Abstract: The disclosure provides a two-stage molded pet toy, which consists of a hard plastic liner which is primarily molded and a flexible material mantle which is secondarily molded and sleeves the liner, wherein the liner is a hollow shell formed by mutually butting half shells of upper and lower parts, openings are formed in its two opposite ends, multiple ribs are arranged perpendicular to a length direction of the liner in the liner, nicks are formed in all of the ribs, openings are also formed in two ends of the mantle respectively, and the openings in the two ends of the mantle correspond to the openings in the two ends of the liner respectively. The pet toy is multifunctional, and has both teething and food leakage functions; and in addition, the pet toy has advantages of the hard and flexible materials, and is multifunctional.

Abstract: The disclosure provides a bowl with a freely adjustable height, comprising: a pedestal; a lifting support rod, whose one end is fixed on the pedestal; a bowl seat, which is fixed on the other end of the lifting support rod; a lifting locking piece, which has a fixing piece and an extrusion piece matched with each other, wherein the fixing piece has a fixing hole, the lifting support rod penetrates through the fixing hole and is partially located in the fixing hole, the extrusion piece exerts an action force to the fixing piece so as to fix the lifting support rod on the bowl seat, and the fixing piece is matched with and fixed on the bowl seat or arranged on the bowl seat; and a bowl body, which is arranged on the bowl seat. According to the disclosure, the height of the bowl may be adjusted freely.

Abstract: Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.

Abstract: Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.

Abstract: Provided herein are compounds of Formula (I): and forms thereof, including compositions thereof and uses therewith for treating spinal muscular atrophy.

Abstract: The disclosure relates to an outdoor pet drinking apparatus. The outdoor pet drinking apparatus comprises a bottle cap and a drinking bowl. A water outlet is provided at a top end of the bottle cap. The drinking bowl is fixed to the bottle cap. The drinking bowl is made of an elastic material. The drinking bowl is further provided with a cover or a bottle plug, which is connected to the drinking bowl and configured to cover the water outlet of the bottle cap. The drinking apparatus in the disclosure is convenient to carry outdoors so as to water or feed a pet, and the apparatus is simple to use, sanitary, and high in practicality.

Abstract: The present invention discloses a multifunctional intelligent feeding control device, comprising: a base and a feeding control dish, the feeding control dish being detachably mounted on the base, an edge of the base fastened with the feeding control dish being a flange; a accommodating space is formed between the feeding control dish and the base which are well mounted; at least one through hole is formed on the feeding control dish; and a connecting member with a ventilation function is provided above and also connected to the feeding control dish. The multifunctional intelligent feeding control device of the present invention has low manufacturing cost, smaller packaging volume due to a dismountable and mountable design, convenience for storage and reduced cost of transportation.

Abstract: The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens.

Abstract: A portable dual-use water bottle, includes an upper cap, a bottle body, and a lower bottom. The bottle body has a lower portion and a lower bottom. The lower bottom cap has a volume, the lower bottom cap being soft, and firmly buckled to the lower portion of the bottle body by the lower bottom of the bottle body and firmly sleeved and fixed thereto.

Abstract: Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.

Abstract: Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.

Abstract: Provided herein are compounds of Formula (I): and forms thereof, including compositions thereof and uses therewith for treating spinal muscular atrophy.

Abstract: The disclosure provides a foldable portable excrement pick-up device. The device includes an upper housing and a lower housing which are combined to form a clip shape via a rotary shaft and a spring. The upper housing is composed of an upper handle and a cap-shaped upper housing body. The lower housing is composed of a lower handle and a bowl-shaped lower housing body. The upper handle and the lower handle are symmetrically arranged, the upper housing body and the lower housing body are hinged to form a clip shape in such a way that the rotary shaft penetrates through the upper hinging portion and the lower hinging portion, and the spring is arranged between the upper handle and the lower handle to make the upper housing body cover the lower housing body elastically in an openable/closeable manner.

Abstract: The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of snaking nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.

Abstract: The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens.

Abstract: The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.

Abstract: Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.