Patents by Inventor Tianzuo Zhang

Tianzuo Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • S-adenosylmethionine synthetase mutants, the DNAs encoding the same and uses of the mutants
    Patent number: 7858351
    Abstract: The invention discloses a series of Methanococcus jannaschii S-adenosylmethionine synthetase mutants with improved thermostability and high catalytic activity obtained by using gene mutation technique, characterized in that these mutants refer to an enzyme using Sequence 2 in the Sequence Listing as the reference sequence and contains at least one mutation at position 102, position 93, position 230, and position 357 and has a catalytic activity at least 70% higher than that of the wild-type S-adenosylmethionine synthetase using adenosine triphosphate (ATP) and methionine as substrates. These S-adenosylmethionine synthetase mutants can be used in the production of S-adenosylmethionine.
    Type: Grant
    Filed: August 30, 2007
    Date of Patent: December 28, 2010
    Assignee: Geneharbor ( Hong Kong) Technologies, Ltd.
    Inventors: Rongzhao Fu, Tianzuo Zhang, Jun Wang
  • S-Adenosylmethionine Synthetase Mutants, the DNAs Encoding the Same and Uses of the Mutants
    Publication number: 20090203080
    Abstract: The invention discloses a series of Methanococcus jannaschii S-adenosylmethionine synthetase mutants with improved thermostability and high catalytic activity obtained by using gene mutation technique, characterized in that these mutants refer to an enzyme using Sequence 2 in the Sequence Listing as the reference sequence and contains at least one mutation at position 102, position 93, position 230, and position 357 and has a catalytic activity at least 70% higher than that of the wild-type S-adenosylmethionine synthetase using adenosine triphosphate (ATP) and methionine as substrates. These S-adenosylmethionine synthetase mutants can be used in the production of S-adenosylmethionine.
    Type: Application
    Filed: August 30, 2007
    Publication date: August 13, 2009
    Applicant: GENEHARBOR (HONG KONG) TECHNOLOGIES LTD.
    Inventors: Rongzhao Fu, Tianzuo Zhang, Jun Wang