Abstract: Aspects of the invention include an optimal interpretable decision tree using integer linear programming techniques. A non-limiting example computer-implemented method includes receiving, using a processor, a plurality of data inputs from a process and selecting, using the processor, a data subset from the plurality of data inputs by solving linear programming to obtain a solution. The method builds and optimizes, using the processor, an optimal decision tree based on the data subset and alerts, using the processor, a user when a prediction of the optimal decision tree is greater than a threshold value.

Abstract: Improved sub-assemblies and methods of control for use in a diagnostic assay system adapted to receive an assay cartridge are provided herein. Such sub-assemblies include: a brushless DC motor, a door opening/closing mechanism and cartridge loading mechanism, a syringe and valve drive mechanism assembly, a sonication horn, a thermal control device and optical detection/excitation device. Such systems can further include a communications unit configured to wirelessly communicate with a mobile device of a user so as to receive a user input relating to functionality of the system with respect to an assay cartridge received therein and relaying a diagnostic result relating to the assay cartridge to the mobile device.

Abstract: Aspects of the invention include implemented method includes selecting an optimization algorithm for the control system of a processing plant based on whether the control system is guided by a linear-based predictive model or a non-linear-based predictive model, in which a gradient is available. Calculating set-point variables using the optimization algorithm. Predicting an output based on the calculated set-point variables. Comparing an actual output at the processing plant to the predicted output. Suspending a physical process at the processing plant in response to the actual output being a threshold value apart from the predicted output.

Abstract: Embodiments are provided for generating a reasonable language model learning for text data in a knowledge graph in a computing system by a processor. One or more data sources and one or more triples may be analyzed from a knowledge graph. Training data having one or more candidate labels associated with one or more of the triples may be generated. One or more reasonable language models may be trained based on the training data.

Abstract: A computer implemented method of generating a classifier engine for machine learning includes receiving a set of data points. A semi-supervised k-means process is applied to the set of data points from each class. The set of data points in a class is clustered into multiple clusters of data points, using the semi-supervised k-means process. Multi-polytopes are constructed for one or more of the clusters from all classes. A support vector machine (SVM) process is run on every pair of clusters from all classes. Separation hyperplanes are determined for the clustered classes. Labels are determined for each cluster based on the separation by hyperplanes.

Abstract: A computer-implemented method for a shuffling-type gradient for training a machine learning model using a stochastic gradient descent (SGD) includes the operations of uniformly randomly distributing data samples or coordinate updates of a training data, and calculating the learning rates for a no-shuffling scheme and a shuffling scheme. A combined operation of the no-shuffling scheme and the shuffling scheme of the training data is performed using a stochastic gradient descent (SGD) algorithm. The combined operation is switched to performing only the shuffling scheme from the no-shuffling scheme based on one or more predetermined criterion; and training the machine learning models with the training data based on the combined no-shuffling scheme and shuffling scheme.

Abstract: Improved sub-assemblies and methods of control for use in a diagnostic assay system adapted to receive an assay cartridge are provided herein. Such sub-assemblies include: a brushless DC motor, a door opening/closing mechanism and cartridge loading mechanism, a syringe and valve drive mechanism assembly, a sonication horn, a thermal control device and optical detection/excitation device. Such systems can further include a communications unit configured to wirelessly communicate with a mobile device of a user so as to receive a user input relating to functionality of the system with respect to an assay cartridge received therein and relaying a diagnostic result relating to the assay cartridge to the mobile device.

Abstract: A computer-implemented method, a computer program product, and a computer system for stochastic event triage. A computer receives an event log including timestamps and event types. The computer determines a sparse impact matrix representing causal relationships between the event types, via a cardinality regularization. The computer determines triggering probabilities representing causal association probabilities between individual event instances, by leveraging a variational bound of a likelihood function. The computer provides a user with the triggering probabilities for event triage. The computer learns model parameters by iterating type-level causal analysis and instance-level causal analysis.

Abstract: A computer-implemented method for site-wide prediction optimization includes training a plurality of a mixed type of regression models with a mixed type of control variables for identifying control set-points of a site-wide operation. A decision tree regression model is trained to predict a status of the plurality of initial set-points for non-linear regression functions. The decision tree regression model is reformulated into a mixed-integer linear program (MILP) and solved by an MILP solver to find a global solution. An MILP surrogate is determined for a nonlinear optimization problem to provide a best solution for one or more of the non-linear regression functions using the best solution as a starting point for solving non-linear regression functions, and a set-point of the mixed control variables is recommended to control a throughput of the site-wide operation by executing a decomposition operation or a federated learning algorithm.

Abstract: A computer-implemented method for a shuffling-type gradient for training a machine learning model using a stochastic gradient descent (SGD) includes the operations of uniformly randomly distributing data samples or coordinate updates of a training data, and calculating the learning rates for a no-shuffling scheme and a shuffling scheme. A combined operation of the no-shuffling scheme and the shuffling scheme of the training data is performed using a stochastic gradient descent (SGD) algorithm. The combined operation is switched to performing only the shuffling scheme from the no-shuffling scheme based on one or more predetermined criterion; and training the machine learning models with the training data based on the combined no-shuffling scheme and shuffling scheme.

