Patents by Inventor Tien Huynh
Tien Huynh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230073821Abstract: Techniques regarding antigen-binding proteins that can bind to CoV (e.g., SARS-CoV-2) variants are provided. For example, one or more embodiments described herein can comprise an antigen-binding protein that can comprise a heavy polypeptide chain variable region with an amino acid sequence that is a variant of SEQ ID NO: 7. The amino acid sequence can comprise at least one amino acid substitution selected from the group consisting of: R50D, R50E, R50W, R50F, R50Y, R50L, R50V, R50I, R50Pho, I54D, I54E, I54W, I54F, I54Y, I54Pho, L55D, L55E, L55W, L55F, L55Y, and L55Pho.Type: ApplicationFiled: August 27, 2021Publication date: March 9, 2023Inventors: Binquan Luan, Leili Zhang, Tien Huynh
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Publication number: 20200147558Abstract: A membrane for the capture of carbon dioxide is provided. The membrane includes a polymeric porous hollow fiber substrate and a coating disposed on a surface of the polymeric porous hollow fiber substrate, where the coating comprises graphene oxide and an amine. A method of forming a coated polymeric hollow fiber support for the capture of carbon dioxide is also provided. The method includes dispersing graphene oxide in a coating solution comprising a solvent; dispersing an amine in the coating solution; and exposing a polymeric hollow fiber support to the coating solution to form a coating on a surface of the polymeric hollow fiber support, wherein the coated polymeric hollow fiber support has a carbon dioxide/nitrogen selectivity ranging from about 200 to about 2000 and a carbon dioxide permeance ranging from about 100 gas permeation units to about 1000 gas permeation units.Type: ApplicationFiled: March 29, 2018Publication date: May 14, 2020Inventors: MIAO YU, FANGLEI ZHOU, NGOC TIEN HUYNH, SHIGUANG LI
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Patent number: 8912317Abstract: Sequences of ribonucleic acid interference molecules are provided. For example, in one aspect, at least one nucleic acid molecule comprising at least one of one or more precursor sequences having SEQ_ID NO: 1 through SEQ_ID NO: 3,197 and one or more corresponding mature sequences having SEQ_ID NO: 3,198 through SEQ_ID NO: 6,565 is provided. Techniques are also provided for regulating gene expression.Type: GrantFiled: July 31, 2008Date of Patent: December 16, 2014Assignee: International Business Machines CorporationInventors: Tien Huynh, Isidore Rigoutsos
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Patent number: 8795987Abstract: Sequences of ribonucleic acid interference molecules are provided. For example, in one aspect, at least one nucleic acid molecule comprising at least one of one or more precursor sequences having SEQ_ID NO: 1 through SEQ_ID NO: 11,928 and one or more corresponding mature sequences having SEQ_ID NO: 11,929 through SEQ_ID NO: 24,555 is provided. Techniques are also provided for regulating gene expression.Type: GrantFiled: July 31, 2008Date of Patent: August 5, 2014Assignee: International Business Machines CorporationInventors: Tien Huynh, Isidore Rigoutsos
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Patent number: 8494784Abstract: A method for determining whether a nucleotide sequence contains a microRNA binding site and which microRNA will bind thereto is provided. For example, in one aspect of the invention, a method for determining whether a nucleotide sequence contains a microRNA binding site and which microRNA sequence will bind thereto is comprised of the following steps. One or more patterns are generated by processing a collection of known mature microRNA sequences. The reverse complement of each generated patter is then computed. One or more attributes are then assigned to the reverse complement of the one or more generated patterns. The one or more patterns that correspond to a reverse complement having one or more assigned attributes that satisfy at least one criterion are thereafter subselected. Each subselected pattern is then used to analyze the nucleotide sequence, such that a determination is made whether the nucleotide sequence contains a microRNA binding site and which microRNA sequence will bind thereto.Type: GrantFiled: June 9, 2008Date of Patent: July 23, 2013Assignee: International Business Machines CorporationInventors: Tien Huynh, Kevin Charles Miranda, Isidore Rigoutsos
