Patents by Inventor TIANJIAN LI
TIANJIAN LI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240125969Abstract: The present disclosure provides a method for experimentally determining a critical sand-carrying gas velocity of a shale gas well. The method includes: collecting well structure and production data, calculating parameter ranges of a gas flow velocity and a liquid flow velocity; carrying out a physical simulation experiment of sand carrying in the shale gas well to obtain the sand holding capacity of the wellbore under different experimental conditions, and calculating a sand holding rate; by observing a change curve of the sand holding rate of the wellbore vs. the gas flow velocity, defining a turning point, and sensitively analyzing the influence of other experimental variables on the turning point, to calculate the critical sand-carrying production of the shale gas well under different conditions. Therefore, this calculation method is simple and applicable, and provides a theoretical basis for the optimization design of water drainage and gas production process.Type: ApplicationFiled: December 18, 2023Publication date: April 18, 2024Applicant: Southwest Petroleum UniversityInventors: Yonghui Liu, Jinhong Jiang, Chengcheng Luo, Ning Wu, Xuanzhi Zheng, Xinke Tang, Xin Li, Zhengyang Liu, Boren Yang, Tianjian Liu
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Patent number: 11806365Abstract: Provided herein are cells, e.g., T cells expressing artificial cell death polypeptides that cause death of a cell, e.g., cells (e.g., T lymphocytes) expressing the cell death polypeptide, when the cell death polypeptide is multimerized or dimerized. Also provided herein is use of such cells, e.g., T lymphocytes, to treat diseases such as cancer.Type: GrantFiled: March 5, 2021Date of Patent: November 7, 2023Assignee: CELGENE CORPORATIONInventors: Stewart Abbot, Tianjian Li, Bitao Liang
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Publication number: 20220348875Abstract: Provided herein are genetically modified (GM) natural killer (NK) cells and methods of producing populations of GM NK cells. Further provided herein are methods of using the GM NK cells described herein, to, e.g., suppress the proliferation of tumor cells, or to inhibit pathogen infection, e.g., viral infection. In certain alternatives, GM NK cells provided herein lack expression of CBLB, NKG2A and/or TGFBR2 and/or function or show reduced expression and/or function of CBLB, NKG2A and/or TGFBR2. In certain alternatives, GM NK cells provided herein comprise modified CD16.Type: ApplicationFiled: December 17, 2021Publication date: November 3, 2022Applicant: Celularity Inc.Inventors: Xiaokui Zhang, Qian Ye, Tianjian Li, Chuan Wang, Mini Bharathan, Uri Herzberg, Robert J. HARIRI
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Publication number: 20220118014Abstract: The present invention discloses populations of T cells expressing a chimeric antigen receptor (CAR), wherein said T cells are placental T cells derived from cord blood, placental perfusate, or a mixture thereof. Such populations of cells are shown to be improved in a number of aspects over alternative populations of cells such as those derived from peripheral blood mononuclear cell T cells. It also discloses methods of treating cancer, such as a hematologic cancer, e.g., a B cell cancer, or a symptom thereof in a patient in need thereof. These methods comprise administering to the patient an amount of the population of T cells of any one of the invention effective to alleviate the cancer or symptom thereof in the patient.Type: ApplicationFiled: December 2, 2019Publication date: April 21, 2022Applicant: Celularity Inc.Inventors: Robert J. HARIRI, Kathy KARASIEWICZ-MENDEZ, Tianjian LI
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Publication number: 20220106404Abstract: Provided herein are therapeutic polypeptides, e.g., chimeric antigen receptors, able to direct an immune cell, e.g., a T lymphocyte to a target antigen, and able to cause the T cell to proliferate or to kill cells displaying the antigen when the antigen binds to the polypeptide, wherein the polypeptides comprise a transmembrane domain from a T cell co-inhibitory protein such as CTLA4 or PD-1. Also provided herein are T lymphocytes expressing the polypeptides, and use of such T lymphocytes to treat diseases such as cancer.Type: ApplicationFiled: September 10, 2021Publication date: April 7, 2022Inventors: Stewart ABBOT, Bitao LIANG, Tianjian LI
