Abstract: The disclosure relates to the field of medicinal chemistry. Disclosed are a 14-chloro-?-elemene nitric oxide donor derivative and a preparation method and use thereof in the preparation of anti-tumor drugs. The 14-chloro-?-elemene nitric oxide donor derivative has a general formula shown in formula (I): in formula (I): R1 represents a linear or cyclic alcohol amine structure containing nitrogen and oxygen atoms; and each of R2 and R3 is independently selected from the group consisting of C1-10 alkyl, C3-12 cycloalkyl, C6-12 aryl, 5- to 10-membered cyclic heteroaryl, C2-10 alkenyl, C2-10 alkynyl, and C2-10 alkoxy.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: A method for extracting and isolating a lutein crystal from a vegetable oil resin containing a lutein diester, comprises: dissolving lipase into deionized water to form an enzyme solution; dissolving a lutein extract into an alcohol solvent containing the deionized water to form a uniform alcohol solution; adding the enzyme solution to the alcohol solution for performing hydrolysis, and stirring same to obtain a lutein solution; filtering and performing filtration isolation on the lutein solution to obtain a crystalline; re-dissolving the crystalline into a non-polar organic solvent, and using deionized water for washing a water-soluble impurity; recycling and cooling the organic solvent to obtain a recrystallization; and isolating and drying the recrystallization to obtain the lutein crystal. In this method, selectivity is strong, reaction time is short, no waste water is produced, process is environment-friendly and suitable for industrial production, and obtained lutein crystal is high in purity and yield.

Abstract: Disclosed are an input device and a surgical robot. The input device includes a mounting base, a rotation support, a grip mechanism, a connection member, a magnetic element and at least one first detection component. The rotation support is rotatable around a first central axis relative to the mounting base. The grip mechanism is disposed on the rotation support, and is transitionable between an open position and a close position. The connection member is connected with the grip mechanism, and is movable in a direction substantially parallel to the first central axis with opening and closing of the grip mechanism. The magnetic element is disposed on the rotation support or the connection member. The at least one first detection component is disposed on the mounting base, and is configured to detect a magnetic field direction of the magnetic element.

Abstract: A conversation engine performs conversations with users using chatbots customized for performing a set of tasks that can be performed using an online system. The conversation engine loads a chatbot configuration that specifies the behavior of a chatbot including the tasks that can be performed by the chatbot, the types of entities relevant to each task, and so on. The conversation may be voice based and use natural language. The conversation engine may load different chatbot configurations to implement different chatbots. The conversation engine receives a conversation engine configuration that specifies the behavior of the conversation engine across chatbots. The system may be a multi-tenant system that allows customization of the chatbots for each tenant.

Abstract: A conversation engine performs conversations with users using chatbots customized for performing a set of tasks that can be performed using an online system. The conversation engine loads a chatbot configuration that specifies the behavior of a chatbot including the tasks that can be performed by the chatbot, the types of entities relevant to each task, and so on. The conversation may be voice based and use natural language. The conversation engine may load different chatbot configurations to implement different chatbots. The conversation engine receives a conversation engine configuration that specifies the behavior of the conversation engine across chatbots. The system may be a multi-tenant system that allows customization of the chatbots for each tenant.

Abstract: A multi-tenant system performs custom configuration of a tenant-specific chatbot to process and act upon natural language requests. The multi-tenant system configures the tenant-specific chatbots without requiring tenant-specific training. The multi-tenant system providing a user interface for configuring a tenant-specific set of permitted actions. The multi-tenant system determines a set of example phrases for each of the selected permitted actions. The multi-tenant system receives a natural language request from a user and identifies the action that the user wants to perform. The multi-tenant system uses a neural network to compare the natural language request with example phrases to identify an example phrase that matches the natural language request. The multi-tenant system performs the action corresponding to the matching example phrase.

Abstract: An online system that allows users to interact with it using expressions in natural language form includes an intent inference module allowing it to infer an intent represented by a user expression. The intent inference module has a set of possible intents, along with a small set of example natural language expressions known to represent that intent. When a user interacts with the system using a natural language expression for which the intent is not already known, the intent inference module applies a natural language inference model to compute scores indicating whether the user expression textually entails the various example natural language expressions. Based on the scores, the intent inference module determines an intent that is most applicable for the expression. If an intent cannot be determined with sufficient confidence, the intent inference module may further attempt to determine whether the various example natural language expressions textually entail the user expression.

Abstract: A conversation engine performs conversations with users using chatbots customized for performing a set of tasks that can be performed using an online system. The conversation engine loads a chatbot configuration that specifies the behavior of a chatbot including the tasks that can be performed by the chatbot, the types of entities relevant to each task, and so on. The conversation may be voice based and use natural language. The conversation engine may load different chatbot configurations to implement different chatbots. The conversation engine receives a conversation engine configuration that specifies the behavior of the conversation engine across chatbots. The system may be a multi-tenant system that allows customization of the chatbots for each tenant.

Abstract: A system performs conversations with users using chatbots customized for performing a set of tasks. The system may be a multi-tenant system that allows customization of the chatbots for each tenant. The system receives a task configuration that maps tasks to entity types and an entity configuration that specifies methods for determining entities of a particular entity type. The system receives a user utterance and determines the intent of the user using an intent detection model, for example, a neural network. The intent represents a task that the user is requesting. The system determines one or more entities corresponding to the task. The system performs tasks based on the determined intent and the entities and performs conversations with users based on the tasks.

