Patents by Inventor Tiejun Li

Tiejun Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20260109636
    Abstract: The present invention relates to the technical field of livestock and poultry manure treatment, and in particular, to an intelligent manure treatment system based on green ecological breeding of livestock and poultry and a method therefor.
    Type: Application
    Filed: July 16, 2025
    Publication date: April 23, 2026
    Applicants: Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan Normal University
    Inventors: Liuqin He, Jian Wu, Tiejun Li, Wenjie Tang, Yulong Yin, Xihong Zhou, Wenxuan Wu
  • Publication number: 20260022103
    Abstract: A pramipexole xinafoate and a sustained-release pharmaceutical formulation thereof are provided. The pramipexole is prepared into its xinafoate, enabling reducing a solubility of the pramipexole salts. A suspension liquid formulation prepared from the pramipexole xinafoate has a good sustained-release effect and good stability, and is suitable for large-scale production.
    Type: Application
    Filed: March 14, 2023
    Publication date: January 22, 2026
    Inventors: Yingji SUN, Yuguang WANG, Xiaoyan XING, Shankui LIU, Tiejun LI
  • Publication number: 20250387457
    Abstract: A method of reducing or treating parainfluenza or influenza virus infection in an immunocompromised patient by administering to the respiratory tract of the patient a composition comprising a therapeutically effective amount of protein having sialidase activity.
    Type: Application
    Filed: January 21, 2025
    Publication date: December 25, 2025
    Inventors: Ronald D. Moss, Tiejun Li
  • Publication number: 20250330432
    Abstract: A method and system for solving bypass-based modular multi-chiplet deadlock include polling each border router by means of time slice round-robin scheduling inside each chiplet; when processing upon arrival of the time slice of the border router, the border router is polled based on the internal time slice of the chiplet in a switchover manner to trigger the bypass mechanism of choke packets, and an output port is reserved between the border router and the destination router by using a look-ahead signal to build a bypass, and reserving a network interface and a rollback mechanism when the bypass packet pops up. The present disclosure aims at achieving deadlock-free in realizing bypass-based modular multi-chiplet design requirements in a multi-chiplet architecture under 2.5D packaging.
    Type: Application
    Filed: February 25, 2025
    Publication date: October 23, 2025
    Inventors: Tiejun Li, Jianmin Zhang, Yi Dai, Yi Yang, Sheng Ma, Lizhou Wu, Bo Yang
  • Publication number: 20250257345
    Abstract: The present application provides compositions comprising at least four subspecies of DAS181 that can be separated by CEX-HPLC, methods of releasing a DAS181 composition for human medical use, comprising subjecting the composition to CEX-HPLC, and determining the relative amounts of the first, second, third, and fourth and optionally fifth subspecies separated by the CEX-HPLC, formulations for DAS181 or DAS181 multi¬subspecies compositions, and methods of treating a disease comprising administering any of the DAS181 compositions described herein.
    Type: Application
    Filed: November 1, 2022
    Publication date: August 14, 2025
    Inventors: George WANG, Stephen HAWLEY, Tiejun LI
  • Patent number: 12173017
    Abstract: A BMOFs nanosheet based on a ZIF/MIL topology, and a preparation method and an application thereof are provided. The preparation method includes dispersing a MOF material of a ZIFs series in an organic phase, then adding an aqueous phase to obtain a mixture; and adding a MOF material of a MILs series into the mixture, sealing, standing for 1-5 days, filtering, performing centrifugal washing, drying, and performing acetone ultrasonic exfoliation to obtain the BMOFs nanosheet based on the ZIF/MIL topology. The preparation method is simple to operate and moderate in conditions, and the prepared ZIF/MIL BMOFs nanosheet has good electrocatalytic activity and stability in an OER.
    Type: Grant
    Filed: May 3, 2024
    Date of Patent: December 24, 2024
    Assignees: Zhejiang University of Technology, Zhejiang Marine Fisheries Research Institute
    Inventors: Lei Qin, Xiaoyan Mao, Tiejun Li, Yingyu Tan, Wenjie Liu, Lei Jin
  • Publication number: 20240383936
    Abstract: A BMOFs nanosheet based on a ZIF/MIL topology, and a preparation method and an application thereof are provided. The preparation method includes dispersing a MOF material of a ZIFs series in an organic phase, then adding an aqueous phase to obtain a mixture; and adding a MOF material of a MILs series into the mixture, sealing, standing for 1-5 days, filtering, performing centrifugal washing, drying, and performing acetone ultrasonic exfoliation to obtain the BMOFs nanosheet based on the ZIF/MIL topology. The preparation method is simple to operate and moderate in conditions, and the prepared ZIF/MIL BMOFs nanosheet has good electrocatalytic activity and stability in an OER.