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Publication number: 20210299175Abstract: Provided herein are cells, e.g., T cells expressing artificial cell death polypeptides that cause death of a cell, e.g., cells (e.g., T lymphocytes) expressing the cell death polypeptide, when the cell death polypeptide is multimerized or dimerized. Also provided herein is use of such cells, e.g., T lymphocytes, to treat diseases such as cancer.Type: ApplicationFiled: March 5, 2021Publication date: September 30, 2021Applicant: CELGENE CORPORATIONInventors: Stewart Abbot, Tianjian Li, Bitao Liang
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Patent number: 11130820Abstract: Provided herein are therapeutic polypeptides, e.g., chimeric antigen receptors, able to direct an immune cell, e.g., a T lymphocyte to a target antigen, and able to cause the T cell to proliferate or to kill cells displaying the antigen when the antigen binds to the polypeptide, wherein the polypeptides comprise a transmembrane domain from a T cell co-inhibitory protein such as CTLA4 or PD-1. Also provided herein are T lymphocytes expressing the polypeptides, and use of such T lymphocytes to treat diseases such as cancer.Type: GrantFiled: October 30, 2018Date of Patent: September 28, 2021Assignee: CELGENE CORPORATIONInventors: Stewart Abbot, Bitao Liang, Tianjian Li
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Publication number: 20210254003Abstract: In one embodiment, provided herein are cells, e.g., T cells expressing receptors that that cause a cell expressing the receptors to home to specific anatomical regions, e.g., the B cell zone of lymph nodes, the gastrointestinal tract, or the skin. Also provided herein is use of such cells, e.g., T lymphocytes, to treat diseases such as cancer.Type: ApplicationFiled: September 30, 2020Publication date: August 19, 2021Applicant: CELGENE CORPORATIONInventors: Bitao LIANG, Wei LIU, Tianjian LI
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Patent number: 10967005Abstract: Provided herein are cells, e.g., T cells expressing artificial cell death polypeptides that cause death of a cell, e.g., cells (e.g., T lymphocytes) expressing the cell death polypeptide, when the cell death polypeptide is multimerized or dimerized. Also provided herein is use of such cells, e.g., T lymphocytes, to treat diseases such as cancer.Type: GrantFiled: February 14, 2019Date of Patent: April 6, 2021Assignee: CELGENE CORPORATIONInventors: Stewart Abbot, Tianjian Li, Bitao Liang
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Publication number: 20190175652Abstract: Provided herein are cells, e.g., T cells expressing artificial cell death polypeptides that cause death of a cell, e.g., cells (e.g., T lymphocytes) expressing the cell death polypeptide, when the cell death polypeptide is multimerized or dimerized. Also provided herein is use of such cells, e.g., T lymphocytes, to treat diseases such as cancer.Type: ApplicationFiled: February 14, 2019Publication date: June 13, 2019Applicant: CELGENE CORPORATIONInventors: Stewart Abbot, Tianjian Li, Bitao Liang
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Publication number: 20190119399Abstract: Provided herein are therapeutic polypeptides, e.g., chimeric antigen receptors, able to direct an immune cell, e.g., a T lymphocyte to a target antigen, and able to cause the T cell to proliferate or to kill cells displaying the antigen when the antigen binds to the polypeptide, wherein the polypeptides comprise a transmembrane domain from a T cell co-inhibitory protein such as CTLA4 or PD-1. Also provided herein are T lymphocytes expressing the polypeptides, and use of such T lymphocytes to treat diseases such as cancer.Type: ApplicationFiled: October 30, 2018Publication date: April 25, 2019Applicant: CELGENE CORPORATIONInventors: Stewart Abbot, Bitao Liang, Tianjian Li
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Patent number: 10238690Abstract: Provided herein are cells, e.g., T cells expressing artificial cell death polypeptides that cause death of a cell, e.g., cells (e.g., T lymphocytes) expressing the cell death polypeptide, when the cell death polypeptide is multimerized or dimerized. Also provided herein is use of such cells, e.g., T lymphocytes, to treat diseases such as cancer.Type: GrantFiled: March 14, 2014Date of Patent: March 26, 2019Assignee: CELGENE CORPORATIONInventors: Stewart Abbot, Tianjian Li, Bitao Liang
