Patents by Inventor Tie Q. Wei

Tie Q. Wei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250027947
    Abstract: Kits containing a chemiluminescent detection system and microfluidics devices and methods for determining the concentration of biotin in a sample are disclosed. The kits, microfluidics devices, and methods utilize a sensitizer capable of generating singlet oxygen in its excited state and having avidin or an analog thereof directly or indirectly bound thereto, as well as a singlet oxygen-activatable chemiluminescent compound having biotin or an analog thereof directly or indirectly bound thereto.
    Type: Application
    Filed: October 9, 2024
    Publication date: January 23, 2025
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Tie Q. Wei, Zhu Teng, Xiaodong Liu, Martin Drinan
  • Publication number: 20240426814
    Abstract: Methods and reagents are disclosed for minimizing a false result in an assay measurement for determining a concentration of an analyte in a sample suspected of containing the analyte. The method comprises pretreating both an antibody and a sample to be subjected to a non-agglutination immunoassay. In the method the antibody and the sample are combined with a pretreatment agent selected from the group consisting of hydroxyphenyl-substituted C1-C5 carboxylic acids and metallic salts thereof and halogen-substituted C1-C5 carboxylic acids and metallic salts thereof in an amount effective to enhance the accuracy of the non-agglutination immunoassay.
    Type: Application
    Filed: September 6, 2024
    Publication date: December 26, 2024
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Tie Q. Wei, Christy Schaible
  • Patent number: 12140596
    Abstract: Kits containing a chemiluminescent detection system and microfluidics devices and methods for determining the concentration of biotin in a sample are disclosed. The kits, microfluidics devices, and methods utilize a sensitizer capable of generating singlet oxygen in its excited state and having avidin or an analog thereof directly or indirectly bound thereto, as well as a singlet oxygen-activatable chemiluminescent compound having biotin or an analog thereof directly or indirectly bound thereto.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: November 12, 2024
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Tie Q Wei, Zhu Teng, Xiaodong Liu, Martin Drinan
  • Patent number: 12111310
    Abstract: Methods and reagents are disclosed for minimizing a false result in an assay measurement for determining a concentration of an analyte in a sample suspected of containing the analyte. The method comprises pretreating both an antibody and a sample to be subjected to a non-agglutination immunoassay. In the method the antibody and the sample are combined with a pretreatment agent selected from the group consisting of hydroxyphenyl-substituted C1-C5 carboxylic acids and metallic salts thereof and halogen-substituted C1-C5 carboxylic acids and metallic salts thereof in an amount effective to enhance the accuracy of the non-agglutination immunoassay.
    Type: Grant
    Filed: January 24, 2023
    Date of Patent: October 8, 2024
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Tie Q Wei, Christy Schaible
  • Publication number: 20230160880
    Abstract: Methods and reagents are disclosed for minimizing a false result in an assay measurement for determining a concentration of an analyte in a sample suspected of containing the analyte. The method comprises pretreating both an antibody and a sample to be subjected to a non-agglutination immunoassay. In the method the antibody and the sample are combined with a pretreatment agent selected from the group consisting of hydroxyphenyl-substituted C1-C5 carboxylic acids and metallic salts thereof and halogen-substituted C1-C5 carboxylic acids and metallic salts thereof in an amount effective to enhance the accuracy of the non-agglutination immunoassay.
    Type: Application
    Filed: January 24, 2023
    Publication date: May 25, 2023
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Tie Q. Wei, Christy Schaible
  • Patent number: 11592439
    Abstract: Methods and reagents are disclosed for minimizing a false result in an assay measurement for determining a concentration of an analyte in a sample suspected of containing the analyte. The method comprises pretreating both an antibody and a sample to be subjected to a non-agglutination immunoassay. In the method the antibody and the sample are combined with a pretreatment agent selected from the group consisting of hydroxyphenyl-substituted C1-C5 carboxylic acids and metallic salts thereof and halogen-substituted C1-C5 carboxylic acids and metallic salts thereof in an amount effective to enhance the accuracy of the non-agglutination immunoassay.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: February 28, 2023
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Tie Q. Wei, Christy Schaible
  • Patent number: 11377483
    Abstract: Methods are disclosed of designing antibodies for a sandwich assay for a small molecule having a molecular weight of about 500 to about 2,000. The method comprises preparing a first antibody that binds to the small molecule, and preparing a second antibody that binds to the small molecule at a portion of the small molecule other than a portion to which the first antibody binds. The second antibody is prepared from an immunogen that comprises a predetermined portion of the small molecule. The antibodies may be employed in sandwich assays for the small molecule.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: July 5, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Yi Feng Zheng, Tie Q. Wei, Manoj Sharma
  • Publication number: 20210247398
    Abstract: Kits containing a chemiluminescent detection system and microfluidics devices and methods for determining the concentration of biotin in a sample are disclosed. The kits, microfluidics devices, and methods utilize a sensitizer capable of generating singlet oxygen in its excited state and having avidin or an analog thereof directly or indirectly bound thereto, as well as a singlet oxygen-activatable chemiluminescent compound having biotin or an analog thereof directly or indirectly bound thereto.