    Type: Application
    Filed: May 3, 2024
    Publication date: November 21, 2024
    Inventors: Lei Qin, Xiaoyan Mao, Tiejun Li, Yingyu Tan, Wenjie Liu, Lei Jin
  • Patent number: 12137836
    Abstract: The present application discloses a milk warmer, which includes: a milk warmer base, the milk warmer base is provided with a first accommodation space, and the first accommodation space is used to accommodate milk to be heated; a heating member for heating the first accommodation space; a temperature measuring member for detecting the temperature of the heating member; a first fixing bracket used to fix the position of the temperature measuring member; wherein the heating member is provided with a connection hole, one end of the temperature measuring member is connected in the connection hole, and the other end of the temperature measuring member is connected with the first fixing bracket. The milk warmer of this disclosure can increase the volume of the heating member while maintaining an original volume of the milk warmer, and the heating speed can be increased accordingly.
    Type: Grant
    Filed: May 25, 2023
    Date of Patent: November 12, 2024
    Assignee: SHENZHEN JINGDU TECHNOLOGY CO., LTD.
    Inventors: Shaoyuan Xu, Tiejun Li, Huchun Xiao
  • Publication number: 20240188210
    Abstract: A printed circuit board and an apparatus including the printed circuit board are described. The printed circuit board includes a plurality of layers; a footprint fabricated on an outer layer of the plurality of layers; a plurality of signal pins and a ground pin, wherein the plurality of signal pins and the ground pin are included in the footprint. The printed circuit board includes a ground guard including: ground pads, ground layers, and a set of vias. The vias are located on the ground pads and connect the ground layers. The vias are located between the ground pin and at least one signal pin of the plurality of signal pins in a direction parallel to a plane of the plurality of layers. A quantity of the vias is based on satisfying a signal integrity threshold associated with the at least one signal pin of the plurality of signal pins.
    Type: Application
    Filed: December 5, 2023
    Publication date: June 6, 2024
    Applicant: NIO Technology (Anhui) Co., Ltd.
    Inventors: Tiejun Li, Jianfeng Xu, Futing Lin
  • Publication number: 20240049908
    Abstract: The present application discloses a milk warmer, which includes: a milk warmer base, the milk warmer base is provided with a first accommodation space, and the first accommodation space is used to accommodate milk to be heated; a heating member for heating the first accommodation space; a temperature measuring member for detecting the temperature of the heating member; a first fixing bracket used to fix the position of the temperature measuring member; wherein the heating member is provided with a connection hole, one end of the temperature measuring member is connected in the connection hole, and the other end of the temperature measuring member is connected with the first fixing bracket. The milk warmer of this disclosure can increase the volume of the heating member while maintaining an original volume of the milk warmer, and the heating speed can be increased accordingly.
    Type: Application
    Filed: May 25, 2023
    Publication date: February 15, 2024
    Inventors: SHAOYUAN XU, TIEJUN LI, HUCHUN XIAO
  • Patent number: 11708200
    Abstract: The present application relates to milk powder packaging field. The present application provides a powder dispensing apparatus for dispensing fixed amount of powder, including a powder outputting member, a bottle mouth connecting assembly and a plurality of resetting members, the powder outputting member has a powder outlet, the bottle mouth connecting assembly includes a valve and a bottle mouth connecting member, the bottle mouth connecting member has a sliding groove, each the resetting member is located in the sliding groove, one end of each resetting member is connected to the bottom of the sliding groove, the other end is connected to the powder outputting member, the valve and the powder outlet are detachably connected, a side of the bottle mouth connecting member deviating from the valve is connected to the powder storing bottle. The present application improves the accuracy of fixed amount of powder dispensing.
    Type: Grant
    Filed: January 13, 2023
    Date of Patent: July 25, 2023
    Assignee: SHENZHEN JINGDU TECHNOLOGY CO., LTD.
    Inventors: Shaoyuan Xu, Tiejun Li, Huchun Xiao
  • Publication number: 20210386096
    Abstract: The present invention provides feed additive to promote the growth of sows and piglets, which comprises serine, astragalus and ginseng leaves. The feed additive preferably contains: 50-60 wt % of the serine, 20-25 wt % of the astragalus, 20-25 wt % of the ginseng leaves and the balance of rice bran meal as a carrier. The invention also provides applications of the above-mentioned feed additive in promoting the growth of sows and piglets, that is, before feeding, make the serine content in the diet reach 0.69 wt % and incorporate it into the diet of gestational sows, and/or make the serine content in the diet reach 0.82 wt % and incorporate it into the diet of lactating sows.
    Type: Application
    Filed: June 14, 2021
    Publication date: December 16, 2021
    Inventors: LIUQIN HE, TIEJUN LI, YANZHONG FENG, WENJIE TANG, YULONG YIN, JIANZHONG LI, SHENGPING WANG, XINGGUO HE
  • Publication number: 20210353719
    Abstract: Microparticle formulations of a sialidase fusion protein are produced by contacting an aqueous solution of a protein or other active agent with an organic solvent, a counterion and a scavenging agent, and chilling the solution. The microparticles are useful for preparing stable, uniform pharmaceuticals of predetermined defined dimensions.
