Abstract: A series of peptide-drug conjugates that react with multi-arm polyethylene glycol (PEG) to form chemically cross-linked hydrogels and their use as both a sealant and a therapeutic depot is disclosed.

Abstract: Embodiments of the present disclosure provide systems and methods for implementing self-bias detection based on performance and importance. A disclosed computer implemented method aggregates continuous input data through a K-means clustering algorithm to reduce the number of aggregated sub-group data pairs, enabling a reduced calculation time for computing bias and enhanced performance. The self-bias detection identifies a scale factor and a balance factor of aggregated sub-group data pairs, which indicate the importance of the detected bias.

Abstract: Embodiments of the present disclosure provide systems and methods for implementing self-bias detection based on performance and importance. A disclosed computer implemented method aggregates continuous input data through a K-means clustering algorithm to reduce the number of aggregated sub-group data pairs, enabling a reduced calculation time for computing bias and enhanced performance. The self-bias detection identifies a scale factor and a balance factor of aggregated sub-group data pairs, which indicate the importance of the detected bias.

Abstract: A method performed by at least one processor of a network device in communication with a plurality of base stations, the method including: receiving historical data collected by one or more base stations from the plurality of base stations, the historical data indicating one or more of a power consumption, handover data, and quality of service (QOS); generating, from the historical data, training data comprising a plurality of cell states and a corresponding random action for each cell state; and training one or more neural network estimators based on the training data, where the one or more neural network estimators comprise one or more of a power consumption estimator, a QoS estimator, and a handover prediction estimator, and where each base station from the plurality of base stations is associated with a respective cell.

Abstract: Methods and apparatus for predicting an association between input data in a first modality and data in a second modality using a statistical model trained to represent interactions between data having a plurality of modalities including the first modality and the second modality, the statistical model comprising a plurality of encoders and decoders, each of which is trained to process data for one of the plurality of modalities, and a joint-modality representation coupling the plurality of encoders and decoders. The method comprises selecting, based on the first modality and the second modality, an encoder/decoder pair or a pair of encoders, from among the plurality of encoders and decoders, and processing the input data with the joint-modality representation and the selected encoder/decoder pair or pair of encoders to predict the association between the input data and the data in the second modality.

Abstract: Rapid and data-efficient training of an artificial intelligence (AI) algorithm are disclosed. Ground truth data are not available and a policy must be learned based on limited interactions with a system. A policy bank is used to explore different policies on a target system with shallow probing. A target policy is chosen by comparing a good policy from the shallow probing with a base target policy which has evolved over other learning experiences. The target policy then interacts with the target system and a replay buffer is built up. The base target policy is then updated using gradients found with respect to the transition experience stored in the replay buffer. The base target policy is quickly learned and is robust for application to new, unseen, systems.

Abstract: A computer-implemented method, a system and a computer program product for device failure detection are disclosed. In the method, phase-based predictions may be performed on a plurality of storage devices to determine a plurality of sampling scopes and corresponding sampling ratios. The respective sampling scopes may comprise at least one storage device of the plurality of storage devices. A sampling dataset may be obtained by selecting a group of storage devices from the respective sampling scopes with the corresponding sampling ratios. Device failure may be detected for the group of storage devices based on the sampling dataset.

Abstract: The present disclosure provides methods, apparatuses, systems, and computer-readable mediums for operating a target base station by an apparatus. A method includes collecting a plurality of trajectories corresponding to the target base station and a plurality of source base stations, clustering, using an unsupervised reinforcement learning model, the plurality of trajectories into a plurality of clusters including a target cluster, selecting, as a target trajectory, a selected trajectory from the target cluster that maximizes an energy-saving parameter of the target base station, and applying, to the target base station, an energy-saving control policy corresponding to the target trajectory. The target cluster corresponds to the target base station and at least one source base station from among the plurality of source base stations.

Abstract: Transfer learning based on prediction determines a similarity between a source base station and a target base station. Importance of parameters is determined and training is adjusted to respect the importance of parameters. A lack of historical data is compensated by selecting a base station as source base station which has a larger amount of historical data.

Abstract: Provided herein are methods for inhibiting ALPK1 kinase activity using a compound of Formula I, and compositions and methods for therapy, for example in treating Kawasaki Disease.

