Abstract: A device and method for monitoring freezing-thawing damage of an underwater concrete member in situ. A main structure includes an upper link, concrete member, transverse sealed box, longitudinal sealed box, movable guide rod, probe launching box, multichannel data collector, frequency modulation transmitter, computer, auxiliary wheels, lower link, and a wireless temperature sensor. A process includes four steps: launching of a probe, collection of data, calculation of an elastic modulus, and evaluation of freezing-thawing damage.

Abstract: The present application discloses a milk warmer, which includes: a milk warmer base, the milk warmer base is provided with a first accommodation space, and the first accommodation space is used to accommodate milk to be heated; a heating member for heating the first accommodation space; a temperature measuring member for detecting the temperature of the heating member; a first fixing bracket used to fix the position of the temperature measuring member; wherein the heating member is provided with a connection hole, one end of the temperature measuring member is connected in the connection hole, and the other end of the temperature measuring member is connected with the first fixing bracket. The milk warmer of this disclosure can increase the volume of the heating member while maintaining an original volume of the milk warmer, and the heating speed can be increased accordingly.

Abstract: The present application relates to milk powder packaging field. The present application provides a powder dispensing apparatus for dispensing fixed amount of powder, including a powder outputting member, a bottle mouth connecting assembly and a plurality of resetting members, the powder outputting member has a powder outlet, the bottle mouth connecting assembly includes a valve and a bottle mouth connecting member, the bottle mouth connecting member has a sliding groove, each the resetting member is located in the sliding groove, one end of each resetting member is connected to the bottom of the sliding groove, the other end is connected to the powder outputting member, the valve and the powder outlet are detachably connected, a side of the bottle mouth connecting member deviating from the valve is connected to the powder storing bottle. The present application improves the accuracy of fixed amount of powder dispensing.

Abstract: The present invention provides feed additive to promote the growth of sows and piglets, which comprises serine, astragalus and ginseng leaves. The feed additive preferably contains: 50-60 wt % of the serine, 20-25 wt % of the astragalus, 20-25 wt % of the ginseng leaves and the balance of rice bran meal as a carrier. The invention also provides applications of the above-mentioned feed additive in promoting the growth of sows and piglets, that is, before feeding, make the serine content in the diet reach 0.69 wt % and incorporate it into the diet of gestational sows, and/or make the serine content in the diet reach 0.82 wt % and incorporate it into the diet of lactating sows.

Abstract: Microparticle formulations of a sialidase fusion protein are produced by contacting an aqueous solution of a protein or other active agent with an organic solvent, a counterion and a scavenging agent, and chilling the solution. The microparticles are useful for preparing stable, uniform pharmaceuticals of predetermined defined dimensions.

Abstract: A method of reducing or treating parainfluenza or influenza virus infection in an immunocompromised patient by administering to the respiratory tract of the patient a composition comprising a therapeutically effective amount of protein having sialidase activity.

Abstract: A marine monitoring buoy with an improved structure belongs to the technical field of marine buoys. The marine monitoring buoy includes a first buoy body, a cylindrical portion and a conical portion. A vertical through hole is disposed in the first buoy body, a horizontal through hole is disposed in an upper part of the cylindrical portion, an upper end of the vertical through hole extends to the cylindrical portion and is in communication with the horizontal through hole, a lower end of the vertical through hole penetrates through the conical portion, a wind power generator is disposed in the vertical through hole, two guiding grooves are disposed on a side wall of a lower part of the vertical through hole, a metal piston rod is disposed in the vertical through hole.

Abstract: A marine monitoring buoy with an improved structure belongs to the technical field of marine buoys. The marine monitoring buoy includes a first buoy body, a cylindrical portion and a conical portion. A vertical through hole is disposed in the first buoy body, a horizontal through hole is disposed in an upper part of the cylindrical portion, an upper end of the vertical through hole extends to the cylindrical portion and is in communication with the horizontal through hole, a lower end of the vertical through hole penetrates through the conical portion, a wind power generator is disposed in the vertical through hole, two guiding grooves are disposed on a side wall of a lower part of the vertical through hole, a metal piston rod is disposed in the vertical through hole.

Abstract: Microparticle formulations of a sialidase fusion protein are produced by contacting an aqueous solution of a protein or other active agent with an organic solvent, a counterion and a scavenging agent, and chilling the solution. The microparticles are useful for preparing stable, uniform pharmaceuticals of predetermined defined dimensions.

Abstract: A liposome for delivery of nucleic acid is provided herein, comprising cationic lipid compound, a phospholipid and a PEGylated lipid, wherein the cationic lipid compound is in an amount from 50 wt % to 90 wt % and consist of a lipid compound and a cholesterol lipid compound. A nucleic acid liposome formulation comprising the said liposome and the nucleic acid encapsulated by the liposome and the method for preparing the same are provided therein. Increased amount of nucleic acid can be loaded into the nucleic acid liposome formulation as described therein. Thus, at the same dosage, intake of the cationic lipid compound is decreased, thereby decreasing toxicity.

Abstract: This invention relates to interfering RNA (iRNA) molecules and their applications, especially multi-targets iRNA molecules and their applications. The said multi-targets iRNA molecules comprised of a sense strand annealed onto at least one antisense strand, each strand is at least 30 nucleotides in length, the sense or antisense strand has at least two segments, which can target at least two RNAs of different genes, or can target at least two portions of an RNA, and wherein the iRNA does not induce an interferon-response when transfected into a cell. The iRNA molecule can interfere with the translation procedure post-transcription, and the target gene is inhibited or blocked, the iRNA does not induce an interferon-response in vivo. The RNA molecules are the active ingredient in preparation of the drug which can regulate one or many genes function.