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Patent number: 10150816Abstract: Provided herein are therapeutic polypeptides, e.g., chimeric antigen receptors, able to direct an immune cell, e.g., a T lymphocyte to a target antigen, and able to cause the T cell to proliferate or to kill cells displaying the antigen when the antigen binds to the polypeptide, wherein the polypeptides comprise a transmembrane domain from a T cell co-inhibitory protein such as CTLA4 or PD-1. Also provided herein are T lymphocytes expressing the polypeptides, and use of such T lymphocytes to treat diseases such as cancer.Type: GrantFiled: December 19, 2013Date of Patent: December 11, 2018Assignee: CELGENE CORPORATIONInventors: Stewart Abbot, Bitao Liang, Tianjian Li
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Publication number: 20180273903Abstract: Provided herein are genetically modified (GM) natural killer (NK) cells and methods of producing populations of GM NK cells. Further provided herein are methods of using the GM NK cells described herein, to, e.g., suppress the proliferation of tumor cells, or to inhibit pathogen infection, e.g., viral infection. In certain alternatives, GM NK cells provided herein lack expression of CBLB, NKG2A and/or TGFBR2 and/or function or show reduced expression and/or function of CBLB, NKG2A and/or TGFBR2. In certain alternatives, GM NK cells provided herein comprise modified CD16.Type: ApplicationFiled: December 28, 2017Publication date: September 27, 2018Applicant: Celularity, Inc.Inventors: Xiaokui Zhang, Qian Ye, Tianjian Li, Chuan Wang, Mini Bharathan, Uri Herzberg
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Publication number: 20180080008Abstract: In one embodiment, provided herein are cells, e.g., T cells expressing receptors that that cause a cell expressing the receptors to home to specific anatomical regions, e.g., the B cell zone of lymph nodes, the gastrointestinal tract, or the skin. Also provided herein is use of such cells, e.g., T lymphocytes, to treat diseases such as cancer.Type: ApplicationFiled: August 11, 2015Publication date: March 22, 2018Applicant: Anthrogenesis CorporationInventors: Bitao LIANG, Wei LIU, Tianjian LI
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Publication number: 20160030479Abstract: Provided herein are cells, e.g., T cells expressing artificial cell death polypeptides that cause death of a cell, e.g., cells (e.g., T lymphocytes) expressing the cell death polypeptide, when the cell death polypeptide is multimerized or dimerized. Also provided herein is use of such cells, e.g., T lymphocytes, to treat diseases such as cancer.Type: ApplicationFiled: March 14, 2014Publication date: February 4, 2016Applicant: ANTHROGENESIS CORPORATIONInventors: Stewart Abbot, Tianjian Li, Bitao Liang
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Publication number: 20150307623Abstract: Provided herein are therapeutic polypeptides, e.g., chimeric antigen receptors, able to direct an immune cell, e.g., a T lymphocyte to a target antigen, and able to cause the T cell to proliferate or to kill cells displaying the antigen when the antigen binds to the polypeptide, wherein the polypeptides comprise a transmembrane domain from a T cell co-inhibitory protein such as CTLA4 or PD-1. Also provided herein are T lymphocytes expressing the polypeptides, and use of such T lymphocytes to treat diseases such as cancer.Type: ApplicationFiled: December 19, 2013Publication date: October 29, 2015Applicant: ANTHROGENESIS CORPORATIONInventors: Stewart Abbot, Bitao Liang, Tianjian Li
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Patent number: 9121072Abstract: Disclosed herein are methods and compositions for rapidly identifying active nucleases and cells having nuclease-mediated genomic modifications.Type: GrantFiled: September 15, 2011Date of Patent: September 1, 2015Assignee: Sangamo BioSciences, Inc.Inventors: Michael C. Holmes, Yannick Doyon, Tianjian Li
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Patent number: 9115409Abstract: Disclosed herein are methods and compositions for rapidly identifying active nucleases and cells having nuclease-mediated genomic modifications.Type: GrantFiled: March 11, 2013Date of Patent: August 25, 2015Assignee: Sangamo BioSciences, Inc.Inventors: Yannick Doyon, Michael C. Holmes, Tianjian Li
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Publication number: 20120237926Abstract: Disclosed herein are methods and compositions for rapidly identifying active nucleases and cells having nuclease-mediated genomic modifications.Type: ApplicationFiled: September 15, 2011Publication date: September 20, 2012Inventors: Michael C. Holmes, Yannick Doyon, Tianjian Li