Patents by Inventor Tieu-Binh Le

Tieu-Binh Le has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS
    Publication number: 20220396588
    Abstract: Compounds of the formulas which are useful as colony stimulating factor-1 receptor inhibitors (“CSF-1R inhibitors”).
    Type: Application
    Filed: February 9, 2022
    Publication date: December 15, 2022
    Applicant: Genzyme Corporation
    Inventors: John L. Kane, JR., Claude Barberis, Mark Czekaj, Paul Erdman, Barret Giese, Michael Kothe, Tieu-Binh Le, Jinyu Liu, Liang Ma, Markus Metz, Vinod Patel, Andrew Scholte, Patrick Shum, Linli Wei
  • Colony stimulating factor-1 receptor (CSF-1R) inhibitors
    Patent number: 11274108
    Abstract: Compounds of the formulas which are useful as colony stimulating factor-1 receptor inhibitors (“CSF-1R inhibitors”).
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: March 15, 2022
    Assignee: GENZYME CORPORATION
    Inventors: John L. Kane, Jr., Claude Barberis, Mark Czekaj, Paul Erdman, Barret Giese, Michael Kothe, Tieu-Binh Le, Jinyu Liu, Liang Ma, Markus Metz, Vinod Patel, Andrew Scholte, Patrick Wai-Kwok Shum, Linli Wei
  • COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS
    Publication number: 20190016707
    Abstract: Compounds of the formulas which are useful as colony stimulating factor-1 receptor inhibitors (“CSF-1R inhibitors”).
    Type: Application
    Filed: July 19, 2016
    Publication date: January 17, 2019
    Inventors: John L. KANE, Jr., Claude Barberis, Mark Czekaj, Paul Erdman, Barret Giese, Michael Kothe, Tieu-Binh Le, Jinyu Liu, Liang Ma, Markus Metz, Vinod Patel, Andrew Scholte, Patrick Wai-Kwok Shum, Linli Wei
  • Substituted benzoylamino-indan-2-carboxylic acids and related compounds
    Patent number: 8569535
    Abstract: The present invention relates to novel compounds of the formula Ia: in any of its stereoisomeric forms or a mixture of stereoisomeric forms in any ratio, or a physiologically acceptable salt thereof, wherein the substituents are as described herein. The inventive compounds have CXCR5 inhibitory activity, and are particularly useful in treating or preventing various inflammatory diseases, such as rheumatoid arthritis, multiple sclerosis, lupus, Crohn's Disease, associated with the modulation of the human CXCR5 receptor.
    Type: Grant
    Filed: November 30, 2009
    Date of Patent: October 29, 2013
    Assignee: Sanofi
    Inventors: Thomas Joseph Caulfield, Jennifer Williford Clemens, Robert S. Francis, Brian Scott Freed, Stanly John, Tieu-Binh Le, Brian Pedgrift, Antonio Daniel Ramos, Gerard Charles Rosse, Martin Smrcina, David Squire Thorpe, William Shelly Wire, Jianhong Zhao
  • SUBSTITUTED BENZOYLAMINO-INDAN-2-CARBOXYLIC ACIDS AND RELATED COMPOUNDS
    Publication number: 20100113462
    Abstract: The present invention relates to novel compounds of the formula I: wherein in any of its stereoisomeric forms or a mixture of stereoisomeric forms in any ratio, or a physiologically acceptable salt thereof, wherein the substituents are as described herein. The inventive compounds have CXCR5 inhibitory activity are particularly useful in treating or preventing various inflammatory diseases, such as rheumatoid arthritis, multiple sclerosis, lupus, Crohn's Disease, associated with the modulation of the human CXCR5 receptor.
    Type: Application
    Filed: November 30, 2009
    Publication date: May 6, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Thomas J. CAULFIELD, Jennifer Williford CLEMENS, Robert S. FRANCIS, Brian S. FREED, Stanly JOHN, Tieu-Binh LE, Brian PEDGRIFT, Antonio D. RAMOS, Gerard Charles ROSSE, Martin SMRCINA, David S. THORPE, William WIRE, Jianhong ZHAO
  • Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
    Patent number: 6423704
    Abstract: The present invention relates to novel 4-(1H-benzimidazol-2-yl)[1,4]diazepane derivatives of formula (1): and stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: July 23, 2002
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: George D. Maynard, Tieu-Binh Le
  • Novel substituted 4-(1H-benzimidazol-2-yl) [1,4]diazepanes useful for the treatment of allergic diseases
    Publication number: 20010034343
    Abstract: The present invention relates to novel 4-(1H-benzimidazol-2-yl)[1,4]diazepane derivatives of formula 1
    Type: Application
    Filed: December 18, 2000
    Publication date: October 25, 2001
    Inventors: George D. Maynard, Tieu-Binh Le
  • Heterocyclic substituted piperazinone derivatives
    Patent number: 5864045
    Abstract: The present invention relates to substituted piperazinone derivatives of formula (1) or stereoisomers, or pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, cough, and bronchitis. The present invention also relates to intermediates useful in the preparation of compounds of formula (1).
