Publication number: 20050209225
Abstract: The present invention relates to novel substituted indole compounds that are antagonists of alpha V (?v) integrins, for example ?v?3 and ?v?5 integrins, their pharmaceutically acceptable salts, and pharmaceutical compositions thereof. The compounds may be used in the treatment of pathological conditions mediated by ?v?3 and ?v?5 integrins, including such conditions as tumor growth, metastasis, restenosis, osteoporosis, inflammation, macular degeneration, diabetic retinopathy, and rheumatoid arthritis. The compounds have the general formula: where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, D, X, W, a, m, n, i, j, k and v are defined herein.
Type:
Application
Filed:
December 6, 2004
Publication date:
September 22, 2005
Inventors:
Tianbao Lu, Louis LaFrance, Bruce Tomczuk, Thomas Markotan, Juan Marugan Sanchez, Victor Marder, David U'Prichard, Beth Anaclerio, Zihong Guo, Wenzi Pan, Kristi Leonard