Abstract: Oral hygiene formulations incorporating N.sup.G -alkyl derivatives of arginine, or the pharmaceutically acceptable salts thereof, optionally in combination with fluoride compounds, are effective in combatting microorganisms, inhibiting acid production and reducing dental caries.

Abstract: Oral hygiene formulations incorporating N.sup.G -acyl derivatives of arginine, or the pharmaceutically acceptable salts thereof, optionally in combination with fluoride compounds, are effective in combatting microorganisms, inhibiting acid production and reducing dental caries.

Abstract: Oral hygiene formulations incorporating N.sup..alpha. -alkyl derivatives of arginine, or the pharmaceutically acceptable salts thereof, optionally in combination with fluoride compounds, are effective in combatting microorganisms, inhibiting acid production and reducing dental caries.

Abstract: Oral hygiene formulations incorporating N.sup..alpha.,N.sup.G -diacyl derivatives of arginine, or the pharmaceutically acceptable salts thereof, optionally in combination with fluoride compounds, are effective in combatting microorganisms, inhibiting acid production and reducing dental caries.

Abstract: Antimicrobial compositions are provided wherein there is obtained an enhancement of activity by combining the antimicrobial agent with an effective amount of a potentiator. The potentiator is selected from the group consisting of a primary, secondary and tertiary phenylalkanol, halophenylalkanol or C.sub.1 to C.sub.3 alkylphenylalkanol where the alkanol has from about 3 to about 9 carbon atoms.The compositions comprising an antimicrobial agent and a potentiating agent are useful as surgical scrub solutions and in dressing topical wounds where the presence of blood and wound exudate would otherwise inhibit the action of the antimicrobial agent if it were to be used alone.Also provided are topically active compositions wherein topical activity of a medicament is enhanced by combining the medicament with an effective amount of a potentiator as defined above. The topical compositions are useful as topical anesthetics, cell regulatory agents, antimicrobials, anti-inflammatory compositions, and the like.

Abstract: Compositions providing improved protection against dental caries consisting of a pharmaceutically acceptable fluoride compound and a pharmaceutically acceptable sulfonated polymeric material in a suitable vehicle are described.

Abstract: Compositions providing improved protection against dental caries consisting of a pharmaceutically acceptable fluoride compound and a pharmaceutically acceptable sulfonated alkylnaphthalene in a suitable vehicle are described.

Abstract: Compositions providing improved protection against dental caries consisting of a pharmaceutically acceptable fluoride compound and a pharmaceutically acceptable poly(vinylbenzoic acid) in a suitable vehicle are described.

Abstract: Compositions providing improved protection against dental caries consisting of a pharmaceutically acceptable fluoride compound and a pharmaceutically acceptable alkyl phenoxy or oxydibenzene sulfonate in a suitable vehicle are described.

Abstract: Improved protection against dental enamel caries is provided by applying to the teeth and gingivae an oral hygiene composition containing, in addition to a pharmaceutically acceptable fluoride compound, a sufficient quantity of a pharmaceutically acceptable zinc compound so that the ratio of zinc ion to fluoride ion is at least about 7:1 by weight.

Abstract: Compositions and methods for preventing the attachment of dental plaque to the surfaces of the teeth of mammals comprise certain sulfonated vinylaromatic homopolymers and copolymers and the pharmaceutically acceptable salts thereof in a pharmaceutically acceptable vehicle, and the periodic application thereof to teeth.

Abstract: Compositions and methods for preventing the attachment of dental plaque to the surfaces of the teeth of mammals comprises certain alkali metal salts of poly(vinylbenzoic acid) in pharmaceutically acceptable vehicles, and the periodic applications thereof to teeth.

Abstract: Compositions and methods for preventing the attachment of dental plaque to the surfaces of the teeth of mammals comprise condensation polymers of formaldehyde with naphthalene sulfonic acid as well as the pharmaceutically acceptable salts thereof in a pharmaceutically acceptable vehicle, and the periodic application thereof of teeth.

