Patents by Inventor Tiiu Kullisaaar

Tiiu Kullisaaar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Strain of micro-organism as novel anti-microbiol and anti-oxidative probiotic
    Patent number: 7244424
    Abstract: The strain of micro-organism Lactobacillus fermentum ME-3 is a novel anti-microbial and anti-oxidative probiotic. It has a high anti-microbial effect on Escherichia coli, Shigella sonnei, Staphylococcus aureus, Salmonella typhimurium, and moderate activity against Helicobacter pylori strains. The strain of micro-organism possesses Mn-superoxide dismutase and both its lysates and intact cells have high anti-oxidative activity, increasing the glutathione red-ox ratio in blood sera and able to capture toxic hydroxyl radicals. The strain of micro-organism could be used as a probiotic for the production of functional food (yoghurt, cheese) and non-comestibles (tablets, capsules) for the prophylaxis of intestinal and uroinfections, both for the prevention and treatment of chronic diseases, caused by prolonged oxidative stress.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: July 17, 2007
    Assignee: University of Tartu
    Inventors: Marika Mikelsaar, Mihkel Zilmer, Tiiu Kullisaaar, Heidi Annuk, Epp Songisepp
  • Strain of micro-organism lactobacillus fermentum me-3 as novel anti-microbial and anti-oxidative probiotic
    Publication number: 20040151708
    Abstract: The strain of micro-organism Lactobacillus fermentum ME-3 is a novel anti-microbial and anti-oxidative probiotic. It has a high anti-microbial effect on Escherichia coli, Shigella sonnei, Staphylococcus aureus, Salmonella typhimurium, and moderate activity against Helicobacter pylori strains. The strain of micro-organism possesses Mn-superoxide dismutase and both its lysates and intact cells have high anti-oxidative activity, increasing the glutathione red-ox ratio in blood sera and able to capture toxic hydroxyl radicals. The strain of micro-organism could be used as a probiotic for the production of functional food (yoghurt, cheese) and non-comestibles (tablets, capsules) for the prophylaxis of intestinal and uroinfections, both for the prevention and treatment of chronic diseases, caused by prolonged oxidative stress.
    Type: Application
    Filed: December 22, 2003
    Publication date: August 5, 2004
    Inventors: Marika Mikelsaar, Mikhel Zilmer, Tiiu Kullisaaar, Heidi Annuk, Epp Songisepp