Patents by Inventor Tian-Xian Zhao

Tian-Xian Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220003790
    Abstract: The present invention relates to sample analysis cartridges comprising micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using micro-environment sensors in a point of care sample analysis cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample, and a conduit fluidically connected to the inlet chamber and configured to receive the biological sample from the inlet chamber. The conduit may include a micro-environment prothrombin time (PT) sensor, and a micro-environment activated partial thromboplastin time (aPTT) sensor.
    Type: Application
    Filed: September 15, 2021
    Publication date: January 6, 2022
    Applicant: Abbott Point of Care Inc.
    Inventors: Tian-Xian Zhao, Anjulia Chiu-Yuk Wong, Glenn Brian Martin, Katrina Petronilla Di Tullio, Isabelle Louisette Thibodeau, Steven Roy Breeze, Smitha RK Sutrala, Eric Hong, Jay Kendall Taylor, Sheila Diane Ball
  • Patent number: 11156620
    Abstract: The present invention relates to sample analysis cartridges comprising micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using micro-environment sensors in a point of care sample analysis cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample, and a conduit fluidically connected to the inlet chamber and configured to receive the biological sample from the inlet chamber. The conduit may include a micro-environment prothrombin time (PT) sensor, and a micro-environment activated partial thromboplastin time (aPTT) sensor.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: October 26, 2021
    Assignee: Abbott Point of Care Inc.
    Inventors: Tian-Xian Zhao, Anjulia Chiu-Yuk Wong, Glenn Brian Martin, Katrina Petronilla Di Tullio, Isabelle Louisette Thibodeau, Steven Roy Breeze, Smitha R K Sutrala, Eric Hong, Jay Kendall Taylor, Sheila Diane Ball
  • Patent number: 10514354
    Abstract: The present invention relates to analytical testing devices and methods for fabricating electrochemical creatinine biosensors, and in particular using point of care electrochemical biosensors for testing for creatinine in samples. For example, the present invention may be directed to a biosensor having an electrode, a first printed layer formed on the electrode and having a first matrix that includes creatinine amidohydrolase (CNH), creatine amidinohydrolase (CRH), and sarcosine oxidase (SOX), and second printed layer formed over the first printed layer and having a second matrix that includes CRH, SOX, and catalase.
    Type: Grant
    Filed: October 5, 2016
    Date of Patent: December 24, 2019
    Assignee: Abbott Point of Care Inc.
    Inventors: Tian-Xian Zhao, Glenn Martin, Kenneth Hardage, Steven R. Breeze, Stephen Snyder
  • Patent number: 10473612
    Abstract: The present invention relates to analytical testing devices comprising a resistor for cartridge device identification and methods for assaying coagulation in a fluid sample based on the cartridge device identification, and in particular, to performing coagulation assays using a resistor for cartridge device identification in a point of care test cartridge. For example, the present invention may be directed to a chip including an analyte electrode connected to a first connection pin, a reference electrode connected to a second connection pin, and a resistor connected to the second connection pin and a third connection pin.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: November 12, 2019
    Assignee: Abbott Point of Care Inc.
    Inventors: Jay Kendall Taylor, Tian-Xian Zhao, Sheila Diane Ball, Kenneth Harold Hardage, Steven Roy Breeze, Joshua David Newlands
  • Patent number: 10352951
    Abstract: The present invention relates to analytical testing devices including micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, performing one or more types of coagulation assays using one or more micro-environment sensors in a single point of care combined test cartridge. For example, the present invention may be directed to test sensor including at least one transducer coated with a polymer layer. The polymer layer comprises a thrombin-cleavable peptide with a detectable moiety.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: July 16, 2019
    Assignee: Abbott Point of Care Inc.
    Inventors: Tian-Xian Zhao, Anjulia Chiu-Yuk Wong, Glenn Brian Martin, Katrina Petronilla Di Tullio, Isabelle Louisette Thibodeau, Steven Roy Breeze, Smitha R K Sutrala, Eric Hong, Sheila Diane Ball
  • Publication number: 20190154710
    Abstract: The present invention relates to sample analysis cartridges comprising micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using micro-environment sensors in a point of care sample analysis cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample, and a conduit fluidically connected to the inlet chamber and configured to receive the biological sample from the inlet chamber. The conduit may include a micro-environment prothrombin time (PT) sensor, and a micro-environment activated partial thromboplastin time (aPTT) sensor.
    Type: Application
    Filed: January 28, 2019
    Publication date: May 23, 2019
    Applicant: Abbott Point of Care Inc.