Abstract: Techniques for filtering information are described herein. In accordance with the present disclosure, a text acquisition module is configured to acquire text content to be filtered and a scanning module is configured to scan the text content to be filtered. The disclosed techniques scan the text content through a preset keyword dictionary, record a position of each keyword in the text content and acquire character pitch between keywords in the text content according to the position of each keyword in text content. A pitch judgment module is configured to judge whether the character pitch exceeds a preset character pitch and filter the keyword(s) in the text content in response to a determination that the character pitch exceeds the preset character pitch.

Abstract: The present invention belongs to the field of medicine technology, particularly relating to an application of cyclic dinucleotide (cGAMP) in tumor treatment. Researches carried out in the present invention show that, cGAMP can inhibit growth of many types of tumor cells, with remarkable anti-tumor effect, thus, it can be used in preparation of anti-tumor drugs; and the prepared anti-tumor drugs have low toxicity and favorable effect. Proved by a subcutaneous tumor model in nude mice, cGAMP has a remarkable inhibition effect on tumors of human gastric carcinoma cell line MNK-45, human lung adenocarcinoma cell line A549, human colorectal carcinoma cell line Lovo, human hepatocellular carcinoma cell line SMMC-7721, human prostatic carcinoma cell line PC-3 and human pancreatic carcinoma cell SW1990, which are subcutaneously implanted in nude mice, and also proved by animal acute toxicity experiment. cGAMP has a relatively low acute toxicity, therefore and may be used for preparing anti-tumor drugs.

Abstract: The present invention discloses a liposome formulation, its preparation method, and its application in the treatment of diseases caused by abnormal gene expression. The liposome formulation comprises complementary cationic lipid pairs, phospholipids, and long-circulating lipids. The method of preparing the liposome formulation comprises: mixing the complementary cationic lipid pairs with the phospholipid and the long-circulating lipid to generate pre-formed vesicles; and then mixing the pre-formed vesicles with the nucleic acid solution to generate the liposome-nucleic acid formulation. This liposome formulation provided by the present invention is easily prepared; and in the treatment of diseases caused by abnormal gene expression, the liposome formulation can be used to deliver in vivo therapeutic agents, including nucleic acids.

Abstract: An information transmission apparatus for logging while drilling comprises a hollow drilling rod and at least one cable. The drilling rod comprises at least one first drilling rod member and at least one second drilling rod member spliced to each other alternately. The first drilling rod member comprises a through hole, and the second drilling rod member comprises a stepped hole. The cable comprises a fixed end, a connected end, and a folded portion connect the fixed end to the connected end. Each of the cables is fixed in the stepped hole through a fixed end or is connected to a connected end of an adjacent cable. The connected end may be stretched along the stepped hole, and stretched through the through hole to be electrically connected to a logging instrument or a fixed end of the adjacent cable. The apparatus provides protection for a cable through a hollow drilling rod, thereby improving the transmission reliability.

Abstract: Microparticle formulations of a sialidase fusion protein are produced by contacting an aqueous solution of a protein or other active agent with an organic solvent, a counterion and a scavenging agent, and chilling the solution. The microparticles are useful for preparing stable, uniform pharmaceuticals of predetermined defined dimensions.

Abstract: This invention is directed to a RNA interference (RNAi) agent and the use of that RNAi agent to treat hepatitis B infection in individuals, as well as pharmaceutical compositions containing the RNAi agents of the invention. The RNAi agents, or constructs for expressing them are utilized to inhibit expression of at least one Hepatitis B virus (HBV) gene, where the agent comprises an effector sequence complementary to or substantially complementary to a predicted sequence transcribed from a target region. In some forms of the invention, the agent has more than one effector sequence. Multiple effectors may target the same region of an HBV gene, different (possibly overlapping) regions of the same gene and/or different HBV genes.

Abstract: The present invention belongs to the field of medicine technology, particularly relating to an application of cyclic dinucleotide (cGAMP) in tumor treatment. Researches carried out in the present invention show that, cGAMP can inhibit growth of many types of tumor cells, with remarkable anti-tumor effect, thus, it can be used in preparation of anti-tumor drugs; and the prepared anti-tumor drugs have low toxicity and favorable effect. Proved by a subcutaneous tumor model in nude mice, cGAMP has a remarkable inhibition effect on tumors of human gastric carcinoma cell line MNK-45, human lung adenocarcinoma cell line A549, human colorectal carcinoma cell line Lovo, human hepatocellular carcinoma cell line SMMC-7721, human prostatic carcinoma cell line PC-3 and human pancreatic carcinoma cell SW1990, which are subcutaneously implanted in nude mice, and also proved by animal acute toxicity experiment. cGAMP has a relatively low acute toxicity, therefore and may be used for preparing anti-tumor drugs.

Abstract: Microparticle formulations of a sialidase fusion protein are produced by contacting an aqueous solution of a protein or other active agent with an organic solvent, a counterion and a scavenging agent, and chilling the solution. The microparticles are useful for preparing stable, uniform pharmaceuticals of predetermined defined dimensions.

Abstract: A method of reducing or treating parainfluenza or influenza virus infection in an immunocompromised patient by administering to the respiratory tract of the patient a composition comprising a therapeutically effective amount of protein having sialidase activity.