Patents by Inventor Tianwei Ma

Tianwei Ma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240018124
    Abstract: Compounds of Formula I, compositions comprising the same, and methods of using the same, including use in treating diseases, disorders of conditions mediated by the signaling of formyl peptide receptor 1 (FPR1).
    Type: Application
    Filed: March 17, 2022
    Publication date: January 18, 2024
    Inventors: Tianwei MA, Feng SHI, Lichao FANG, Zheng HUANG, Hua Viola LIN, Yue XIAO
  • Patent number: 11858905
    Abstract: The present disclosure provides a plurality of the compounds. The compounds are capable of inhibiting Cathepsin L (CatL). A composition including at least one of these compounds is also provided. A method for treating or preventing one or more CatL-related diseases in a subject is further provided. The method may include administering the composition to the subject.
    Type: Grant
    Filed: March 31, 2023
    Date of Patent: January 2, 2024
    Assignees: BIOFRONT THERAPEUTICS (BEIJING) CO., LTD., RK PHARMTECH (BEIJING) LTD.
    Inventors: Lichao Fang, Yayi Wang, Tianwei Ma, Ling Song, Zheng Huang, Jin-Kui Yang, Shuo Gu
  • Patent number: 11742509
    Abstract: Disclosed herein is a system and method for energy generation from salinity gradients using asymmetrically porous electrodes. In certain embodiments, an energy generation system includes at least one pair of asymmetrically porous electrodes positioned within a chamber in selective fluidic communication with a freshwater source (e.g., a river) and a saltwater source (e.g., an ocean). Asymmetry between a first average percent volume per unit pore-width of a first electrode and a second average percent volume per unit pore-width of a second electrode creates differing interfacial potentials between the first electrode and the second electrode when such electrodes are immersed in freshwater and saltwater. By cyclically immersing the electrodes in freshwater and saltwater, energy is harvested from Gibbs free energy from mixing saltwater and freshwater. Such a system does not require a membrane or an external charge source. Methods of generating energy using asymmetrically porous electrodes are also provided.
    Type: Grant
    Filed: June 23, 2020
    Date of Patent: August 29, 2023
    Assignee: University of Hawaii
    Inventors: Tianwei Ma, Jian Yu
  • Publication number: 20230188056
    Abstract: A self-charging droplet capacitor for harvesting low-level ambient energy is provided. The capacitor includes a conductive liquid droplet, which is placed on a heterogeneous and hydrophobic surface of dielectric materials coated onto a conductive substrate. The substrate and the droplet, along with the dielectric materials in between, form a parallel-plate type capacitor. The droplet is free to move on the surface, and thus, provides a position-dependent variation of capacitance. The surface consists of two regions, each with a different material and thickness. The different strengths of solid-water contact electrification of the two materials give rise to a self-charging mechanism. The variation in thickness allows for the capacitance change required for energy harvesting.
    Type: Application
    Filed: April 30, 2021
    Publication date: June 15, 2023
    Inventors: Tianwei Ma, Jian Yu
  • Publication number: 20230174482
    Abstract: The present disclosure provides a compound configured to release nitric oxide (NO) and inhibit the activity of a phosphodiesterase (PDE) when administered to a subject. The compound may include L1 and L2. L1 may include a functional group that is part or all of a NO releasing agent. L2 may include a functional group that is part or all of a PDE inhibitor. The compound may further include a bond or a biradical that connects L1 and L2. The present disclosure further provides a method of treating or preventing a disease using the compound or a composition including the compound.
    Type: Application
    Filed: January 30, 2023
    Publication date: June 8, 2023
    Applicant: BIOFRONT THERAPEUTICS (BEIJING) CO., LTD.
    Inventors: Zheng HUANG, Tianwei MA
  • Publication number: 20220281845
    Abstract: The present invention provides a compound of formula or a pharmaceutical salt thereof, use, methods for its preparation are described.
