Abstract: This application discloses the hand sanitizer device which includes at least outlet tube and foaming sub-assembly. Said outlet tube's end connects with said foaming sub-assembly via the water tube fitting, allowing gas-liquid mixture to transmit through said outlet tube, said water tube fitting and to said foaming sub-assembly. Said foaming sub-assembly includes shell and foaming part, wherein said shell has the through hole and internal threads at one end. Said shell with internal threads connects with said water tube fitting with external threads at the end. The other end of said shell has the contact part extending internally from the other end's edge of said through hole, within which said foaming part is located and pressed between said contact part and the end of said water tube fitting. Technical proposals from this application can facilitate the changing, maintaining and cleaning the foaming part of the hand sanitizer device for users.