Patents by Inventor Tianyan Liu

Tianyan Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RECOMBINANT NEWCASTLE DISEASE VIRUS RNDV-VEGF-TRAP, GENOME THEREOF, PREPARATION METHOD THEREFOR, AND USE THEREOF
    Publication number: 20240124852
    Abstract: The present application discloses a recombinant Newcastle disease virus genome, a recombinant Newcastle disease virus rNDV-VEGF-Trap containing the genome and a preparation method therefor, a DNA molecule encoding the recombinant Newcastle disease virus genome, and a use of the genome and the recombinant Newcastle disease virus in the preparation of a drug for treating cancer. The recombinant Newcastle disease virus provided by the present application relates to inserting a coding gene of VEGF-Trap into the genome of the recombinant Newcastle disease virus, such that the recombinant Newcastle disease virus obtained therefrom is replicated with a strong replication capability, thereby killing host cancer cells; moreover, the recombinant Newcastle disease virus has reliable safety for non-cancer cells, and shows improved anti-tumor effect and oncolytic efficiency.
    Type: Application
    Filed: April 13, 2022
    Publication date: April 18, 2024
    Inventors: Wei Xiao, Deshan Li, Tianyan Liu, Zhenzhong Wang, Yukai Cao, Zhihang Liu, Dan Yu
  • RECOMBINANT NEWCASTLE DISEASE VIRUS AND PREPARATION METHOD THEREFOR, RECOMBINANT PLASMID, AND USE THEREOF
    Publication number: 20230203454
    Abstract: A recombinant Newcastle disease virus and a preparation method therefor, a recombinant plasmid, and use thereof. The recombinant Newcastle disease virus is obtained by replacing an F protein of a Newcastle disease virus lasota with an F protein of a Newcastle disease virus virulent strain. The recombinant chimeric virus has good safety and is capable of effectively inhibiting tumour cells, promoting tumour cell apoptosis, and effectively treating a tumour.
    Type: Application
    Filed: May 21, 2021
    Publication date: June 29, 2023
    Applicant: JIANGSU KANIONREAL BIOMEDICAL TECHNOLOGY CO., LTD
    Inventors: Wei XIAO, Deshan LI, Tianyan LIU, Zhihang LIU, Zhenzhong WANG, Shan JIANG, Xiaolian HE, Xuehong DONG, Yanqiu WANG
  • Method for establishing an expression system of spider dragline silk gene in bombyx mori
    Patent number: 6872869
    Abstract: The present invention provides a method for establishing an expression system of spider dragline silk gene in Bombyx mori. The rate of transformation is about 0.5-1%. In the silk protein produced by the transgenic Bombyx mori obtained by the method of the present invention, the spider dragline silk gene product account for 30% of the total silk proteins.
    Type: Grant
    Filed: October 4, 2001
    Date of Patent: March 29, 2005
    Assignee: Chengdu Tianchuang Bio-Tech Co., Ltd.
    Inventors: Tianyan Liu, Huifen Liu, Wei Li, Libin Zhao
  • Method for establishing an expression system of spider dragline silk gene in bombyx mori
    Publication number: 20020137211
    Abstract: The present invention provides a method for establishing an expression system of spider dragline silk gene in Bombyx mori. The rate of transformation is about 0.5-1%. In the silk protein produced by the transgenic Bombyx mori obtained by the method of the present invention, the spider dragline silk gene product account for 30% of the total silk proteins.
    Type: Application
    Filed: October 4, 2001
    Publication date: September 26, 2002
    Applicant: Sichuan University Tianyou Biologic Engineering Co. LTD.
    Inventors: Tianyan Liu, Huifen Liu, Wei Li, Libin Zhao