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Patent number: 8445666Abstract: Ribonucleic acid interference molecules are provided. In one aspect of the invention, a method for regulating gene expression comprises the following step. At least one nucleic acid molecule comprising at least one of one or more precursor sequences having SEQ ID NO: 1 through SEQ ID NO: 103,948, each one of the precursor sequences containing one or more mature sequences having SEQ ID NO: 103,949 through SEQ ID NO: 230,447, is used to regulate the expression of one or more genes.Type: GrantFiled: October 27, 2011Date of Patent: May 21, 2013Assignee: International Business Machines CorporationInventors: Isidore Rigoutsos, Tien Huynh, Kevin Charles Miranda
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Patent number: 8189931Abstract: A method and system are disclosed for matching input character sequences in a set of input patterns. The method comprises the steps of analyzing the set of input patterns, creating a pattern cluster look-up table (PCLT) based on said input patterns, and defining an offset value k. The PCLT is used to find, for each sequence s and offset k, a set of candidate patterns that can possibly match s, the set of candidate patterns is searched for patterns that match s, and all found matching patterns and sequences are reported.Type: GrantFiled: January 4, 2008Date of Patent: May 29, 2012Assignee: International Business Machines CorporationInventors: Tien Huynh, Stanislav Polonsky, Isidore Rigoutsos
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Patent number: 8178503Abstract: In one aspect of the invention, a method for regulating the expression of a transcript comprises using at least one interfering RNA molecule that binds to an area of transcript containing a region that corresponds to at least one sequence having SEQ ID NO: 1, the interfering RNA molecule regulating the expression of the transcript through post-transcriptional silencing. In another aspect, a method for regulating the expression of a transcript comprises at least one of the provided sequences having SEQ ID NO: 1 being used to design an interfering RNA molecule that contains a region that corresponds to the reverse complement of one or more sequences having SEQ ID NO: 1, the interfering molecule regulating, through post-transcriptional silencing, transcripts that contain the sequence having SEQ ID NO: 1.Type: GrantFiled: April 21, 2006Date of Patent: May 15, 2012Assignee: International Business Machines CorporationInventors: Isidore Rigoutsos, Tien Huynh, Aristotelis Tsirigos, Alice Carolyn McHardy
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Publication number: 20120040460Abstract: Ribonucleic acid interference molecules are provided. In one aspect of the invention, a method for regulating gene expression comprises the following step. At least one nucleic acid molecule comprising at least one of one or more precursor sequences having SEQ ID NO: 1 through SEQ ID NO: 103,948, each one of the precursor sequences containing one or more mature sequences having SEQ ID NO: 103,949 through SEQ ID NO: 230,447, is used to regulate the expression of one or more genes.Type: ApplicationFiled: October 27, 2011Publication date: February 16, 2012Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Isidore Rigoutsos, Tien Huynh, Kevin Charles Miranda
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Patent number: 8065091Abstract: Techniques for linking non-coding and gene coding regions of a genome are provided. In one aspect, a method of determining associations between non-coding sequences and gene coding sequences in a genome of an organism comprises the following steps. At least one conserved region is identified from one or more non-coding sequences. Additional instances of the conserved region are located in the untranslated or amino acid coding regions of one or more genes in the organism under consideration, and the conserved region is associated with the one or more biological processes in which these one or more genes participate.Type: GrantFiled: October 30, 2007Date of Patent: November 22, 2011Assignee: International Business Machines CorporationInventors: Isidore Rigoutsos, Tien Huynh, Aristotelis Tsirigos, Alice Carolyn McHardy, Kevin Charles Miranda
