Abstract: The disclosure relates to the field of medicinal chemistry. Disclosed are a 14-chloro-?-elemene nitric oxide donor derivative and a preparation method and use thereof in the preparation of anti-tumor drugs. The 14-chloro-?-elemene nitric oxide donor derivative has a general formula shown in formula (I): in formula (I): R1 represents a linear or cyclic alcohol amine structure containing nitrogen and oxygen atoms; and each of R2 and R3 is independently selected from the group consisting of C1-10 alkyl, C3-12 cycloalkyl, C6-12 aryl, 5- to 10-membered cyclic heteroaryl, C2-10 alkenyl, C2-10 alkynyl, and C2-10 alkoxy.

Abstract: This application provides a secure boot apparatus and method. A control circuit in the secure boot apparatus can obtain boot code in a nonvolatile memory by using a non-programmable circuit, and verify the boot code by using a root of trust. In this way, even if the root of trust is not built in a processor, the verification on the boot code can be implemented by using the control circuit. This effectively reduces dependency of a secure boot process on processor performance. In addition, because the non-programmable circuit can be respectively coupled to the control circuit and the nonvolatile memory through two interfaces of different types, a requirement for the secure boot process on an interface protocol type of the control circuit is reduced, and application flexibility of a secure boot solution is improved.

Abstract: A quantum layout optimization method includes: determining target Hamiltonian parameters of a quantum device; determining an initial quantum layout of the quantum device and initial geometric parameters of the initial quantum layout; determining a target gradient of Hamiltonian parameters of the quantum device to geometric parameters of the initial quantum layout; and adjusting the initial geometric parameters based on the target gradient to have the Hamiltonian parameters of the quantum device be the target Hamiltonian parameters to obtain a target quantum layout.

Abstract: A computational instance may contain queues configured to hold work items. The work items may be representations of user submissions requesting actions from a plurality of agents. The computational instance may also contain computing devices configured to: (a) obtain a set of assignment rules that specify mappings between (i) respective selection criteria for the assignment rules, and (ii) one or more candidate agents from the plurality of agents that can be assigned to address the work items with content that match the respective selection criteria, (b) read, from the queues, a work item corresponding to a user submission, (c) iterate through the assignment rules according to an ordering until a particular assignment rule with associated selection criteria that matches content of the work item is found, and (d) assign the work item to a particular agent from the one or more candidate agents.

Abstract: Disclosed by the present invention is a method for preparing a reactive sealant resin, the method comprising: (1) under the action of an alkali catalyst, polymerizing a hydroxyl-containing initiator with an epoxy compound to obtain a polyether polyol; (2) adding an alkoxide reagent and a halogenated end-capping agent containing a double bond to the polyether polyol obtained in step (1) for reaction, so as to obtain a crude double-bonded polyether product, and refining the crude product to obtain a modified polyether product; and (3) subjecting the modified polyether and hydrogen-containing silane to silane end-capping reaction under the action of a hydrosilylation catalyst, so as to obtain the target product, i.e., a reactive sealant resin. The resin has excellent properties as well as good adhesion and paintability.

Abstract: Skill determination rules may be defined and applied to work items to identify the relevant skills associated with the work item. A skill determination rule definition graphical user interface (GUI) may be utilized to received date defining one or more skill determination rules. Once skill determination rules are defined, upon receipt of a work item, the relevant skill determination rules may be identified and applied to identify relevant skills associated with the work item. An agent possessing the identified skills may be identified and the work item added to the selected agent's queue.

Abstract: A computational instance may contain queues configured to hold work items. The work items may be representations of user submissions requesting actions from a plurality of agents. The computational instance may also contain computing devices configured to: (a) obtain a set of assignment rules that specify mappings between (i) respective selection criteria for the assignment rules, and (ii) one or more candidate agents from the plurality of agents that can be assigned to address the work items with content that match the respective selection criteria, (b) read, from the queues, a work item corresponding to a user submission, (c) iterate through the assignment rules according to an ordering until a particular assignment rule with associated selection criteria that matches content of the work item is found, and (d) assign the work item to a particular agent from the one or more candidate agents.

Abstract: The invention is directed to the enhanced expression and purification of lipoxygenase enzymes. These enzymes are of wide-spread industrial importance, often produced in heterologous microbial systems. Preferably, the lipoxygenase produced by the methods of the invention is a plant-derived enzyme and expressed at high-levels in a microbial system that includes a protease-deficient host and one or more chaperone expression plasmids. The invention is also directed to amino acid and nucleic acid fragments of the lipoxygenase enzyme including fragments in expression constructs encoding all or a portion of one or more lipoxygenase genes. The invention is also directed to methods of manufacturing bread and other food and also non-food products with lipoxygenase manufactured by the methods of the invention.

Abstract: The invention is directed to the enhanced expression and purification of lipoxygenase enzymes. These enzymes are of wide-spread industrial importance, often produced in heterologous microbial systems. Preferably, the lipoxygenase produced by the methods of the invention is a plant-derived enzyme and expressed at high-levels in a microbial system that includes a protease-deficient host and one or more chaperone expression plasmids. The invention is also directed to amino acid and nucleic acid fragments of the lipoxygenase enzyme including fragments in expression constructs encoding all or a portion of one or more lipoxygenase genes. The invention is also directed to methods of manufacturing bread and other food and also non-food products with lipoxygenase manufactured by the methods of the invention.

Abstract: Embodiments of the present invention disclose a method and apparatus for participating in sensing data collection. The method comprises: for each of multiple user equipments, calculating probabilities that the user equipment is located in respective subareas of a predetermined area at a predetermined time by using historical movement information of the user equipment; determining types of sensing data to be collected when the user equipment is located in the respective subareas, based on capability information of the user equipment for collecting sensing data; and obtaining a utility value of the user equipment associated with sensing data collection within the predetermined area, based on the probabilities calculated for the respective subareas and the determined types of sensing data. The method further comprises selecting one or more user equipments from the multiple user equipments for collection of participatory sensing data, based on multiple utility values obtained for the multiple user equipments.

Abstract: The invention is directed to the enhanced expression and purification of lipoxygenase enzymes. These enzymes are of wide-spread industrial importance, often produced in heterologous microbial systems. Preferably, the lipoxygenase produced by the methods of the invention is a plant-derived enzyme and expressed at high-levels in a microbial system that includes a protease-deficient host and one or more chaperone expression plasmids. The invention is also directed to amino acid and nucleic acid fragments of the lipoxygenase enzyme including fragments in expression constructs encoding all or a portion of one or more lipoxygenase genes. The invention is also directed to methods of manufacturing bread and other food and also non-food products with lipoxygenase manufactured by the methods of the invention.

Abstract: A fuel injection system for a fuel system of a compression-ignition engine is disclosed. In the current disclosure, the fuel injection system includes a common rail, at least one control valve, and a controller. The common rail may be configured to receive fuel from a fuel pump of the fuel system. The at least one control valve may be in fluid communication with the common rail and at least one fuel nozzle of the fuel system. The at least one control valve may be configured to receive fuel from the common rail. Further, the at least one control valve may be configured to supply fuel to the at least one fuel nozzle. The controller may be configured to control the at least one control valve.