    Type: Application
    Filed: July 24, 2019
    Publication date: August 12, 2021
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Tie Q. Wei, Zhu Teng, Xiaodong Liu, Martin Drinan
  • Publication number: 20210087255
    Abstract: Methods are disclosed of designing antibodies for a sandwich assay for a small molecule having a molecular weight of about 500 to about 2,000. The method comprises preparing a first antibody that binds to the small molecule, and preparing a second antibody that binds to the small molecule at a portion of the small molecule other than a portion to which the first antibody binds. The second antibody is prepared from an immunogen that comprises a predetermined portion of the small molecule. The antibodies may be employed in sandwich assays for the small molecule.
    Type: Application
    Filed: December 4, 2020
    Publication date: March 25, 2021
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Yi Feng Zheng, Tie Q. Wei, Manoj Sharma
  • Publication number: 20200217839
    Abstract: Methods and reagents are disclosed for minimizing a false result in an assay measurement for determining a concentration of an analyte in a sample suspected of containing the analyte. The method comprises pretreating both an antibody and a sample to be subjected to a non-agglutination immunoassay. In the method the antibody and the sample are combined with a pretreatment agent selected from the group consisting of hydroxyphenyl-substituted C1-C5 carboxylic acids and metallic salts thereof and halogen-substituted C1-C5 carboxylic acids and metallic salts thereof in an amount effective to enhance the accuracy of the non-agglutination immunoassay.
    Type: Application
    Filed: March 19, 2020
    Publication date: July 9, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Tie Q. Wei, Christy Schaible
  • Publication number: 20190128877
    Abstract: Methods and reagents are disclosed for minimizing a false result in an assay measurement for determining a concentration of an analyte in a sample suspected of containing the analyte. The method comprises pretreating both an antibody and a sample to be subjected to a non-agglutination immunoassay. In the method the antibody and the sample are combined with a pretreatment agent selected from the group consisting of hydroxyphenyl-substituted C1-C5 carboxylic acids and metallic salts thereof and halogen-substituted C1-C5 carboxylic acids and metallic salts thereof in an amount effective to enhance the accuracy of the non-agglutination immunoassay.
    Type: Application
    Filed: December 19, 2018
    Publication date: May 2, 2019
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Tie Q. Wei, Christy Schaible
  • Patent number: 10191069
    Abstract: Methods are disclosed for determining an actual concentration of a hydrophobic haptenic analyte in an unknown sample suspected of containing the hydrophobic haptenic analyte, wherein the unknown sample is suspected of containing an interfering substance. A first assay method is conducted on an unknown sample to obtain a measured concentration of the hydrophobic haptenic analyte in the unknown sample. A second assay method is conducted on the unknown sample to obtain a concentration of the interfering substance in the unknown sample. A predetermined correction formula that utilizes the measured concentration of the hydrophobic haptenic analyte and the measured concentration of the interfering substance obtained in step (a) is applied to determine an actual concentration of the hydrophobic haptenic analyte in the unknown sample.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: January 29, 2019
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Izak Bahar, Tie Q. Wei
  • Publication number: 20170362305
    Abstract: Methods are disclosed of designing antibodies for a sandwich assay for a small molecule having a molecular weight of about 500 to about 2,000. The method comprises preparing a first antibody that binds to the small molecule, and preparing a second antibody that binds to the small molecule at a portion of the small molecule other than a portion to which the first antibody binds. The second antibody is prepared from an immunogen that comprises a predetermined portion of the small molecule. The antibodies may be employed in sandwich assays for the small molecule.
