Abstract: The subject invention pertains to compositions and methods for inhibiting IGF2 signaling. Insulin-like growth factor 2 (IGF2) is a key signaling molecule that plays important roles in various physiological processes, including skeletal myogenesis during development and adult muscle remodeling. Abnormal activation of the signaling pathway induced by IGF2 has been shown to promote cancer progression. TMED10, a p24 family protein, functions as a cargo receptor, promoting the export of IGF2 from the endoplasmic reticulum (ER) via recognizing an ER export signal on IGF2. Moreover, TMED10 also mediates ER export of sortilin, which is important to regulate the export of IGF2 from the trans-Golgi network. The subject invention features a novel therapeutic strategy for cancer treatment, that includes, but is not limited to, inhibitors targeting the interaction between IGF2 and TMED10.

Abstract: The present disclosure provides Emission Computed Tomography (ECT) detector assemblies and related methods. The ECT detector assemblies may include a detector micro-block, a detector block, etc. The detector micro-block may include detector units arranged side by side along a second direction. Each of the detector units may include crystal elements and an optical sensor array. The crystal elements may be arranged in crystal element rows along the second direction and crystal element columns along a first direction perpendicular to the second direction. Each crystal element may have a first end and a second end and extending from the first end to the second end along a third direction perpendicular to the first direction and the second direction. The optical sensor array may include optical sensors arranged along the first direction.

Abstract: A display panel, a display module and a display device. The display panel includes: a substrate in a stacked arrangement, a light-emitting device layer, a light extraction layer assembly, and a barrier layer; wherein the light extraction layer assembly includes at least two light extraction layers in a stacked arrangement, the at least two light extraction layers including a primary extraction layer and at least one secondary extraction layer disposed on one side of the primary extraction layer or on two opposite sides of the primary extraction layer, and the primary extraction layer has a refractive index greater than that of the secondary extraction layer; and the secondary extraction layer has a refractive index greater than that of the barrier layer.

Abstract: A display panel, a display module and a display device. The display panel comprises a substrate, a light emitting device layer disposed on one side of the substrate, a light extraction layer assembly disposed on the side of the light emitting device layer facing away from the substrate and an encapsulation structure wherein the light extraction layer assembly comprises at least two light extraction layers arranged in a stacked configuration, and the at least two light extraction layers comprise a primary extraction layer and at least one secondary extraction layer disposed on one side or two opposite sides of the primary extraction layer, and a refractive index n5 of the primary extraction layer is greater than a refractive index of the secondary extraction layer.

Abstract: A culture composition for expanding a TIL, containing IL-2, IL-7, IL-15, and an immune checkpoint antibody or an antigen-binding fragment thereof. The immune checkpoint antibody comprises any one or more of a PD-1 antibody, a CTLA-4 antibody, a LAG-3 antibody, a TIM-3 antibody, a TIGIT antibody, and a BTLA antibody. The present invention further relates to a TIL expanding culture medium, a method for preparing a TIL population, and a pharmaceutical composition. In the culture composition, cell proliferation and activity are ensured while greatly reducing the used amount of IL-2, and IL-2 treatment is removed after infusing the TILs obtained using the culture composition into a patient so as to reduce side effects; moreover, no feeder cells are used in an expansion process, exogenous pollution is reduced and the manufacturing process is simplified, the manufacturing costs reduced, and the manufacturing time shortened.

Abstract: Disclosed in the present invention are a false eyelash pre-applied with glue, a glue pre-application device and a method for producing the false eyelash pre-applied with glue. The false eyelash pre-applied with glue comprises a false eyelash body and an eyelash bonding portion; the false eyelash body comprises an eyelash stem and a plurality of false eyelashes connected thereto, the false eyelashes bending toward upper surfaces of the false eyelashes; the eyelash bonding portion extends along a length direction of the eyelash stem and is arranged on the upper surfaces of the plurality of false eyelashes near the eyelash stem, and the eyelash bonding portion is configured to bond the false eyelash body to a real eyelash from below the real eyelash.

Abstract: A pharmaceutical composition, containing chloroquine or a derivative thereof and a tumor cell killing agent, and a pharmaceutically acceptable excipient. Also provided is a use of chloroquine or a derivative thereof in preparation of a medication for treating a tumor.

Abstract: A method for signal separation includes obtaining list mode data representing radiation detected during an imaging scan, the list mode data being affected by quasi-periodic motion of an imaging object; dividing the list mode data into first non-overlapping frames of a first frame length, and process the first frames to determine a cardiac cycle length; determining a second frame length, longer than the first frame length, based on the determined cardiac cycle length; re-binning the list mode data into overlapping frames having the second frame length, based on the non-overlapping frames having the first frame length; applying a principal component analysis (PCA) process on the re-binned list mode data having the second frame length to determine a respiratory waveform; determining a cardiac waveform using the determined respiratory waveform; and reconstructing an image based on the list mode data using the determined respiratory waveform and the determined cardiac waveform.

