Patents by Inventor Tiehua Ni

Tiehua Ni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In vitro packaging of adeno-associated virus DNA
    Patent number: 5741683
    Abstract: A method for in vitro packaging of adeno-associated viral particles is described. The procedure involves the preparation of cell-free extracts containing all the essential components for packaging. Homogeneous purified substrate DNA for packaging may be prepared separately. The in vitro packaged AAV particles are useful in transduction of mammalian cells and for gene therapy in animals. In one described method, the DNA packaged into AAV particles is not limited by the size constraints characteristic of in vivo packaged AAV particles.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 21, 1998
    Assignee: The Research Foundation of State University of New York
    Inventors: Xiaohuai Zhou, Nicholas Muzyczka, Sergei Zolotukhin, Tiehua Ni
  • In vitro packaging of adeno-associated virus DNA
    Patent number: 5688676
    Abstract: A method for in vitro packaging of adeno-associated viral particles is described. The procedure involves the preparation of cell-free extracts containing all the essential components for packaging. Homogeneous purified substrate DNA for packaging may be prepared separately. The in vitro packaged AAV particles are useful in transduction of mammalian cells and for gene therapy in animals. In one described method, the DNA packaged into AAV particles is not limited by the size constraints characteristic of in vivo packaged AAV particles.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 18, 1997
    Assignee: Research Foundation of State University of New York
    Inventors: Xiaohuai Zhou, Nicholas Muzyczka, Sergei Zolotukhin, Tiehua Ni
  • In vitro packaging of adeno-associated virus DNA
    Patent number: 5688675
    Abstract: A method for in vitro packaging of adeno-associated viral particles is described. The procedure involves the preparation of cell-free extracts containing all the essential components for packaging. Homogeneous purified substrate DNA for packaging may be prepared separately. The in vitro packaged AAV particles are useful in transduction of mammalian cells and for gene therapy in animals. In one described method, the DNA packaged into AAV particles is not limited by the size constraints characteristic of in vivo packaged AAV particles.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 18, 1997
    Assignee: Research Foundation of State University of New York
    Inventors: Xiaohuai Zhou, Nicholas Muzyczka, Sergei Zolotukhin, Tiehua Ni
  • In vitro packaging of adeno-associated virus DNA
    Patent number: 5677158
    Abstract: A method for in vitro packaging of adeno-associated vital particles is described. The procedure involves the preparation of cell-free extracts containing all the essential components for packaging. Homogeneous purified substrate DNA for packaging may be prepared separately. The in vitro packaged AAV particles are useful in transduction of mammalian cells and for gene therapy in animals. In one described method, the DNA packaged into AAV particles is not limited by the size constraints characteristic of in vivo packaged AAV particles.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 14, 1997
    Assignee: Research Foundation of State University of New York
    Inventors: Xiaohuai Zhou, Nicholas Muzyczka, Sergei Zolotukhin, Tiehua Ni