Abstract: Aspects of the invention include implemented method includes selecting an optimization algorithm for the control system of a processing plant based on whether the control system is guided by a linear-based predictive model or a non-linear-based predictive model, in which a gradient is available. Calculating set-point variables using the optimization algorithm. Predicting an output based on the calculated set-point variables. Comparing an actual output at the processing plant to the predicted output. Suspending a physical process at the processing plant in response to the actual output being a threshold value apart from the predicted output.

Abstract: Aspects of the invention include training an optimal interpretable decision tree for regression using mixed-integer linear programming techniques. A non-limiting example computer-implemented method includes receiving, using a processor, input data that includes time-series data. The method further includes training, using a binary mixed-integer linear program of the processor, an ODT for regression based on the input data. During the training process one or more outliers are filtered out by a linear loss model that minimizes training loss and outlier loss.

Abstract: A computer-implemented method for maintaining equipment in a geo-distributed system includes receiving, by a processor, a selection of quantities to optimize when adjusting a maintenance schedule of the geo-distributed system that includes multiple pieces of equipment that are spread over a geographical region, and wherein the maintenance schedule identifies when a set of maintenance tasks are executed at a first equipment from the geo-distributed system over a predetermined duration. The method further includes generating, by the processor, a mixed-integer linear program for optimizing the maintenance schedule using a set of predetermined constraints. The method further includes executing, by the processor, the mixed-integer linear program via a mixed-integer linear program solver. The method further includes adjusting, by the processor, the maintenance schedule by selecting only a subset of the maintenance tasks.

Abstract: In an approach to hyperparameter optimization, one or more computer processors express a hyperparameter tuning process of a model based on a type of model, one or more dimensions of a training dataset, associated loss function of the model, and associated computational constraints of the model, comprising: identifying a set of optimal hyper-rectangles based a calculated local variability and a calculated best function value; calculating a point as a representative for each identified potentially optimal hyper-rectangle by locally searching over the identified set of potentially optimal hyper-rectangles; dividing one or more hyper-rectangles in the identified set of optimal hyper-rectangles into a plurality of smaller hyper-rectangles based on each calculated point; and calculating one or more optimal hyperparameters utilizing a globally converged hyper-rectangle from the plurality of smaller hyper-rectangles.

Abstract: A computer implemented method for automatically generating an optimization model for site-wide plant optimization includes mapping a process flow diagram of a plant process to a graph comprising nodes and edges, wherein the nodes represent processes and the edges represent flows between processes. A behavior is learned for each node of the graph based at least on historic data of the plant process. One or more regression functions are modeled for each node to predict an output of each of the processes, wherein the one or more regression functions are modeled based on the learned behavior for each node.

Abstract: Techniques for model evaluation and selection are provided. A plurality of models trained to generate predictions at each of a plurality of intervals is received, and a plurality of model ensembles, each specifying one or more of the plurality of models for each of the plurality of intervals, is generated. A test data set is received, where the test data set includes values for at least a first interval of the plurality of intervals and does not include values for at least a second interval of the plurality of intervals. A first model ensemble, of the plurality of model ensembles, is selected based on processing the test data set using each of the plurality of model ensembles.

Abstract: Techniques for generating model ensembles are provided. A plurality of models trained to generate predictions at each of a plurality of intervals is received. A respective prediction accuracy of each respective model of the plurality of models is determined for a first interval of the plurality of intervals by processing labeled evaluation data using the respective model. Additionally, a model ensemble specifying one or more of the plurality of models for each of the plurality of intervals is generated, comprising selecting, for the first interval, a first model of the plurality of models based on (i) the respective prediction accuracies and (ii) at least one non-error metric.

Abstract: Thermal control devices adapted to provide improved control and efficiency in temperature cycling are provided herein. Such thermal control device can include a thermoelectric cooler controlled in coordination with another thermal manipulation device to control an opposing face of the thermoelectric cooler and/or a microenvironment. Some such thermal control devices include a first and second thermoelectric cooler separated by a thermal capacitor. The thermal control devices can be configured in a planar configuration with a means for thermally coupling with a planar reaction vessel of a sample analyzer for use in thermal cycling in a polymerase chain reaction of the fluid sample in the reaction vessel. Methods of thermal cycling using such a thermal control devices are also provided.

Abstract: A DC electric motor having a stator mounted to a substrate, the stator having a coil assembly having a magnetic core, a rotor mounted to the stator with permanent magnets distributed radially about the rotor, the permanent magnets extending beyond the magnetic core, and sensors mounted to the substrate adjacent the permanent magnets. During operation of the motor passage of the permanent magnets over the sensors produces a substantially sinusoidal signal of varying voltage substantially without noise and/or saturation, allowing an angular position of the rotor relative the substrate to be determined from linear portions of the sinusoidal signal without requiring use of an encoder or position sensors and without requiring noise-reduction or filtering of the signal.

Abstract: Aspects of the invention include an optimal interpretable decision tree using integer linear programming techniques. A non-limiting example computer-implemented method includes receiving, using a processor, a plurality of data inputs from a process and selecting, using the processor, a data subset from the plurality of data inputs by solving linear programming to obtain a solution. The method builds and optimizes, using the processor, an optimal decision tree based on the data subset and alerts, using the processor, a user when a prediction of the optimal decision tree is greater than a threshold value.