Abstract: Compositions and methods for preventing the attachment of dental plaque to the surfaces of the teeth of mammals comprise certain sulfonated aromatic formaldehyde condensation polymers and the pharmaceutically acceptable salts thereof in a pharmaceutically acceptable vehicle, and the periodic application thereof to teeth.

Abstract: Antimicrobial compositions are provided wherein there is obtained an enhancement of the activity of an antimicrobial agent exemplified by quarternary ammonium compounds, bisdiguanides, anti-fungal agents, phenols, hydroxydiphenyls, carbanilides, salicylanilides, organo-metallic antiseptics, antibiotics, halogens, organic halogen derivatives and iodophores derived from nonionic surface active agents and from polyvinylpyrrolidone by combining the antimicrobial agent with an effective amount of a potentiator. The potentiator is a cyclohexyl phenol which may have a substituent on the phenyl ring selected from the group consisting of C.sub.1 to C.sub.3 alkyl and alkoxy, hydroxy, halo, amino and alkyl and dialkyl amino-substituents.These novel compositions find special applications as surgical scrub solutions, and for use in dressing topical wounds where the presence of blood and wound exudate would otherwise inhibit the action of the antimicrobial agent if it were to be used alone.

Abstract: Polymers useful in compositions and methods for preventing the attachment of dental plaque to the surface of the teeth of mammals comprise certain sulfonated polyamino acids and salts thereof in a pharmaceutically acceptable vehicle and the periodic application thereof to teeth.

Abstract: Antimicrobial compositions are provided wherein there is obtained an enhancement of the activity of an antimicrobial agent exemplified by quaternary ammonium compounds, bisdiguanides, anti-fungal agents, phenols, hydroxydiphenyls, carbanilides, salicylanilides, organo-metallic antiseptics, antibiotics, halogens, organic halogen derivatives and iodophores derived from nonionic surface active agents and from polyvinylpyrrolidone by combining the antimicrobial agent with an effective amount of a potentiator.

Abstract: A glycerine solution of zinc chloride or another pharmaceutically acceptable zinc salt that is soluble in glycerine provides effective therapy for gingivitis when applied to the gingivae and teeth.

Abstract: Topical anesthetic compositions are provided wherein there is obtained an enhancement of the activity of the topical anesthetic agent by combining the anesthetic agent with an effective amount of a penetrant accelerator selected from the group consisting of the cyclohexyl substituted alkanols of the structure ##STR1## wherein R.sub.1 is C.sub.1 to C.sub.4 alkyl, halogen or hydrogen; R.sub.2 and R.sub.3 are independently selected from hydrogen, C.sub.1 to C.sub.3 alkyl, and cyclopropyl; and n is 1 to 4, provided that only one of R.sub.2 and R.sub.3 may be propyl or cyclopropyl.The topical anesthetic compositions of the invention are applied to the skin of an animal in order to induce anesthesia topically in the animal.

Abstract: Improved enteric coated digestive enzyme-containing compositions which are capable of withstanding hours of exposure to gastric fluids while protecting the biological activity of the enzymes and thereafter releasing the digestive enzymes in their biologically active state within 5 to 30 minutes after being exposed to intestinal fluids, these compositions comprising (a) an enzyme concentrate in (b) a binder system comprising at least about 0.5 wt. %, preferably about 1 to about 10 wt. % (based on the weight of the binder system plus enzymes) of (i) a binder, preferably selected from the group consisting of polyvinylpyrrolidone, microcrystalline cellulose (Avicel), cellulose acetate phthalate, methylcellulose and alginic acid, and preferably (ii) from about 0.1 to about 10 wt. % of a stabilizer, preferably selected from the group consisting of calcium carbonate, polyvinylpyrrolidone, cellulose acetate phthalate, methylcellulose, alginic acid, starch and modified starches, e.g.