Abstract: Disclosed are a carbocyclic nucleoside, an oligonucleotide and preparation methods therefor and medical uses thereof, and the carbocyclic nucleoside is a compound or salt shown in the following Formula (I). The oligonucleotide or pharmaceutically acceptable salt thereof provided in the present disclosure can be used for preparing a drug for gene therapy, gene vaccination, antisense therapy, short interfering RNA, or nucleic acid transfer. The oligonucleotide in the present disclosure has high binding affinity to single-stranded RNA, increase stability to nuclease degradation and plasma stability.

Abstract: A method and a system for manufacturing a structure includes the steps of: (a) supplying a mixture consisting a plurality of primitive materials at a target spot; (b) melting and solidifying the mixture disposed at the target spot to form a portion of a metallic structure consisting of an alloy of the plurality of the primitive materials; and (c) repeating steps (a) and (b) at a plurality of target spots in a three-dimensional space to produce the metallic structure of the alloy.

Abstract: A method and a system for manufacturing a structure includes the steps of: (a) supplying a mixture consisting a plurality of primitive materials at a target spot; (b) melting and solidifying the mixture disposed at the target spot to form a portion of a metallic structure consisting of an alloy of the plurality of the primitive materials; and (c) repeating steps (a) and (b) at a plurality of target spots in a three-dimensional space to produce the metallic structure of the alloy.