Abstract: An electron paramagnetic resonant (EPR) instrument able to determine chemical properties of a sample using paramagnetic resonance is provided. In one embodiment, the instrument is able to measure the paramagnetic concentration of a wide variety of practical substances, ranging from food and beverages to biological specimens and solid-state electronic materials. The disclosed device can be portable and perform a measurement faster than commonly used techniques to quantify this parameter, including methods that use vibrating sample magnetometers and currently available electron paramagnetic resonance spectrometers.

Abstract: An electron paramagnetic resonant (EPR) instrument able to determine chemical properties of a sample using paramagnetic resonance is provided. In one embodiment, the instrument is able to measure the paramagnetic concentration of a wide variety of practical substances, ranging from food and beverages to biological specimens and solid-state electronic materials. The disclosed device can be portable and perform a measurement faster than commonly used techniques to quantify this parameter, including methods that use vibrating sample magnetometers and currently available electron paramagnetic resonance spectrometers.

Abstract: The invention provides a novel class of long-acting photoreceptor-binding nanoparticles, methods of their preparation, and compositions and uses thereof. The invention also relates to use of such nanoparticles and compositions for NIR light sensation and pattern vision, visual enhancement and repair, and other ophthalmology therapies.

Abstract: The present invention relates to novel compositions and methods to induce, and/of modulate bio-electrical rhythms (e.g. in cardiac, neuronal and pancreatic cells) by fine-tuning the activity of HCN-encoded pacemaker channels via a novel protein- and genetic-engineering approach to augment or attenuate the associated physiological responses (e.g. heart beat, neuronal firing, insulin secretion, etc) for achieving various therapeutic purposes (e.g. sick sinus syndrome, epilepsy, neuropathic pain, diabetes, etc).

Abstract: The present invention relates to novel compositions and methods to induce, and/of modulate bio-electrical rhythms (e.g. in cardiac, neuronal and pancreatic cells) by fine-tuning the activity of HCN-encoded pacemaker channels via a novel protein- and genetic-engineering approach to augment or attenuate the associated physiological responses (e.g. heart beat, neuronal firing, insulin secretion, etc) for achieving various therapeutic purposes (e.g. sick sinus syndrome, epilepsy, neuropathic pain, diabetes, etc).

Abstract: The present invention relates to novel compositions and methods to induce, and/or modulate bio-electrical rhythms (e.g. in cardiac, neuronal and pancreatic cells) by fine-tuning the activity of HCN-encoded pacemaker channels via a novel protein- and genetic-engineering approach to augment or attenuate the associated physiological responses (e.g. heart beat, neuronal firing, insulin secretion, etc) for achieving various therapeutic purposes (e.g. sick sinus syndrome, epilepsy, neuropathic pain, diabetes, etc).

Abstract: Self-renewable embryonic stem cells (ESCs), derived from the inner cell mass of blastocysts, can propagate indefinitely in culture while maintaining their normal karyotypes and pluripotency to differentiate into all cell types. Therefore, ESCs may provide an unlimited supply of even specialized cells such as brain and heart cells for transplantation and cell-based therapies that are otherwise limited by donor availability. However, this promising application is hampered by concerns that ESCs or their multipotent derivatives also possess the potential to form malignant tumors after transplantation in vivo. The present invention provides for a novel genetic method to arrest undesirable cell division (of ESCs and other unwanted lineages) as a means to inhibit or eliminate their tumorgenic potential after transplantation.

Abstract: The present invention relates to novel compositions and methods to induce, and/or modulate bio-electrical rhythms (e.g. in cardiac, neuronal and pancreatic cells) by fine-tuning the activity of HCN-encoded pacemaker channels via a novel protein- and genetic-engineering approach to augment or attenuate the associated physiological responses (e.g. heart beat, neuronal firing, insulin secretion, etc) for achieving various therapeutic purposes (e.g. sick sinus syndrome, epilepsy, neuropathic pain, diabetes, etc).