    Type: Application
    Filed: May 18, 2022
    Publication date: September 8, 2022
    Inventors: Tianwei Ma, Liang Wu, Xuejun Zhang
  • Patent number: 11365185
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutical salt thereof, use, methods for its preparation are described.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: June 21, 2022
    Assignee: Eli Lilly and Company
    Inventors: Tianwei Ma, Liang Wu, Xuejun Zhang
  • Publication number: 20220158216
    Abstract: Disclosed herein is a system and method for energy generation from salinity gradients using asymmetrically porous electrodes. In certain embodiments, an energy generation system includes at least one pair of asymmetrically porous electrodes positioned within a chamber in selective fluidic communication with a freshwater source (e.g., a river) and a saltwater source (e.g., an ocean). Asymmetry between a first average percent volume per unit pore-width of a first electrode and a second average percent volume per unit pore-width of a second electrode creates differing interfacial potentials between the first electrode and the second electrode when such electrodes are immersed in freshwater and saltwater. By cyclically immersing the electrodes in freshwater and saltwater, energy is harvested from Gibbs free energy from mixing saltwater and freshwater. Such a system does not require a membrane or an external charge source. Methods of generating energy using asymmetrically porous electrodes are also provided.
    Type: Application
    Filed: June 23, 2020
    Publication date: May 19, 2022
    Inventors: Tianwei MA, Jian YU
  • Patent number: 11214562
    Abstract: A compound of the Formula (1) is below provided where R1-R5 are as described in the description and each “*” represents a chiral center.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: January 4, 2022
    Assignee: ELI LILLY AND COMPANY
    Inventors: Zhi Long Hu, Lian Zhu Liu, Tianwei Ma, Mi Zeng, Haizhen Zhang
  • Publication number: 20210292302
    Abstract: A compound of the Formula (1) is below provided where R1-R5 are as described in the description and each “*” represents a chiral center.
    Type: Application
    Filed: July 17, 2017
    Publication date: September 23, 2021
    Inventors: Zhi Long Hu, Lian Zhu Liu, Tianwei Ma, Mi Zeng, Haizhen Zhang
  • Patent number: 10873276
    Abstract: Apparatuses and methods for harvesting ambient energy involve repeated circuit reconfiguration. An apparatus includes a primary charge storage device, a first secondary charge storage device, a second secondary charge storage device, and switching circuitry. The switching circuitry is configured to cyclically alter connection of the first and second secondary charge storage devices between a series state and a parallel state. First and second moveable electrically conductive elements may include electrically conductive liquid droplets of materials such as water or mercury. At least one of the primary storage device, the first secondary charge storage device, or the second secondary charge storage device includes a capacitance that varies in response to receipt of ambient energy. Concurrently altering relative capacitance and circuit configuration results in exponential growth of harvested energy.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: December 22, 2020
    Assignee: UNIVERSITY OF HAWAII
    Inventors: Tianwei Ma, Jian Yu, Enze Ma
  • Patent number: 10848079
    Abstract: Systems, apparatuses and methods for harvesting ambient energy involve an electrically conductive charge-carrying movable electrode. An apparatus includes an electrically conductive charge-carrying electrode, a first dielectric interface region, a second dielectric interface region, and at least one reference electrode. The first and second dielectric interface regions differ in surface charge density. In certain aspects, the movable electrode moves proximate and relative to the first and second dielectric interface regions in response to receipt of ambient energy, thereby providing first and second capacitances. The first capacitance differs from the second capacitance, and/or the first surface charge density differs from the second surface charge density. Movement of the movable electrode in combination with the differing capacitances and/or charge densities results in energy accumulation, thereby enabling ambient energy to be harvested efficiently and effectively.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: November 24, 2020
    Assignee: UNIVERSITY OF HAWAII
    Inventors: Tianwei Ma, Jian Yu, Enze Ma
  • Publication number: 20200231568
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutical salt thereof, use, methods for its preparation are described.
    Type: Application
    Filed: August 28, 2018
    Publication date: July 23, 2020
    Inventors: Tianwei Ma, Liang Wu, Xuejun Zhang
  • Publication number: 20190280620
    Abstract: Apparatuses and methods for harvesting ambient energy involve repeated circuit reconfiguration. An apparatus includes a primary charge storage device, a first secondary charge storage device, a second secondary charge storage device, and switching circuitry. The switching circuitry is configured to cyclically alter connection of the first and second secondary charge storage devices between a series state and a parallel state. First and second moveable electrically conductive elements may include electrically conductive liquid droplets of materials such as water or mercury. At least one of the primary storage device, the first secondary charge storage device, or the second secondary charge storage device includes a capacitance that varies in response to receipt of ambient energy. Concurrently altering relative capacitance and circuit configuration results in exponential growth of harvested energy.