    Type: Application
    Filed: March 23, 2021
    Publication date: November 18, 2021
    Inventors: Michael P. Malakhov, Tiejun Li
  • Publication number: 20210046165
    Abstract: A method of reducing or treating parainfluenza or influenza virus infection in an immunocompromised patient by administering to the respiratory tract of the patient a composition comprising a therapeutically effective amount of protein having sialidase activity.
    Type: Application
    Filed: July 31, 2020
    Publication date: February 18, 2021
    Inventors: Ronald B Moss, Tiejun Li
  • Patent number: 10850810
    Abstract: A marine monitoring buoy with an improved structure belongs to the technical field of marine buoys. The marine monitoring buoy includes a first buoy body, a cylindrical portion and a conical portion. A vertical through hole is disposed in the first buoy body, a horizontal through hole is disposed in an upper part of the cylindrical portion, an upper end of the vertical through hole extends to the cylindrical portion and is in communication with the horizontal through hole, a lower end of the vertical through hole penetrates through the conical portion, a wind power generator is disposed in the vertical through hole, two guiding grooves are disposed on a side wall of a lower part of the vertical through hole, a metal piston rod is disposed in the vertical through hole.
    Type: Grant
    Filed: November 28, 2019
    Date of Patent: December 1, 2020
    Inventors: Huiwen Cai, Tiejun Li, Yonghua Ren
  • Publication number: 20200172203
    Abstract: A marine monitoring buoy with an improved structure belongs to the technical field of marine buoys. The marine monitoring buoy includes a first buoy body, a cylindrical portion and a conical portion. A vertical through hole is disposed in the first buoy body, a horizontal through hole is disposed in an upper part of the cylindrical portion, an upper end of the vertical through hole extends to the cylindrical portion and is in communication with the horizontal through hole, a lower end of the vertical through hole penetrates through the conical portion, a wind power generator is disposed in the vertical through hole, two guiding grooves are disposed on a side wall of a lower part of the vertical through hole, a metal piston rod is disposed in the vertical through hole.
    Type: Application
    Filed: November 28, 2019
    Publication date: June 4, 2020
    Inventors: Huiwen CAI, Tiejun LI, Yonghua REN
  • Publication number: 20200164048
    Abstract: Microparticle formulations of a sialidase fusion protein are produced by contacting an aqueous solution of a protein or other active agent with an organic solvent, a counterion and a scavenging agent, and chilling the solution. The microparticles are useful for preparing stable, uniform pharmaceuticals of predetermined defined dimensions.
    Type: Application
    Filed: July 8, 2019
    Publication date: May 28, 2020
    Inventors: Michael P Malakhov, Tiejun Li
  • Publication number: 20190380963
    Abstract: A liposome for delivery of nucleic acid is provided herein, comprising cationic lipid compound, a phospholipid and a PEGylated lipid, wherein the cationic lipid compound is in an amount from 50 wt % to 90 wt % and consist of a lipid compound and a cholesterol lipid compound. A nucleic acid liposome formulation comprising the said liposome and the nucleic acid encapsulated by the liposome and the method for preparing the same are provided therein. Increased amount of nucleic acid can be loaded into the nucleic acid liposome formulation as described therein. Thus, at the same dosage, intake of the cationic lipid compound is decreased, thereby decreasing toxicity.
    Type: Application
    Filed: April 8, 2017
    Publication date: December 19, 2019
    Inventors: Jianxin CHEN, Wei PENG, Tiejun LI, Yan NI, Wenjian FENG
  • Patent number: 10443057
    Abstract: This invention relates to interfering RNA (iRNA) molecules and their applications, especially multi-targets iRNA molecules and their applications. The said multi-targets iRNA molecules comprised of a sense strand annealed onto at least one antisense strand, each strand is at least 30 nucleotides in length, the sense or antisense strand has at least two segments, which can target at least two RNAs of different genes, or can target at least two portions of an RNA, and wherein the iRNA does not induce an interferon-response when transfected into a cell. The iRNA molecule can interfere with the translation procedure post-transcription, and the target gene is inhibited or blocked, the iRNA does not induce an interferon-response in vivo. The RNA molecules are the active ingredient in preparation of the drug which can regulate one or many genes function.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: October 15, 2019
    Assignee: Biomics Biotechnologies, Co., Ltd.
    Inventors: York Yuan Yuan Zhu, Tiejun Li
  • Patent number: D1074317
    Type: Grant
    Filed: October 26, 2022
    Date of Patent: May 13, 2025
    Assignee: SHENZHEN JINGDU TECHNOLOGY CO., LTD.
    Inventors: Shaoyuan Xu, Tiejun Li, Huchun Xiao