Abstract: This disclosure provides cell surface anchoring conjugates, formulations comprising cell surface anchoring conjugates, STING agonist and methods of using the same for boosting immunity in a subject and treating tumor cell and cancer.

Abstract: A configurable semiconductor device (“CSD”) is organized in four (4) quadrants able to perform user-defined logic functions via a clock fabric. The first quadrant, in one embodiment, includes a first serializer and deserializer (“SerDes”) region and a bank0 region for data processing. The second quadrant includes a second SerDes region and a bank5 region and the third quadrant contains a bank3 region and a bank4 region. The fourth quadrant includes a bank1 region and a bank2 region. The clock fabric is configured to provide a set of programmable or selectable clock signals with different clock speeds to various regions within the CSD.

Abstract: A configurable semiconductor device (“CSD”) is organized in four (4) quadrants able to perform user-defined logic functions via a clock fabric. The first quadrant, in one embodiment, includes a first serializer and deserializer (“SerDes”) region and a bank0 region for data processing. The second quadrant includes a second SerDes region and a bank5 region and the third quadrant contains a bank3 region and a bank4 region. The fourth quadrant includes a bank1 region and a bank2 region. The clock fabric is configured to provide a set of programmable or selectable clock signals with different clock speeds to various regions within the CSD.

Abstract: Methods and devices with noninvasive means for providing moisture from breath to the eyes and nose, for relieving dry eye symptoms and relieving dry nose symptoms, and to hydrate the eyes, nose and facial skin are described. The device for relieving dry eye symptoms comprises a face covering over the nose, a breath deflector and a means that can attach the device to the face.

Abstract: Methods and therapeutic devices with noninvasive means for improving brain function including memory and sleep, improving eye health, improving digestive system health and improving immune functions are described. The non-invasive means is selected from electrical stimulation, heat stimulation, IR (infrared) radiation, mechanical stimulation or their combinations. In some embodiments, the method and device utilize stimulation to selected skin area on human body to achieve desired therapeutical effects.

Abstract: A configurable semiconductor device (“CSD”) is organized in four (4) quadrants able to perform user-defined logic functions via a clock fabric. The first quadrant, in one embodiment, includes a first serializer and deserializer (“SerDes”) region and a bank0 region for data processing. The second quadrant includes a second SerDes region and a bank5 region and the third quadrant contains a bank3 region and a bank4 region. The fourth quadrant includes a bank1 region and a bank2 region. The clock fabric is configured to provide a set of programmable or selectable clock signals with different clock speeds to various regions within the CSD.

Abstract: Methods and devices with noninvasive means for improving health such as treating itching especially skin itchiness are described. The non-invasive means is selected from electrical stimulation, heat or cold stimulation, IR (infrared) radiation, mechanical stimulation or their combinations. In some embodiments, the method and device utilizes electrical current passed through skin including the site having itchy feeling to achieve the desired therapeutical and beneficial effects.

Abstract: Methods and therapeutic devices with noninvasive means for improving brain function and treating senile dementia including Alzheimer’s disease are described. The noninvasive means is selected from electrical stimulation, heat stimulation, IR (infrared) radiation or their combinations. In some embodiments, the method and device utilize electrical current passed through acupuncture sites on the human head to achieve desired therapeutical effects.

Abstract: A configurable semiconductor device (“CSD”) is organized in four (4) quadrants able to perform user-defined logic functions via a clock fabric. The first quadrant, in one embodiment, includes a first serializer and deserializer (“SerDes”) region and a bank0 region for data processing. The second quadrant includes a second SerDes region and a bank5 region and the third quadrant contains a bank3 region and a bank4 region. The fourth quadrant includes a bank1 region and a bank2 region. The clock fabric is configured to provide a set of programmable or selectable clock signals with different clock speeds to various regions within the CSD.

Abstract: Compositions and methods are described for the prevention, treatment, or management of sexual dysfunction, such as premature ejaculation. The method comprises administering an effective amount of tetrahydropalmatine or its derivative or Rhizoma Corydalis extract containing composition to a human male on an as-needed basis shortly before sexual activity to delay ejaculation.

Abstract: This disclosure provides cancer cell lysing agent, formulations comprising cancer cell lysing agent, and methods of using the same for treating cancer.

Abstract: This disclosure provides cell surface anchoring antigen conjugates, formulations comprising cell surface anchoring antigen conjugates, and methods of using the same for treating cancer.

Abstract: A configurable semiconductor device (“CSD”) is organized in four (4) quadrants able to perform user-defined logic functions via a clock fabric. The first quadrant, in one embodiment, includes a first serializer and deserializer (“SerDes”) region and a bank0 region for data processing. The second quadrant includes a second SerDes region and a bank5 region and the third quadrant contains a bank3 region and a bank4 region. The fourth quadrant includes a bank 1 region and a bank2 region. The clock fabric is configured to provide a set of programmable or selectable clock signals with different clock speeds to various regions within the CSD.

Abstract: This disclosure provides cell surface anchoring conjugates that can bind with an exogenous antibody, compositions and formulations comprising said cell surface anchoring conjugates, TLR agonist and methods of using the same for boosting immunity in a subject and treating tumor cell and cancer.

Abstract: Methods and therapeutic devices with noninvasive means for improving brain function, improving eye health, improving digestive system health and improving immune functions are described. The non-invasive means is selected from electrical stimulation, heat stimulation, IR (infrared) radiation, mechanical stimulation or their combinations. In some embodiments, the method and device utilize stimulation to selected skin area on human body to achieve desired therapeutical effects.

Abstract: This disclosure provides agents, compositions and methods for treating cancer by treating tumor in a subject. The composition comprises cancer cell inactivating agent and immune activity enhancing agent in a sustained release formulation, which can be used as intratumoral injection to convert the treated tumor into an in situ vaccine for cancer. Suitable immune activity enhancing agents include TLR agonist and STING agonist.

Abstract: Methods, system and reagents to treat cancer using magnetic particle are disclosed. The method comprises giving patient magnetic particle in combination with TLR agonist type composition and optionally later followed by immune check point inhibitor treatment at therapeutical effective amount. The magnetic particle and TLR agonist type composition is given by intratumoural injection.

Abstract: Compositions, reagents, formulations and methods to treat disease including autoimmune diseases and allergy are described. The compositions comprise an antigen causing immune intolerance, an immunosuppressant in a sustained release formulation. The methods, compositions, formulations and reagents to treat allergy also relate to applying the combination of allergen and immune activity enhancing agent in a sustained release formulation to a subject in need.

Abstract: The present disclosure provides compositions for inducing immune tolerance and methods to modify antigen to treat allergy and autoimmune disease. Disclosed are compositions, and related methods, comprising APC presentable antigens and immunosuppressants that provide tolerogenic immune responses specific to antigen. In some embodiments, the composition is in a skin patch.

Abstract: A field-programmable gate array (“FPGA”) contains a configurable semiconductor organized in multiple clock regions with a clock fabric for facilitating user-defined logic functions. The clock fabric provides a set of regional clock signals (“RCSs”) generated from a clock source with a high clock signal quality (“CSQ”) for clocking logic blocks in a clock region. Also, a set of neighboring clock signals (“NCSs”) or inter-regional clock signals are generated from a neighboring clock source(s) for clocking logic blocks in two neighboring regions. In addition, the clock fabric is operable to provide secondary clock signals (“SCSs”) generated from the RCSs with a low CSQ for clocking logic blocks with less time-sensitive logic operations.