Patents by Inventor Tianao Yuan

Tianao Yuan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FUSION PROTEINS COMPRISING ACID ALPHA-GLUCOSIDASE ENZYMES AND METHODS THEREOF
    Publication number: 20250250555
    Abstract: Provided herein are proteins, which are capable of being transported across the blood-brain barrier (BBB) and comprise an acid alpha-glucosidase (GAA) enzyme-Fc fusion polypeptide. Certain embodiments also provide methods of using such proteins to treat Pompe disease.
    Type: Application
    Filed: March 17, 2025
    Publication date: August 7, 2025
    Applicant: DENALI THERAPEUTICS INC.
    Inventors: Mihalis S. KARIOLIS, Melina LENSER, Cathal S. MAHON, Hanh Giai NGO, Yashas RAJENDRA, Shrishti TYAGI, Tianao YUAN
  • Fusion proteins comprising acid alpha-glucosidase enzymes and methods thereof
    Patent number: 12378540
    Abstract: Provided herein are proteins, which are capable of being transported across the blood-brain barrier (BBB) and comprise an acid alpha-glucosidase (GAA) enzyme-Fc fusion polypeptide. Certain embodiments also provide methods of using such proteins to treat Pompe disease.
    Type: Grant
    Filed: March 17, 2025
    Date of Patent: August 5, 2025
    Assignee: DENALI THERAPEUTICS INC.
    Inventors: Mihalis S. Kariolis, Melina Lenser, Cathal S. Mahon, Hanh Giai Ngo, Yashas Rajendra, Shrishti Tyagi, Tianao Yuan
  • Azasteroids for treatment of tuberculosis
    Patent number: 11072633
    Abstract: The present invention provides a compound having the structure: for use in combination with an anti-tuberculosis drug for treating a subject infected with M. tuberculosis.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: July 27, 2021
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Nicole Sampson, Xinxin Yang, Tianao Yuan
  • AZASTEROIDS FOR TREATMENT OF TUBERCULOSIS
    Publication number: 20190161514
    Abstract: The present invention provides a compound having the structure: for use in combination with an anti-tuberculosis drug for treating a subject infected with M. tuberculosis.
    Type: Application
    Filed: April 28, 2017
    Publication date: May 30, 2019
    Applicant: The Research Foundation for the State University of New York
    Inventors: Nicole Sampson, Xinxin Yang, Tianao Yuan