Patents by Inventor Tilman Laeppchen

Tilman Laeppchen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Agents for clearing biomolecules from circulation
    Patent number: 9427482
    Abstract: Described is a method, and a combination of agents for used therein, by which an agent administered to a subject can be rapidly cleared from circulation. This is achieved by providing an Administration Agent (e.g. a probe for pretargeting) with a reactive group and providing a Clearing Agent with another reactive group, said reactive groups forming a bio-orthogonally reactive pair. Preferably, the reactive pair comprises a cyclooctene or cyclooctyn as one reactant, and a diene as the other reactant. The method and combination can be used for the removal of any bindable molecule from circulation, such as an excess of a pre-targeting probe in the course of a pre-targeting method, a targeting or imaging agent delivered, or the removal of any biomolecule already present in circulation.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: August 30, 2016
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Raffaella Rossin, Tilman Laeppchen, Sandra Martina Van Den Bosch, Marc Stefan Robillard, Ronny Mathieu Versteegen
  • AGENTS FOR CLEARING BIOMOLECULES FROM CIRCULATION
    Publication number: 20130272959
    Abstract: Described is a method, and a combination of agents for used therein, by which an agent administered to a subject can be rapidly cleared from circulation. This is achieved by providing an Administration Agent (e.g. a probe for pretargeting) with a reactive group and providing a Clearing Agent with another reactive group, said reactive groups forming a bio-orthogonally reactive pair. Preferably, the reactive pair comprises a cyclooctene or cyclooctyn as one reactant, and a diene as the other reactant. The method and combination can be used for the removal of any bindable molecule from circulation, such as an excess of a pre-targeting probe in the course of a pre-targeting method, a targeting or imaging agent delivered, or the removal of any biomolecule already present in circulation.
    Type: Application
    Filed: December 16, 2011
    Publication date: October 17, 2013
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Raffaella Rossin, Tilman Laeppchen, Sandra Martina Van Den Bosch, Marc Stefan Robillard, Ronny Mathieu Versteegen