chip as an entropy source for generating a physical unclonable function (PUF) key includes: arranging in the chip a pre-amplifier array of bitcells in respective rows defined by respective pairs of true and complement wordlines and in columns defined by respective pairs of true and complement bitlines; reading, by a sense amplifier, a preferred state from a bitcell along a selected pair of the pairs of true and complement wordlines, where the pre-amplifier array of bitcells comprises the bitcell; performing feedback-reinforced accelerated aging via control circuitry in the chip including, based on the read preferred state, applying a stress condition that causes an accelerated aging effect including biasing the bitcell to the preferred state to reinforce the preferred state in the bitcell; subsequent to performing the feedback-reinforced accelerated aging, reading a value from the bitcell; and generating a PUF key using the value.

Abstract: A computer implemented method for training a whole medical image foundation model, including: receiving a plurality of medical image datasets; extracting local sections of image data from the plurality of medical image datasets; obtaining one or more causal variables associated with the local sections and/or patient; training one or more self-supervised learning models based on the local sections of image data and the causal variables; combining the one or more trained self-supervised learning models with a deep learning network configured to combine a latent representation of the local sections of image data from the one or more trained self-supervised learning models into a patient-level representation; and combining, with the one or more trained self-supervised learning models and the deep learning network, at least one further network or function configured to accept the patient-level representation as input, the at least one further network or function operable to perform one or more patient-specific pre

Abstract: The invention relates to a water-dispersible modified polyisocyanate and use thereof, especially as a crosslinking component in water-soluble or water-dispersible coating compositions. The water-dispersible modified polyisocyanate can be obtained by the reaction of a system comprising a water-dispersible polyisocyanate and an isocyanate-reactive component; wherein the viscosity of the water-dispersible modified polyisocyanate is 3000 mPa·s-11000 mPa·s, which is measured with a MV-DIN rotor according to DIN EN ISO 3219:1994-10 at 23° C. and a shear rate of 10 s?1. The modified polyisocyanate according to the present invention has good manual stirring behavior and good dispersibility, and the coating formed by the coating composition containing the modified polyisocyanate has high gloss and good transparency.

Abstract: In various embodiments tolerogenic nanoparticles are provided that induce immune tolerance to one or more desired antigen(s) and/or that reduce an immune response to those antigen(s). In certain embodiments the tolerogenic nanoparticle comprises a nanoparticle comprising a biocompatible polymer; an antigen disposed within or attached to said biocompatible polymer where said antigen comprises an antigen to which immune tolerance is to be induced by administration of said tolerogenic nanoparticle to a mammal; and a first targeting moiety that binds to a scavenger receptor in the liver, and/or a second targeting moiety that binds to a mannose receptor in the liver, and/or a third targeting moiety that binds to hepatocytes, wherein said first and/or second and/or third targeting moiety are attached to the surface of said nanoparticle.

Abstract: Disclosed are a method and a circuit for implementing a two-qubit gate. The method includes: applying a coupling control signal to an adjustable coupler, wherein the adjustable coupler is a coupler between a first data qubit and a second data qubit; and activating, by means of adjusting the coupling control signal, longitudinal coupling between the first data qubit and the second data qubit within a predetermined time, so as to implement the two-qubit gate. The present disclosure solves the technical problem in the related art of low precision of the two-qubit gate.

Abstract: Submersible testing units (STUs) that each include either one or more sample chambers for acquiring one or more samples, e.g., from a body of water, or one or more submersible sensors for acquiring sensor data, e.g., from the body of water, or both one or more sample chambers and one or more submersible sensors. In some embodiments, an STU includes multiple sample chambers that can be opened and closed independently of one another. In some embodiments, an STU having one or more submersible sensors is part of an STU deployment system that transmits sensor data to a data-collection node in real time while the one or more submersible sensors are submerged. Related components, systems, methods, and software are also disclosed.

Abstract: 2-aminopyrimidine compounds and pharmaceutical compositions and uses thereof are provided. Specifically, the 2-aminopyrimidine compounds have a structure as shown in formula I. The compounds are suitable for use in the fields of anti-virus and anti-infection, as well as treatment of diseases such as autoimmune diseases and tumors.

Abstract: Mobile sensing robots having multipoint sensing systems that include multiple probes for making measurements of material characteristics and/or other conditions. The probes may be deployed on traction elements, such as legs, wheels, and/or tracks, of a traction system that can move the robot on a surface of a material. The probes may be deployed on a probe deployment system that operates independently of any traction system provided. The mobile sensing robot may include a mobility system, such as an aerial mobility system and/or a submissible mobility system, in addition to or in place of the traction system. The probes may be of any one or more of a variety of types, such as vibration-sensing probes, stimulus electrode, measuring electrodes, temperature sensors, and humidity sensors, among many other types.