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Publication number: 20110178283Abstract: Sequences that can be used in the context of controlled gene regulation are provided. In one aspect, at least one sequence comprising at least one of one or more sequences having SEQ ID NO: 1 through SEQ ID NO: 747,326 is provided. One or more of the provided sequences may be computationally predicted, e.g., from publicly available genomes, using a method based on pattern discovery. In another aspect, a method for regulating the expression of a transcript comprises the step of said transcript containing a region that corresponds to at least one of the provided sequences having SEQ ID NO: 1 through SEQ ID NO: 747,326, the region being targeted either by a naturally occurring, or appropriately designed, interfering RNA molecule that regulates the expression of said transcript through post-transcriptional silencing.Type: ApplicationFiled: April 21, 2006Publication date: July 21, 2011Applicant: International Business Machines CorporationInventors: Isidore Rigoutsos, Tien Huynh, Aristotelis Tsirigos, Alice Carolyn McHardy
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Publication number: 20090175520Abstract: Disclose are a method of and system for matching input character sequences in a set of input patterns. The method comprises the steps of analyzing the set of input patterns, creating a pattern cluster look-up table (PCLT) based on said input patterns, and defining an offset value k. The PCLT is used to find, for each sequence s and offset k, a set of candidate patterns that can possibly match s, the set of candidate patterns is searched for patterns that match s, and all found matching patterns and sequences are reported.Type: ApplicationFiled: January 4, 2008Publication date: July 9, 2009Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Tien Huynh, Stanislav Polonsky, Isidore Rigoutsos
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Publication number: 20090093624Abstract: Techniques for linking non-coding and gene coding regions of a genome are provided. In one aspect, a method of determining associations between non-coding sequences and gene coding sequences in a genome of an organism comprises the following steps. At least one conserved region is identified from one or more non-coding sequences. Additional instances of the conserved region are located in the untranslated or amino acid coding regions of one or more genes in the organism under consideration, and the conserved region is associated with the one or more biological processes in which these one or more genes participate.Type: ApplicationFiled: October 30, 2007Publication date: April 9, 2009Applicant: International Business Machines CorporationInventors: Isidore Rigoutsos, Tien Huynh, Aristotelis Tsirigos, Alice Carolyn McHardy, Kevin Charles Miranda
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Publication number: 20090012720Abstract: A method for determining whether a nucleotide sequence contains a microRNA binding site and which microRNA will bind thereto is provided. For example, in one aspect of the invention, a method for determining whether a nucleotide sequence contains a microRNA binding site and which microRNA sequence will bind thereto is comprised of the following steps. One or more patterns are generated by processing a collection of known mature microRNA sequences. The reverse complement of each generated patter is then computed. One or more attributes are then assigned to the reverse complement of the one or more generated patterns. The one or more patterns that correspond to a reverse complement having one or more assigned attributes that satisfy at least one criterion are thereafter subselected. Each subselected pattern is then used to analyze the nucleotide sequence, such that a determination is made whether the nucleotide sequence contains a microRNA binding site and which microRNA sequence will bind thereto.Type: ApplicationFiled: June 9, 2008Publication date: January 8, 2009Applicant: International Business Machines CorporationInventors: Tien Huynh, Kevin Charles Miranda, Isidore Rigoutsos
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Publication number: 20080311661Abstract: Sequences of ribonucleic acid interference molecules are provided. For example, in one aspect, at least one nucleic acid molecule comprising at least one of one or more precursor sequences having SEQ_ID NO: 1 through SEQ_ID NO: 3,197 and one or more corresponding mature sequences having SEQ_ID NO: 3,198 through SEQ_ID NO: 6,565 is provided. Techniques are also provided for regulating gene expression.Type: ApplicationFiled: July 31, 2008Publication date: December 18, 2008Applicant: International Business Machines CorporationInventors: Tien Huynh, Isidore Rigoutsos
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Publication number: 20080311659Abstract: Sequences of ribonucleic acid interference molecules are provided. For example, in one aspect, at least one nucleic acid molecule comprising at least one of one or more precursor sequences having SEQ_ID NO: 1 through SEQ_ID NO: 11,928 and one or more corresponding mature sequences having SEQ_ID NO: 11,929 through SEQ_ID NO: 24,555 is provided. Techniques are also provided for regulating gene expression.Type: ApplicationFiled: July 31, 2008Publication date: December 18, 2008Applicant: International Business Machines CorporationInventors: Tien Huynh, Isidore Rigoutsos