    Inventors: Tian-Xian Zhao, Anjulia Chiu-Yuk Wong, Glenn Brian Martin, Katrina Petronilla Di Tullio, Isabelle Louisette Thibodeau, Steven Roy Breeze, Smitha RK Sutrala, Eric Hong, Jay Kendall Taylor, Sheila Diane Ball
  • Patent number: 10247741
    Abstract: The present invention relates to sample analysis cartridges comprising micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using micro-environment sensors in a point of care sample analysis cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample, and a conduit fluidically connected to the inlet chamber and configured to receive the biological sample from the inlet chamber. The conduit may include a micro-environment prothrombin time (PT) sensor, and a micro-environment activated partial thromboplastin time (aPTT) sensor.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: April 2, 2019
    Assignee: Abbott Point of Care Inc.
    Inventors: Tian-Xian Zhao, Anjulia Chiu-Yuk Wong, Glenn Brian Martin, Katrina Petronilla Di Tullio, Isabelle Louisette Thibodeau, Steven Roy Breeze, Smitha RK Sutrala, Eric Hong, Jay Kendall Taylor, Sheila Diane Ball
  • Patent number: 10188327
    Abstract: The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: January 29, 2019
    Assignee: Abbott Point of Care Inc.
    Inventors: Gary Vandersleen, Pierre Emeric, Paul Wasserman, Narendra Soman, Graham Davis, Tian-Xian Zhao, Paul Glavina
  • Patent number: 10186174
    Abstract: Methods and devices for determining device usability, e.g., for point of care assay devices. In one embodiment, the invention is to a method of determining device usability in a sensing device, including the steps of: providing a device comprising a first electrical pad; a second electrical pad; and a first polymer layer contacting at least a portion of the first and the second electrical pads and a second polymer layer contacting the first polymer layer and not the first and second electrical pads; applying a potential across the first and the second electrical pads; measuring an electrical property associated with the first and the second polymer layers; and determining whether the measured electrical property associated with the first and the second polymer layers has exceeded a threshold level associated with the device usability.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: January 22, 2019
    Assignee: Abbott Point of Care Inc.
    Inventors: Glenn Martin, Tian-Xian Zhao, Stephen L. Snyder
  • Publication number: 20180184955
    Abstract: The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof.
    Type: Application
    Filed: February 28, 2018
    Publication date: July 5, 2018
    Applicant: Abbott Point of Care Inc.
    Inventors: Gary Vandersleen, Pierre Emeric, Paul Wasserman, Narendra Soman, Graham Davis, Tian-Xian Zhao, Paul Glavina
  • Publication number: 20180164331
    Abstract: The present invention relates to analytical testing devices including micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, performing one or more types of coagulation assays using one or more micro-environment sensors in a single point of care combined test cartridge. For example, the present invention may be directed to test sensor including at least one transducer coated with a polymer layer. The polymer layer comprises a thrombin-cleavable peptide with a detectable moiety.
    Type: Application
    Filed: January 25, 2018
    Publication date: June 14, 2018
    Applicant: Abbott Point of Care Inc.
    Inventors: Tian-Xian Zhao, Anjulia Chiu-Yuk Wong, Glenn Brian Martin, Katrina Petronilla Di Tullio, Isabelle Louisette Thibodeau, Steven Roy Breeze, Smitha RK Sutrala, Eric Hong, Sheila Diane Ball
  • Patent number: 9949674
    Abstract: The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: April 24, 2018
    Assignee: Abbott Point of Care Inc.
    Inventors: Gary Vandersleen, Pierre Emeric, Paul Wasserman, Narendra Soman, Graham Davis, Tian-Xian Zhao, Paul Glavina
  • Publication number: 20180075782
    Abstract: Methods and devices for determining device usability, e.g., for point of care assay devices. In one embodiment, the invention is to a method of determining device usability in a sensing device, including the steps of: providing a device comprising a first electrical pad; a second electrical pad; and a first polymer layer contacting at least a portion of the first and the second electrical pads and a second polymer layer contacting the first polymer layer and not the first and second electrical pads; applying a potential across the first and the second electrical pads; measuring an electrical property associated with the first and the second polymer layers; and determining whether the measured electrical property associated with the first and the second polymer layers has exceeded a threshold level associated with the device usability.
    Type: Application
    Filed: September 13, 2017
    Publication date: March 15, 2018
    Inventors: Glenn Martin, Tian-Xian Zhao, Stephen L. Snyder
  • Patent number: 9903877
    Abstract: The present invention relates to analytical testing devices including micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, performing one or more types of coagulation assays using one or more micro-environment sensors in a single point of care combined test cartridge. For example, the present invention may be directed to test sensor including at least one transducer coated with a polymer layer. The polymer layer comprises a thrombin-cleavable peptide with a detectable moiety.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: February 27, 2018
    Assignee: Abbott Point of Care Inc.