Abstract: A method for performing single gating in a positron emission tomography (PET) system includes: receiving list-mode data acquired by scanning an imaging object using the PET system, the list-mode data being affected by quasi-periodic motion of the imaging object; producing a plurality of vectors based on the received list-mode data; generating a reference vector based on the produced plurality of vectors; selecting, from the produced plurality of vectors, a set of vectors corresponding to a single gate, based on respective differences compared with the generated reference vector; and generating an image of the imaging object based on the selected set of vectors.

Abstract: Disclosed in the present invention are a false eyelash pre-applied with glue, a glue pre-application device and a method for producing the false eyelash pre-applied with glue. The false eyelash pre-applied with glue comprises a false eyelash body and an eyelash bonding portion; the false eyelash body comprises an eyelash stem and a plurality of false eyelashes connected thereto, the false eyelashes bending toward upper surfaces of the false eyelashes; the eyelash bonding portion extends along a length direction of the eyelash stem and is arranged on the upper surfaces of the plurality of false eyelashes near the eyelash stem, and the eyelash bonding portion is configured to bond the false eyelash body to a real eyelash from below the real eyelash.

Abstract: The present invention provides a high-efficient magnesium ion removal system for salt lake brine based on in situ alkali production using bipolar membrane electrochemical process, it is constructed with cathode, cathode cell, anode, anode cell, and anion exchange membranes, bipolar membranes, acid cells, alkali cells, mesh materials for precipitate aggregation, acid-washing cells.

Abstract: The present invention belongs to the field of alkaline polymer electrolyte membranes, and relates to a comb-shaped structure polybenzimidazole anion exchange membrane with high conductivity and preparation method thereof. In the invention, firstly, polybenzimidazole is grafted with the non-cationic side chains to the max grafting rate to synthesize the de-protonated comb-shaped polybenzimidazole material, avoiding the N—H in benzimidazole forms ionic binding with cationic functional groups, which will reduce the reactivity and mobility of cationic groups; then react de-protonated comb-shaped polybenzimidazole with quaternization reagent to attach the pendent side chain with cationic functional groups, making it easy to aggregate to form ion clusters and hydrophilic/hydrophobic microphase separation. The anion exchange membrane prepared in this invention has excellent conductivity, mechanical properties and alkaline stability.

Abstract: A method, apparatus, and computer instructions stored on a computer-readable medium perform latent image feature extraction by performing the functions of receiving image data acquired during an imaging of a patient, wherein the image data includes motion by the patient during the imaging; segmenting the image data to include M image data segments corresponding to at least N motion phases having shorter durations than a duration of the motion by the patient during the imaging, wherein M is a positive integer greater than or equal to a positive integer N; producing, from the M image data segments, at least N latent feature vectors corresponding to the motion by the patient during the imaging; and performing a gated reconstruction of the N motion phases by reconstructing the image data based on the at least N latent feature vectors.

Abstract: A method, apparatus, and non-transitory computer-readable storage medium for image denoising whereby a deep image prior (DIP) neural network is trained to produce a denoised image by inputting the second medical image to the DIP neural network and combining a converging noise and an output of the DIP network during the training such that the converging noise combined with the output of the DIP network approximates the first medical image at the end of the training, wherein the output of the DIP network represents the denoised image.

Abstract: Provided in the present disclosure are a bifunctional protein which can bind to PD-1 (programmed death receptor-1) and TGF-? (transforming growth factor-?), the medical use of the bifunctional protein, and a preparation method therefor.

Abstract: A seed cell medium of a tumor-infiltrating lymphocyte and an application thereof. The medium contains a cell culture component, a cell factor, and an immune checkpoint antibody or an antigen-binding fragment thereof. The cell factor includes IL-2; an immune checkpoint includes PD-1, LAG-3, TIGIT, and/or CTLA-4; and the cell culture component is a serum medium or a serum-free medium. The seed cell medium accelerates a culture of a seed cell of the tumor-infiltrating lymphocyte and shortens the amplification time required by the tumor-infiltrating lymphocyte.

Abstract: A method, system, and computer readable medium to perform nuclear medicine scatter correction estimation, sinogram estimation and image reconstruction from emission and attenuation correction data using deep convolutional neural networks. In one embodiment, a Deep Convolutional Neural network (DCNN) is used, although multiple neural networks can be used (e.g., for angle-specific processing). In one embodiment, a scatter sinogram is directly estimated using a DCNN from emission and attenuation correction data. In another embodiment a DCNN is used to estimate a scatter-corrected image and then the scatter sinogram is computed by a forward projection.