Patents by Inventor Tibor Klupp

Tibor Klupp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Plasmids and process for producing recombinant desulphatohirudin HV-1 peptides
    Patent number: 5552299
    Abstract: The present invention relates to a process for producing recombinant desulphatohirudin by means of culturing microorganisms.Concerning the codon usage of microorganisms the synthesized nucleotide sequences were joined downstream of and in reading frame with isolated promoters and signal sequences, subsequently the expression/secretion cassettes comprising the foregoing elements were inserted into plasmid DNAs allowing the cultivation of cells under selective culture conditions. E. coli, Saccharomyces and Streptomyces species were transformed with the said recombinant plasmids to biosynthesize the thrombin inhibitor desulphatohirudin HV-1 which was then isolated and identified.The thus-produced desulphatohirudin can be used to inhibit blood coagulation.
    Type: Grant
    Filed: April 9, 1993
    Date of Patent: September 3, 1996
    Assignee: Biogal Gyogyszergyar Rt.
    Inventors: Istv an Ott, Tibor Klupp, Istv an Moln ar, Andr as Patthy, Istv an Barta, Zsuzsa Bark o n ee T oth, G abor Ambrus, J anos Sal at, Anik o Tegdes, Imre Moravcsik, Cecilia Egy ud, K arnly Albrecht, K alm an K oncz ol, Attila Vincze, Eva Barab as, Gy orgy M at e, Gy orgy B. Kiss, P eter Kiss, K alm an P olya, J anos Erdei, Eva Guly as, Erika Zilahi
  • Process for the preparation of a biologically active substance for selective inhibition of the proliferation of leukemic and normal myeloid cells
    Patent number: 4384991
    Abstract: The invention relates to a process for the preparation of a biologically active substance, which can be isolated from normal white blood cells and is capable of inhibiting the proliferation of normal and leukemic myeloid cells selectively.The substance obtained is a peptide, which has an amino acid composition of Tau.sub.1, Asx.sub.1, Ser.sub.2, Thr.sub.1, Glx.sub.3, Gly.sub.2, Ala.sub.1, (PO.sub.4).sub.1.sup.2-, a negative charge at pH 6.5, an electrophoretic mobility of -0.55 to -0.65 related to aspartic acid, has no charge at pH 1.9, has a mobility of about 0.26 related to .epsilon.-DNP-lysine and gives a positive chloro-toluidine reaction.
    Type: Grant
    Filed: January 8, 1981
    Date of Patent: May 24, 1983
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Andras Balazs, Mihaly Sajgo, Lajos Kisfaludy, Tibor Klupp, Kornelia Barabas nee Borbas