    Type: Grant
    Filed: April 27, 1998
    Date of Patent: January 26, 1999
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Timothy P. Burkholder, Elizabeth M. Kudlacz, Tieu-Binh Le
  • Substituted pyrrolidin-3-yl-alkyl-piperidines
    Patent number: 5861416
    Abstract: The present invention relates to substituted pyrrolidinyl-3-yl-alkyl-piperidines, their stereoisomers, and pharmaceutically acceptable salts thereof and processes for preparation of the same. The compounds of the present invention are useful in their pharmacological activities such as tachykinin antagonism, especially substance P and neurokinin A antagonism, and the like. Compounds having the property of tachykinin antagonism are indicated for conditions associated with neurogenic inflammation and other diseases described herein.
    Type: Grant
    Filed: February 6, 1997
    Date of Patent: January 19, 1999
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Timothy P. Burkholder, Tieu-Binh Le, Elizabeth M. Kudlacz, George D. Maynard
  • Heterocyclic substituted piperazinone derivatives
    Patent number: 5840726
    Abstract: The present invention relates to substituted piperazinone derivatives (compounds of formula (1)) or stereoisomers, or pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, cough, and bronchitis. The present invention also relates to intermediates useful in the preparation of compounds of formula (1).
    Type: Grant
    Filed: June 19, 1997
    Date of Patent: November 24, 1998
    Assignee: Hoechst Marion Roussel Inc.
    Inventors: Timothy P. Burkholder, Elizabeth M. Kudlacz, Tieu-Binh Le
  • Substituted piperazine derivatives
    Patent number: 5672602
    Abstract: The present invention relates to substituted piperazine derivatives (herein referred to as compounds or compounds of formula (1)) or stereoisomers, or pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, cough, and bronchitis.
    Type: Grant
    Filed: April 30, 1996
    Date of Patent: September 30, 1997
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Timothy P. Burkholder, Tieu-Binh Le, Elizabeth M. Kudlacz
  • Substituted pyrrolidin-3-yl-alkyl-piperidines
    Patent number: 5661160
    Abstract: The present invention relates to substituted pyrrolidinyl-3-yl-alkyl-piperidines, their stereoisomers, and pharmaceutically acceptable salts thereof and processes for preparation of the same. The compounds of the present invention are useful in their pharmacological activities such as tachykinin antagonism, especially substance P and neurokinin A antagonism, and the like. Compounds having the property of tachykinin antagonism are indicated for conditions associated with neurogenic inflammation and other diseases described herein.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 26, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Timothy P. Burkholder, Tieu-Binh Le, Elizabeth M. Kudlacz, George D. Maynard
  • Substituted pyrrolidin-3-yl-alkyl-piperidines
    Patent number: 5648366
    Abstract: The present invention relates to substituted pyrrolidinyl-3-yl-alkyl-piperidines, their stereoisomers, and pharmaceutically acceptable salts thereof and processes for preparation of the same. The compounds of the present invention are useful in their pharmacological activities such as tachykinin antagonism, especially substance P and neurokinin A antagonism, and the like. Compounds having the property of tachykinin antagonism are indicated for conditions associated with neurogenic inflammation and other diseases described herein.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 15, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Timothy P. Burkholder, Tieu-Binh Le, Elizabeth M. Kudlacz, George D. Maynard
  • Substituted alkyldiamine derivatives
    Patent number: 5597845
    Abstract: The present invention relates to novel substituted alkyldiamine derivatives and pharmaceutically acceptable salts thereof which are useful tachykinin antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions including asthma, cough, and bronchitis.
    Type: Grant
    Filed: June 20, 1994
    Date of Patent: January 28, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Timothy P. Burkholder, Elizabeth M. Kudlacz, Tieu-Binh Le