Abstract: Provided herein are compounds of Formula (I) or (II) and related compositions and methods for their use as inhibitors of alpha-kinase 1 (ALPK1) and in treating Kawasaki Disease.

Abstract: A method is provided. The method includes receiving a first dimension set, extracting a first latent feature set from the first dimension set, training a first base predictor based on the first feature set, generating a second dimension set based on the first dimension set, the second dimension set having fewer dimensions than the first dimension set, extracting a second latent feature set from the second dimension set, training a second base predictor based on the second feature set, and generating a traffic prediction based on the first base predictor and the second base predictor.

Abstract: Methods and apparatus for predicting an association between input data in a first modality and data in a second modality using a statistical model trained to represent interactions between data having a plurality of modalities including the first modality and the second modality, the statistical model comprising a plurality of encoders and decoders, each of which is trained to process data for one of the plurality of modalities, and a joint-modality representation coupling the plurality of encoders and decoders. The method comprises selecting, based on the first modality and the second modality, an encoder/decoder pair or a pair of encoders, from among the plurality of encoders and decoders, and processing the input data with the joint-modality representation and the selected encoder/decoder pair or pair of encoders to predict the association between the input data and the data in the second modality.

Abstract: The disclosure provides compositions and methods related to activating alpha-kinase 1 (ALPK1) for modulating an immune response and treating or preventing cancer, infection, inflammation and related diseases and disorders as well as potentiating an immune response to a target antigen. The disclosure also provides heterocyclic compounds of formula (I) as agonists of alpha protein kinase 1 (ALPK1) and their use in activating ALPK1, modulating an immune response and treating diseases such as cancer, wherein A1, A2, L1, L2, L3, Z1, Z2, W1, W2, R1, R2, R3, R4, R5, R6 and R7 are defined herein.

Abstract: Provided are compounds of Formula (I) or (II) and related compositions and methods for their use as inhibitors of alpha-kinase 1 (ALPK1).

Abstract: Provided are compounds of Formula I, compositions and methods for their use as inhibitors of alpha-kinase 1 (ALPK1).

Abstract: Hybrid use of dual policies is provided to improve a communication system. In a multiple access scenario, when an inactive user equipment (UE) transitions to an active state, it may be become a burden to a radio cell on which it was previously camping. In some embodiments, hybrid load balancing is provided using a hierarchical machine learning paradigm based on reinforcement learning in which an LSTM generates a goal for one policy influencing cell reselection so that another policy influencing handover over active UEs can be assisted. The communication system as influenced by the policies is modeled as a Markov decision process (MDP). The policies controlling the active UEs and inactive UEs are coupled, and measureable system characteristics are improved. In some embodiments, policy actions depend at least in part on energy saving.

Abstract: A computer-implemented method for compressing a machine learning model includes converting an input machine learning model into a standard machine learning model. The method further includes converting the standard machine learning model into a plurality of pruned machine learning models, each of the pruned machine learning models converted using a corresponding pruning ratio from a pruning ratio candidate list. The method further includes determining, for each of the pruned machine learning models, a size-to-error ratio. The method further includes selecting, based on the size-to-error ratio of the pruned machine learning models, a first pruning ratio from the pruning ratio candidate list. The method further includes generating a compressed machine learning model by compressing the input machine learning model using the first pruning ratio that is selected. The method further includes deploying the compressed machine learning model for production.

Abstract: A method, computer program, and computer system are provided for load forecasting. Datasets corresponding to source machine learning models and a target domain base model are identified. A set of forecasting models corresponding to the identified datasets are learned. An ensemble model is determined from the learned set of forecasting models based on gradient boosting. An available resource is allocated based on the ensemble model.

Abstract: The disclosure provides compositions and methods related to activating alpha-kinase 1 (ALPK1) for modulating an immune response and treating or preventing cancer, infection, inflammation and related diseases and disorders as well as potentiating an immune response to a target antigen. The disclosure also provides heterocyclic compounds of formula (I) as agonists of alpha protein kinase 1 (ALPK1) and their use in activating ALPK1, modulating an immune response and treating diseases such as cancer, wherein A1, A2, L1, L2, L3, Z1, Z2, W1, W2, R1, R2, R3, R4, R5, R6 and R7 are defined herein.