    Inventors: Tian-Xian Zhao, Anjulia Chiu-Yuk Wong, Glenn Brian Martin, Katrina Petronilla Di Tullio, Isabelle Louisette Thibodeau, Steven Roy Breeze, Smitha R K Sutrala, Eric Hong, Sheila Diane Ball
  • Patent number: 9792838
    Abstract: Methods and devices for determining device usability, e.g., for point of care assay devices. In one embodiment, the invention is to a method of determining device usability in a sensing device, including the steps of: providing a device comprising a first electrical pad; a second electrical pad; and a first polymer layer contacting at least a portion of the first and the second electrical pads and a second polymer layer contacting the first polymer layer and not the first and second electrical pads; applying a potential across the first and the second electrical pads; measuring an electrical property associated with the first and the second polymer layers; and determining whether the measured electrical property associated with the first and the second polymer layers has exceeded a threshold level associated with the device usability.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: October 17, 2017
    Assignee: Abbott Point of Care Inc.
    Inventors: Glenn Martin, Tian-Xian Zhao, Stephen Lee Snyder
  • Publication number: 20170023514
    Abstract: The present invention relates to analytical testing devices and methods for fabricating electrochemical creatinine biosensors, and in particular using point of care electrochemical biosensors for testing for creatinine in samples. For example, the present invention may be directed to a biosensor having an electrode, a first printed layer formed on the electrode and having a first matrix that includes creatinine amidohydrolase (CNH), creatine amidinohydrolase (CRH), and sarcosine oxidase (SOX), and second printed layer formed over the first printed layer and having a second matrix that includes CRH, SOX, and catalase.
    Type: Application
    Filed: October 5, 2016
    Publication date: January 26, 2017
    Inventors: Tian-Xian Zhao, Glenn Martin, Kenneth Hardage, Steven R. Breeze, Stephen Snyder
  • Patent number: 9487811
    Abstract: The present invention relates to analytical testing devices and methods for fabricating electrochemical creatinine biosensors, and in particular using point of care electrochemical biosensors for testing for creatinine in samples. For example, the present invention may be directed to a biosensor having an electrode, a first printed layer formed on the electrode and having a first matrix that includes creatinine amidohydrolase (CNH), creatine amidinohydrolase (CRH), and sarcosine oxidase (SOX), and second printed layer formed over the first printed layer and having a second matrix that includes CRH, SOX, and catalase.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: November 8, 2016
    Assignee: Abbott Point of Care Inc.
    Inventors: Tian-Xian Zhao, Glenn Martin, Kenneth Hardage, Steven R. Breeze, Stephen Snyder
  • Publication number: 20160091455
    Abstract: The present invention relates to analytical testing devices comprising a resistor for cartridge device identification and methods for assaying coagulation in a fluid sample based on the cartridge device identification, and in particular, to performing coagulation assays using a resistor for cartridge device identification in a point of care test cartridge. For example, the present invention may be directed to a chip including an analyte electrode connected to a first connection pin, a reference electrode connected to a second connection pin, and a resistor connected to the second connection pin and a third connection pin.
    Type: Application
    Filed: September 25, 2015
    Publication date: March 31, 2016
    Inventors: Jay Kendall Taylor, Tian-Xian Zhao, Sheila Diane Ball, Kenneth Harold Hardage, Steven Roy Breeze, Joshua David Newlands
  • Publication number: 20160091507
    Abstract: The present invention relates to analytical testing devices including micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, performing one or more types of coagulation assays using one or more micro-environment sensors in a single point of care combined test cartridge. For example, the present invention may be directed to test sensor including at least one transducer coated with a polymer layer. The polymer layer comprises a thrombin-cleavable peptide with a detectable moiety.
    Type: Application
    Filed: September 25, 2015
    Publication date: March 31, 2016
    Inventors: Tian-Xian Zhao, Anjulia Chiu-Yuk Wong, Glenn Brian Martin, Katrina Petronilla Di Tullio, Isabelle Louisette Thibodeau, Steven Roy Breeze, Smitha RK Sutrala, Eric Hong, Sheila Diane Ball
  • Publication number: 20160091508
    Abstract: The present invention relates to sample analysis cartridges comprising micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using micro-environment sensors in a point of care sample analysis cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample, and a conduit fluidically connected to the inlet chamber and configured to receive the biological sample from the inlet chamber. The conduit may include a micro-environment prothrombin time (PT) sensor, and a micro-environment activated partial thromboplastin time (aPTT) sensor.
    Type: Application
    Filed: September 25, 2015
    Publication date: March 31, 2016
    Inventors: Tian-Xian Zhao, Anjulia Chiu-Yuk Wong, Glenn Brian Martin, Katrina Petronilla Di Tullio, Isabelle Louisette Thibodeau, Steven Roy Breeze, Smitha RK Sutrala, Eric Hong, Jay Kendall Taylor, Sheila Diane Ball