Patents by Inventor Tianlin GUO

Tianlin GUO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of preventing or treating atherosclerosis with inhibitors of specific isoenzymes of human neuraminidase
    Patent number: 11773129
    Abstract: The present invention provides a method of preventing or treating atherosclerosis or a symptom thereof comprising administering to a subject in need thereof a specific inhibitor of neuraminidase 1 (neu1); neuraminidase 3 (neu3); or a bispecific inhibitor of neu1 or neu3 of formula I; (I) and a compound of formula I.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: October 3, 2023
    Assignees: The Governors of the University of Alberta, Valorisation HSJ, Limited Partnership
    Inventors: Christopher Cairo, Alexey Pchejetski, Tianlin Guo
  • PYRIDOPYRIMIDINONE DERIVATIVES AS AHR ANTAGONISTS
    Publication number: 20230295152
    Abstract: The present disclosure relates to compounds of formula (Ia) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same, methods of preparing the same, intermediate compounds useful for preparing the same, and methods for treating or prophylaxis of diseases, in particular cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling. These compounds may also be useful in treating cancer when administered in combination with at least one additional therapy.
    Type: Application
    Filed: November 20, 2020
    Publication date: September 21, 2023
    Applicant: SENDA BIOSCIENCES, INC.
    Inventors: Alessandra BARTOLOZZI, John Robert PROUDFOOT, Timothy BRIGGS, John MANCUSO, Karunakar Reddy BONEPALLY, Patrick BUREAU, Tianlin GUO, Maxence BOS, Anna BLOIS, Bernard LANTER, Steven John TAYLOR, Leonard BUCKBINDER, Francesca BARONE
  • Fused Azole Heterocycles as AHR Antagonists
    Publication number: 20230234967
    Abstract: The present disclosure relates to thiazolo-pyridine, oxazolo-pyridine, pyrrolo-pyridine, pyrrolo-pyrazine and pyrrolo-pyrimidine compounds and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same, methods of preparing the same, intermediate compounds useful for preparing the same, and methods for treating or prophylaxis of diseases, in particular cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling.
    Type: Application
    Filed: May 27, 2021
    Publication date: July 27, 2023
    Inventors: Alessandra Bartolozzi, John Robert Proudfoot, Timothy Briggs, John Mancuso, Maxence Bos, Tianlin Guo, Vu Linh Ly, Anna Blois, Bernard Lanter, Steven John Taylor, Leonard Buckbinder
  • METHODS OF MODULATING LEUKOCYTES ACTIVATION AND THROMBOCYTE CLEARANCE WITH INHIBITORS OF SPECIFIC NEURAMINIDASE ISOENZYMES
    Publication number: 20220110919
    Abstract: The present invention provides a method of modulating leukocytes activation (e.g., adhesion and/or transmigration and/or cytokine response) and a method of modulating thrombocyte clearance comprising administering to a subject in need thereof a specific inhibitor of neuraminidase 1 (neu1); neuraminidase 3 (neu3) or neuraminidase 4 (neu4); or a bispecific inhibitor of neu1, neu3 or neu4 of formula (I): (I) Also provided are pharmaceutical compositions comprising the inhibitor compound of formula (1), and uses thereof for modulating leukocytes activation or modulating thrombocyte clearance.
    Type: Application
    Filed: November 29, 2019
    Publication date: April 14, 2022
    Inventors: Alexey Pchejetski, Christopher Cairo, Tianlin Guo, Md. Amran Howlader, Ekterina Demina
  • METHODS OF PREVENTING OR TREATING ATHEROSCLEROSIS WITH INHIBITORS OF SPECIFIC ISOENZYMES OF HUMAN NEURAMINIDASE
    Publication number: 20200239512
    Abstract: The present invention provides a method of preventing or treating atherosclerosis or a symptom thereof comprising administering to a subject in need thereof a specific inhibitor of neuraminidase 1 (neu1); neuraminidase 3 (neu3); or a bispecific inhibitor of neu1 or neu3 of formula I; (I) and a compound of formula I.
    Type: Application
    Filed: May 25, 2018
    Publication date: July 30, 2020
    Inventors: Christopher CAIRO, Alexey PCHEJETSKI, Tianlin GUO