Abstract: Database systems and methods are provided for assigning structural metadata to records and creating automations using the structural metadata. One method of assigning structural metadata to a record associated with a conversation involves obtaining a plurality of utterances associated with the conversation, identifying, from among the plurality of utterances, a representative utterance for semantic content of the conversation, assigning the conversation to a group of semantically similar conversations based on the representative utterance, and automatically updating the record associated with the conversation at a database system to include metadata identifying the group of semantically similar conversations.

Abstract: The invention discloses a method for determining dynamic wetland boundary based on hydrology, organism and soil elements, including the following steps: step 1: extracting dynamic wetland hydrology boundary; step 2: obtaining data on wetland vegetation; step 3: obtaining data on wetland soil; step 4: simulating dynamic wetland vegetation boundary and dynamic wetland soil boundary according to the data from step 1 to step 3; step 5: determining dynamic wetland boundary; the invention can reflect the dynamic wetland boundary in multiple dimensions comprehensively and accurately.

Abstract: Database systems and methods are provided for assigning structural metadata to records and creating automations using the structural metadata. One method of assigning structural metadata to a group of records involves determining, based on one or more fields of metadata associated with the records, a plurality of candidate names, wherein each candidate name of the plurality of candidate names corresponds to semantic content of the one or more fields of a respective record of the group of records, for each candidate name, assigning a name relevance score based on respective word relevance scores assigned to respective words of the respective candidate name based on usage, selecting a candidate name in a manner that is influenced by the respective name relevance scores assigned to the respective candidate names and automatically assigning a name to the group of records using the candidate name.

Abstract: A system authenticates users using voice-based conversations. The system allows the authentication process to be customized using an authentication plan. For example, the system may be a multi-tenant system that allows customization of the authentication process for each tenant. The authentication plan is represented as an expression of phrase types, each phrase type associated with a phrase verification method. The system authenticates a user by executing the expression of an authentication plan for that user in response to a request from the user. The system performs a conversation with the user according to the authentication plan. The system determines whether to allow or deny the user request based on the result of evaluation of the expression of the authentication plan.

Abstract: A conversation engine performs conversations with users using chatbots customized for performing a set of tasks that can be performed using an online system. The conversation engine loads a chatbot configuration that specifies the behavior of a chatbot including the tasks that can be performed by the chatbot, the types of entities relevant to each task, and so on. The conversation may be voice based and use natural language. The conversation engine may load different chatbot configurations to implement different chatbots. The conversation engine receives a conversation engine configuration that specifies the behavior of the conversation engine across chatbots. The system may be a multi-tenant system that allows customization of the chatbots for each tenant.

Abstract: A system performs conversations with users using chatbots customized for performing a set of tasks. The system may be a multi-tenant system that allows customization of the chatbots for each tenant. The system processes sentences that may include negation or coreferences. The system determines a confidence score for an input sentence using an intent detection model, for example, a neural network. The system modifies the sentence to generate a modified sentence, for example, by removing a negation or by replacing a pronoun with an entity. The system generates a confidence score for the modified sentence using the intent detection model. The system determines the intent of the sentence based on the confidence scores of the sentence and the modified sentence. The system performs tasks based on the determined intent and performs conversations with users based on the tasks.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: The present invention extends to methods, systems, and computer program products for testing proximity card readers. Aspects include proximity card reader test bed environments configured to test proximity card readers with a plurality of proximity cards while minimizing human involvement. A proximity card reader can be tested to determine a likelihood of the proximity card reader functioning as intended over time and to determine proximity card reader compatibility with different proximity card formats. Proximity card reader failures (e.g., crashes) and incompatibilities can be detected in the testbed environment reducing the likelihood of deploying defective and/or incompatible card readers into operation.

Abstract: Systems and methods for providing a microwave-to-optical (M2O) transducer using magneto-optical field interactions with spin states of an ensemble of ions doped into a crystal structure is presented. According to one aspect, the crystal structure is a (171Yb3+:YVO) doped crystal structure that provides a substrate for an on-chip implementation of the transducer. According to one aspect, coupling of microwave and optical signals to the ions is based on respective microwave and optical waveguides fabricated in or on the doped crystal structure. According to another aspect, coupling of microwave and optical signals to the ions is based on respective microwave and optical resonant cavities fabricated in or on the doped crystal structure. Transduction can be based on either a three-level system with near-zero applied external magnetic field or on a four-level system with zero applied external magnetic field. The transducer can operate reversibly as an optical-to-microwave (O2M) transducer.

Abstract: The present invention provides a preparation method for a carotenoid preparation having high bioavailability and high stability, comprising the following steps: a) dissolving part of a water-soluble colloid and a filling substance in water to form an aqueous phase; b) adding a carotenoid crystal to the aqueous phase and stirring for dispersion so as to form a dispersion liquid; c) loading the dispersion liquid into a first-stage grinding machine for first grinding to form a first-stage grinding liquid; d) adding the remaining water-soluble colloid and filling substance to the first-stage grinding liquid, loading same into a second grinding machine for secondary grinding to obtain a second-stage grinding liquid; and e) drying the moisture in the second-stage grinding liquid to obtain carotenoid dry powder or particles.