Abstract: A method, device, equipment for user grouping, and a non-transitory computer-readable storage medium are provided, which are applicable to the field of medical technology. The method includes the following. Net benefits of multiple users in a target project are obtained. According to the net benefits of the multiple users in the target project and a solution of the target project, a net-benefit coefficient corresponding to the solution is determined. For each grouping variable of the target project, a fluctuation value corresponding to the grouping variable is determined according to the net-benefit coefficient. According to a grouping variable with the largest fluctuation value, the multiple users are divided into multiple user groups. For each user group obtained by division, users in the user group are divided according to a fluctuation value corresponding to each grouping variable of the target project, until a user group meeting a preset condition is obtained.