Patents by Inventor Tibor Kristian

Tibor Kristian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulation of Nad+ Activity in Neuropathophysiological Conditions and Uses Thereof
    Publication number: 20120328526
    Abstract: The present invention provides a method of treating a mammal having a neuropathophysiological condition, comprising the step of administering to the mammal in need of such treatment a compound selected from nicotinamide or salts or prodrugs thereof, nicotinamide mononucleotide or salts or prodrugs thereof, nicotinamide adenine dinucleotide or salts or prodrugs thereof, nicotinamide riboside nicotinamide or salts or prodrugs thereof, phosphoribosyltransferase, or combinations thereof. Further provided is a method for treating a mammal having a neuropathophysiological condition or suspected to develop said neuropathophysiological condition, comprising the step of administering to said mammal an inhibitor of CD38 NAD+ glycohydrolase activity.
    Type: Application
    Filed: June 26, 2012
    Publication date: December 27, 2012
    Inventor: Tibor Kristian
  • Assay for detecting changes in mitochondrial membrane permeability and method of using same
    Patent number: 7348135
    Abstract: An assay for assessing the permeability of mitochondrial membranes is provided. The assay is based on enzymatic reactions that produce a detectable signal in the presence of intra-mitochondrial compounds. In some embodiments, the intra-mitochondrial compounds may be reduced and/or oxidized nicotinamide adenine dinucleotides (i.e., NADH and NAD+, respectively). The assay may optionally be provided in the form of a kit, and may further be useful in the discovery and interrogation of compounds that may serve to inhibit pathologic increase in mitochondrial membrane permeability, which is associated with numerous and varied mammalian disease.
    Type: Grant
    Filed: August 26, 2004
    Date of Patent: March 25, 2008
    Assignee: University of Maryland
    Inventors: Tibor Kristian, Gary Fiskum
  • Assay for detecting changes in mitochondrial membrane permeability and method of using same
    Publication number: 20050048596
    Abstract: An assay for assessing the permeability of mitochondrial membranes is provided. The assay is based on enzymatic reactions that produce a detectable signal in the presence of intra-mitochondrial compounds. In some embodiments, the intra-mitochondrial compounds may be reduced and/or oxidized nicotinamide adenine dinucleotides (i.e., NADH and NAD+, respectively). The assay may optionally be provided in the form of a kit, and may further be useful in the discovery and interrogation of compounds that may serve to inhibit pathologic increase in mitochondrial membrane permeability, which is associated with numerous and varied mammalian disease.
    Type: Application
    Filed: August 26, 2004
    Publication date: March 3, 2005
    Applicant: University of Maryland
    Inventors: Tibor Kristian, Gary Fiskum