Abstract: The disclosure provides at compounds of Formula I, compositions comprising the same, and methods of using the same, including use in treating diseases, disorders of conditions mediated by the signaling of formyl peptide receptor 1 (FPR1).

Abstract: Compounds of Formula I, compositions comprising the same, and methods of using the same, including use in treating diseases, disorders of conditions mediated by the signaling of formyl peptide receptor 1 (FPR1).

Abstract: The present disclosure provides a plurality of the compounds. The compounds are capable of inhibiting Cathepsin L (CatL). A composition including at least one of these compounds is also provided. A method for treating or preventing one or more CatL-related diseases in a subject is further provided. The method may include administering the composition to the subject.

Abstract: Disclosed herein is a system and method for energy generation from salinity gradients using asymmetrically porous electrodes. In certain embodiments, an energy generation system includes at least one pair of asymmetrically porous electrodes positioned within a chamber in selective fluidic communication with a freshwater source (e.g., a river) and a saltwater source (e.g., an ocean). Asymmetry between a first average percent volume per unit pore-width of a first electrode and a second average percent volume per unit pore-width of a second electrode creates differing interfacial potentials between the first electrode and the second electrode when such electrodes are immersed in freshwater and saltwater. By cyclically immersing the electrodes in freshwater and saltwater, energy is harvested from Gibbs free energy from mixing saltwater and freshwater. Such a system does not require a membrane or an external charge source. Methods of generating energy using asymmetrically porous electrodes are also provided.

Abstract: A self-charging droplet capacitor for harvesting low-level ambient energy is provided. The capacitor includes a conductive liquid droplet, which is placed on a heterogeneous and hydrophobic surface of dielectric materials coated onto a conductive substrate. The substrate and the droplet, along with the dielectric materials in between, form a parallel-plate type capacitor. The droplet is free to move on the surface, and thus, provides a position-dependent variation of capacitance. The surface consists of two regions, each with a different material and thickness. The different strengths of solid-water contact electrification of the two materials give rise to a self-charging mechanism. The variation in thickness allows for the capacitance change required for energy harvesting.

Abstract: The present disclosure provides a compound configured to release nitric oxide (NO) and inhibit the activity of a phosphodiesterase (PDE) when administered to a subject. The compound may include L1 and L2. L1 may include a functional group that is part or all of a NO releasing agent. L2 may include a functional group that is part or all of a PDE inhibitor. The compound may further include a bond or a biradical that connects L1 and L2. The present disclosure further provides a method of treating or preventing a disease using the compound or a composition including the compound.

Abstract: The present invention provides a compound of formula or a pharmaceutical salt thereof, use, methods for its preparation are described.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutical salt thereof, use, methods for its preparation are described.

Abstract: Disclosed herein is a system and method for energy generation from salinity gradients using asymmetrically porous electrodes. In certain embodiments, an energy generation system includes at least one pair of asymmetrically porous electrodes positioned within a chamber in selective fluidic communication with a freshwater source (e.g., a river) and a saltwater source (e.g., an ocean). Asymmetry between a first average percent volume per unit pore-width of a first electrode and a second average percent volume per unit pore-width of a second electrode creates differing interfacial potentials between the first electrode and the second electrode when such electrodes are immersed in freshwater and saltwater. By cyclically immersing the electrodes in freshwater and saltwater, energy is harvested from Gibbs free energy from mixing saltwater and freshwater. Such a system does not require a membrane or an external charge source. Methods of generating energy using asymmetrically porous electrodes are also provided.

Abstract: A compound of the Formula (1) is below provided where R1-R5 are as described in the description and each “*” represents a chiral center.

Abstract: A compound of the Formula (1) is below provided where R1-R5 are as described in the description and each “*” represents a chiral center.

Abstract: Apparatuses and methods for harvesting ambient energy involve repeated circuit reconfiguration. An apparatus includes a primary charge storage device, a first secondary charge storage device, a second secondary charge storage device, and switching circuitry. The switching circuitry is configured to cyclically alter connection of the first and second secondary charge storage devices between a series state and a parallel state. First and second moveable electrically conductive elements may include electrically conductive liquid droplets of materials such as water or mercury. At least one of the primary storage device, the first secondary charge storage device, or the second secondary charge storage device includes a capacitance that varies in response to receipt of ambient energy. Concurrently altering relative capacitance and circuit configuration results in exponential growth of harvested energy.

Abstract: Systems, apparatuses and methods for harvesting ambient energy involve an electrically conductive charge-carrying movable electrode. An apparatus includes an electrically conductive charge-carrying electrode, a first dielectric interface region, a second dielectric interface region, and at least one reference electrode. The first and second dielectric interface regions differ in surface charge density. In certain aspects, the movable electrode moves proximate and relative to the first and second dielectric interface regions in response to receipt of ambient energy, thereby providing first and second capacitances. The first capacitance differs from the second capacitance, and/or the first surface charge density differs from the second surface charge density. Movement of the movable electrode in combination with the differing capacitances and/or charge densities results in energy accumulation, thereby enabling ambient energy to be harvested efficiently and effectively.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutical salt thereof, use, methods for its preparation are described.

Abstract: Apparatuses and methods for harvesting ambient energy involve repeated circuit reconfiguration. An apparatus includes a primary charge storage device, a first secondary charge storage device, a second secondary charge storage device, and switching circuitry. The switching circuitry is configured to cyclically alter connection of the first and second secondary charge storage devices between a series state and a parallel state. First and second moveable electrically conductive elements may include electrically conductive liquid droplets of materials such as water or mercury. At least one of the primary storage device, the first secondary charge storage device, or the second secondary charge storage device includes a capacitance that varies in response to receipt of ambient energy. Concurrently altering relative capacitance and circuit configuration results in exponential growth of harvested energy.

Abstract: Systems, apparatuses and methods for harvesting ambient energy involve an electrically conductive charge-carrying movable electrode. An apparatus includes an electrically conductive charge-carrying electrode, a first dielectric interface region, a second dielectric interface region, and at least one reference electrode. The first and second dielectric interface regions differ in surface charge density. In certain aspects, the movable electrode moves proximate and relative to the first and second dielectric interface regions in response to receipt of ambient energy, thereby providing first and second capacitances. The first capacitance differs from the second capacitance, and/or the first surface charge density differs from the second surface charge density. Movement of the movable electrode in combination with the differing capacitances and/or charge densities results in energy accumulation, thereby enabling ambient energy to be harvested efficiently and effectively.

Abstract: The present invention provides compounds of the Formula below wherein R, R1-R3 are as described herein; methods of treating patients for diabetes using the compounds, and processes for preparing the compounds.

Abstract: The present invention provides compounds of the Formula below wherein R, R1-R3 are as described herein; methods of treating patients for diabetes using the compounds, and processes for preparing the compounds

Abstract: The present invention provides compounds of the Formula (Ia) wherein R is selected from the group consisting of CH3, CH(CH3)2, CH2CN, CH2CHF2, CH2CF3, (A), (B), (C), (D), (E), (F), CH2CH2OCH3, and CH2C(O)OCH(CH3)2; R1 is selected from the group consisting of CF3, OCF3, and Cl; R2 is selected from the group consisting of H and F; or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides compounds of the Formula (Ia) wherein R is selected from the group consisting of CH3, CH(CH3)2, CH2CN, CH2CHF2, CH2CF3, (A), (B), (C), (D), (E), (F), CH2CH2OCH3, and CH2C(O)OCH(CH3)2; R1 is selected from the group consisting of CF3, OCF3, and Cl; R2 is selected from the group consisting of H and F; or a pharmaceutically acceptable salt thereof.