Abstract: A silicone adhesive is shown and described herein. The silicone adhesive composition comprises a silicone resin, a silicone fluid, and an aminosilane. The aminosilane contains two or more amino groups, where the amino groups can be bound to a single silicon atom or may be bound to separate silicon atoms in a silicon core unit. The silicone adhesive compositions are suitable for use as hot melt adhesives and can be used to coat or otherwise encapsulate an article.

Abstract: Provided herein are agents that bind to soluble beta-amyloid. Also provided are in vivo and in vitro methods for detecting soluble beta-amyloid in a sample that may include brain tissue.

Abstract: Provided herein are agents that bind to soluble beta-amyloid. Also provided are in vivo and in vitro methods for detecting soluble beta-amyloid in a sample that may include brain tissue.

Abstract: A method of labeling amino acid-containing compounds and derivatives thereof with a halide moiety comprises reacting a nucleophilic moiety on such compounds with a halogenated electrophilic compound. Radioactive halide-labeled amino acid-containing compounds can be targeted to diseased sites and provide a means to diagnose and/or treat the disease.

Abstract: Compounds that include a targeting moiety bound to a regioselective leaving group are useful for preparing imaging agents. The imaging agents can be isolated from by-products derived from the leaving group based on differences in the chemical attributes (e.g., net charge or polarity) of the molecules or physical attributes of the molecules through the use of a solid support. Methods of producing an imaging agent include the steps of providing a compound that includes a targeting moiety bound to a support via a linker group that contains a site for regioselective substitution of a detectable species, contacting the compound with a solution containing the detectable species, and recovering the imaging agent.