    Type: Application
    Filed: December 11, 2015
    Publication date: December 21, 2017
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Yi Feng Zheng, Tie Q. Wei, Manoj Sharma
  • Publication number: 20170356922
    Abstract: Methods are disclosed for determining an actual concentration of a hydrophobic haptenic analyte in an unknown sample suspected of containing the hydrophobic haptenic analyte, wherein the unknown sample is suspected of containing an interfering substance. A first assay method is conducted on an unknown sample to obtain a measured concentration of the hydrophobic haptenic analyte in the unknown sample. A second assay method is conducted on the unknown sample to obtain a concentration of the interfering substance in the unknown sample. A predetermined correction formula that utilizes the measured concentration of the hydrophobic haptenic analyte and the measured concentration of the interfering substance obtained in step (a) is applied to determine an actual concentration of the hydrophobic haptenic analyte in the unknown sample.
    Type: Application
    Filed: December 11, 2015
    Publication date: December 14, 2017
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Izak Bahar, Tie Q. Wei
  • Publication number: 20170160295
    Abstract: Methods include determining in a sample an amount of a first isomeric analyte and a second isomeric analyte. A first measurement value and a second measurement value are determined. The first measurement value represents a total amount of the first isomeric analyte and the second isomeric analyte. The second measurement value represents an amount of the second isomeric analyte only. The second measurement value is subtracted from the first measurement value to obtain a resulting value and the resulting value is equated to an amount of the first isomeric analyte in the sample.
    Type: Application
    Filed: February 23, 2017
    Publication date: June 8, 2017
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Tie Q. Wei, Izak Bahar
  • Patent number: 9618523
    Abstract: Methods include determining in a sample an amount of a first isomeric analyte and a second isomeric analyte. A first measurement value and a second measurement value are determined. The first measurement value represents a total amount of the first isomeric analyte and the second isomeric analyte. The second measurement value represents an amount of the second isomeric analyte only. The second measurement value is subtracted from the first measurement value to obtain a resulting value and the resulting value is equated to an amount of the first isomeric analyte in the sample.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: April 11, 2017
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Tie Q. Wei, Izak Bahar
  • Publication number: 20160313310
    Abstract: Methods and reagents are disclosed for minimizing a false result in an assay measurement for determining a concentration of an analyte in a sample suspected of containing the analyte. The method comprises pretreating both an antibody and a sample to be subjected to a non-agglutination immunoassay. In the method the antibody and the sample are combined with a pretreatment agent selected from the group consisting of hydroxyphenyl-substituted C1-C5 carboxylic acids and metallic salts thereof and halogen-substituted C1-C5 carboxylic acids and metallic salts thereof in an amount effective to enhance the accuracy of the non-agglutination immunoassay.
    Type: Application
    Filed: December 10, 2014
    Publication date: October 27, 2016
    Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.
    Inventors: Tie Q. Wei, Christy Schaible
  • Patent number: 9121859
    Abstract: Compositions are disclosed for releasing an FKBP-binding immunosuppressant drug from endogenous binding substances in a sample suspected of containing the FKBP-binding immunosuppressant drug. The compositions include sirolimus derivatives that are modified with a bulky organic radical in the triene portion of the sirolimus molecule. The compositions may be employed in conjunction with assays for an FKBP-binding immunosuppressant drug in a sample suspected of containing the drug.
    Type: Grant
    Filed: December 4, 2012
    Date of Patent: September 1, 2015
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Yi Feng Zheng, Tie Q. Wei
  • Publication number: 20140308751
    Abstract: Methods include adjusting a contribution of one of two analyte homologs to an amount of signal obtained in an assay for determining a total amount of the two analyte homologs in a sample. A non-assay receptor is employed that has a greater binding affinity for whichever of the two analyte homologs whose contribution to the amount of signal is to be adjusted. An amount of the non-assay receptor is sufficient to achieve an adjustment of the contribution of the analyte homolog to the signal. The assay for determining the total amount of the two analyte homologs is conducted where the assay utilizes at least one assay antibody.
    Type: Application
    Filed: April 12, 2013
    Publication date: October 16, 2014
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Tie Q. Wei, William Bedzyk, Elsa Garcia
  • Publication number: 20140242615
    Abstract: Methods include determining in a sample an amount of a first isomeric analyte and a second isomeric analyte. A first measurement value and a second measurement value are determined. The first measurement value represents a total amount of the first isomeric analyte and the second isomeric analyte. The second measurement value represents an amount of the second isomeric analyte only. The second measurement value is subtracted from the first measurement value to obtain a resulting value and the resulting value is equated to an amount of the first isomeric analyte in the sample.
    Type: Application
    Filed: February 28, 2013
    Publication date: August 28, 2014
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Tie Q. Wei, Izak Bahar