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Publication number: 20080125583Abstract: Ribonucleic acid interference molecules are provided. For example, in one aspect of the invention, at least one nucleic acid molecule comprising at least one of one or more precursor sequences having SEQ ID NO: 1 through SEQ ID NO: 103,948 and one or more mature sequences having SEQ ID NO: 1 through SEQ ID NO: 126,499 is provided. One or more of the at least one of one or more precursor sequences and one or more mature sequences may be computationally predicted, e.g., from publicly available genomes, using a pattern discovery method. In another aspect of the invention, a method for regulating gene expression comprises the following step. At least one nucleic acid molecule comprising at least one of one or more precursor sequences having SEQ ID NO: 1 through SEQ ID NO: 103,948, each one of the precursor sequences containing one or more mature sequences having SEQ ID NO: 1 through SEQ ID NO: 126,499, is used to regulate the expression of one or more genes, e.g.Type: ApplicationFiled: February 10, 2006Publication date: May 29, 2008Applicant: International Business Machines CorporationInventors: Isidore Rigoutsos, Tien Huynh, Kevin Charles Miranda
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Publication number: 20080052008Abstract: Techniques for linking non-coding and gene coding regions of a genome are provided. In one aspect, a method of determining associations between non-coding sequences and gene coding sequences in a genome of an organism comprises the following steps. At least one conserved region is identified from one or more non-coding sequences. Additional instances of the conserved region are located in the untranslated or amino acid coding regions of one or more genes in the organism under consideration, and the conserved region is associated with the one or more biological processes in which these one or more genes participate.Type: ApplicationFiled: October 30, 2007Publication date: February 28, 2008Applicant: International Business Machines CorporationInventors: Isidore Rigoutsos, Tien Huynh, Aristotelis Tsirigos, Alice McHardy, Kevin Miranda
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Publication number: 20070154896Abstract: A method for determining whether a nucleotide sequence contains a microRNA binding site and which microRNA will bind thereto is provided. For example, in one aspect of the invention, a method for determining whether a nucleotide sequence contains a microRNA binding site and which microRNA sequence will bind thereto is comprised of the following steps. One or more patterns are generated by processing a collection of known mature microRNA sequences. The reverse complement of each generated patter is then computed. One or more attributes are then assigned to the reverse complement of the one or more generated patterns. The one or more patterns that correspond to a reverse complement having one or more assigned attributes that satisfy at least one criterion are thereafter subselected. Each subselected pattern is then used to analyze the nucleotide sequence, such that a determination is made whether the nucleotide sequence contains a microRNA binding site and which microRNA sequence will bind thereto.Type: ApplicationFiled: February 10, 2006Publication date: July 5, 2007Applicant: International Business Machines CorporationInventors: Tien Huynh, Kevin Miranda, Isidore Rigoutsos
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Publication number: 20070042397Abstract: Techniques for linking non-coding and gene coding regions of a genome are provided. In one aspect, a method of determining associations between non-coding sequences and gene coding sequences in a genome of an organism comprises the following steps. At least one conserved region is identified from one or more non-coding sequences. Additional instances of the conserved region are located in the untranslated or amino acid coding regions of one or more genes in the organism under consideration, and the conserved region is associated with the one or more biological processes in which these one or more genes participate.Type: ApplicationFiled: March 3, 2006Publication date: February 22, 2007Applicant: International Business Machines CorporationInventors: Isidore Rigoutsos, Tien Huynh, Aristotelis Tsirigos, Alice McHardy, Kevin Miranda