Abstract: A microwave or other radio frequency (RF) hyperthermia system and method with improved uniformity and selection of heating. The novel apparatus has a single applicator or an array of applicators excited by the RF/microwave sources and connecting with some kind of controlling and monitoring subsystems. It is used for ether hyperthermia or acupuncture to provide invasive and noninvasive medical treatment to the target inside a human body. The individual applicator consists of a central signal coaxial needle surrounded by a plurality of secondary needles to enclose the heated target. The applicator guides the wave to move forwardly further resulting in a penetration improvement, and also to reduce the backward reflection from the radiator end, thus to make the boundary of heating pattern clear-defined. Such a guided-wave acupuncture needles or like-needles array producing a quasi-TEM electromagnetic (EM) radiation makes even one individual radiation applicator have a capability of EM energy focus.