    Type: Application
    Filed: November 17, 2017
    Publication date: September 12, 2019
    Inventors: Tianwei Ma, Jian Yu, Enze Ma
  • Publication number: 20190280621
    Abstract: Systems, apparatuses and methods for harvesting ambient energy involve an electrically conductive charge-carrying movable electrode. An apparatus includes an electrically conductive charge-carrying electrode, a first dielectric interface region, a second dielectric interface region, and at least one reference electrode. The first and second dielectric interface regions differ in surface charge density. In certain aspects, the movable electrode moves proximate and relative to the first and second dielectric interface regions in response to receipt of ambient energy, thereby providing first and second capacitances. The first capacitance differs from the second capacitance, and/or the first surface charge density differs from the second surface charge density. Movement of the movable electrode in combination with the differing capacitances and/or charge densities results in energy accumulation, thereby enabling ambient energy to be harvested efficiently and effectively.
    Type: Application
    Filed: November 29, 2017
    Publication date: September 12, 2019
    Inventors: Tianwei Ma, Jian Yu, Enze Ma
  • Patent number: 10196385
    Abstract: The present invention provides compounds of the Formula below wherein R, R1-R3 are as described herein; methods of treating patients for diabetes using the compounds, and processes for preparing the compounds.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: February 5, 2019
    Assignee: Eli Lilly and Company
    Inventors: Zhi Long Hu, Lian Zhu Liu, Tianwei Ma, Haizhen Zhang, Jingye Zhou
  • Publication number: 20180194755
    Abstract: The present invention provides compounds of the Formula below wherein R, R1-R3 are as described herein; methods of treating patients for diabetes using the compounds, and processes for preparing the compounds
    Type: Application
    Filed: February 19, 2016
    Publication date: July 12, 2018
    Inventors: Zhi Long Hu, Lian Zhu Liu, Tianwei Ma, Haizhen Zhang, Jingye Zhou
  • Patent number: 9861613
    Abstract: The present invention provides compounds of the Formula (Ia) wherein R is selected from the group consisting of CH3, CH(CH3)2, CH2CN, CH2CHF2, CH2CF3, (A), (B), (C), (D), (E), (F), CH2CH2OCH3, and CH2C(O)OCH(CH3)2; R1 is selected from the group consisting of CF3, OCF3, and Cl; R2 is selected from the group consisting of H and F; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 22, 2015
    Date of Patent: January 9, 2018
    Assignee: Eli Lilly and Company
    Inventors: Zhi Long Hu, Lian Zhu Liu, Tianwei Ma, Mi Emily Zeng, Jingye Zhou
  • Publication number: 20170165234
    Abstract: The present invention provides compounds of the Formula (Ia) wherein R is selected from the group consisting of CH3, CH(CH3)2, CH2CN, CH2CHF2, CH2CF3, (A), (B), (C), (D), (E), (F), CH2CH2OCH3, and CH2C(O)OCH(CH3)2; R1 is selected from the group consisting of CF3, OCF3, and Cl; R2 is selected from the group consisting of H and F; or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: January 22, 2015
    Publication date: June 15, 2017
    Inventors: Zhi Long Hu, Lian Zhu Liu, Tianwei Ma, Mi Emily Zeng, Jingye Zhou
  • Patent number: 8106077
    Abstract: Compounds of formula (I) wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.
    Type: Grant
    Filed: May 22, 2007
    Date of Patent: January 31, 2012
    Assignee: Eli Lilly and Company
    Inventors: Michael Gregory Bell, Robert Anthony Doti, Matthew Scott Dowling, Michael James Genin, Peter Ambrose Lander, Tianwei Ma, Nathan Bryan Mantlo, Jason Matthew Ochoada, Lindsay Scott Stelzer, Ryan Edward Stites, Alan M Warshawsky