Abstract: The present invention provides gemcitabine anticancer derivatives of formula (III), which have the potential to be developed into AKR1C3-activated anticancer drugs, and the anticancer pharmaceutical use thereof,.

Abstract: Provided are the use of the compound 1-(3-(3-N,N-dimethylaminocarbonyl)phenoxyl-4-mtrophenyl)-1-ethyl-N,N?-bis(ethylene)phosphoramidate, or a pharmaceutically acceptable salt, isotopic variant or solvate thereof in the manufacture of a medicament for treating cancer, and a composition which comprises the above compound and at least one anti-cancer drug.

Abstract: Described are hypoxia-activated DNA alkylating agents having any one of the following structural formulas, or a pharmaceutically acceptable salt, a prodrug, a solvate or an isotopic variant thereof, as well as an anticancer medical use thereof.

Abstract: A method is provided for handling resources for uplink semi-persistent scheduling transmission, wherein the resources are reserved periodically for a specific service, the method including monitoring data transmitted on the semi-persistent scheduling reserved resources and dynamic scheduled resource, checking whether a specific data element related to the specific service has not been received consecutively for a predefined period on the semi-persistent scheduling reserved resources and dynamic scheduled resource, and determining, when the specific data element has not been received for the predefined period, that the use of the specific service has ended. When it is determined that the use of the specific service has ended, an explicit release for the semi-persistent scheduling reserved resources may be triggered.