Patents by Inventor Tilman Oltersdorf

Tilman Oltersdorf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of Decreasing Ubiquitylated Protein Levels
    Publication number: 20100298348
    Abstract: The present invention provides a method of decreasing the level of ubiquitylated protein in a subject, the method comprising administering a heterocyclic compound disclosed herein or a pharmaceutically acceptable salt, hydrate or prodrug thereof to a subject in need thereof.
    Type: Application
    Filed: May 11, 2010
    Publication date: November 25, 2010
    Inventors: Kim Nicholas Green, Eckard Weber, Tilman Oltersdorf, Sharon Rogers, Frank LaFerla
  • Method of Inducing Cleavage of Amyloid Precursor Protein to Form a Novel Fragment
    Publication number: 20100168135
    Abstract: The present invention provides a method of inducing cleavage of amyloid precursor protein to produce an approximately 17 kilodalton carboxy-terminal fragment of amyloid precursor protein in a subject, the method comprising administering a heterocyclic compound or a pharmaceutically acceptable salt, hydrate or prodrug thereof to a subject in need thereof, wherein the approximately 17 kilodalton fragment includes the carboxyterminal amino acid sequence of amyloid precursor protein and amyloid-beta amino acid sequence. Also provided is a screening method for identifying compounds induce cleavage of amyloid precursor protein to produce the approximately 17 kilodalton carboxy-terminal fragment of amyloid precursor protein.
    Type: Application
    Filed: December 15, 2009
    Publication date: July 1, 2010
    Inventors: Kim Nicholas Green, Tilman Oltersdorf, Eckard Weber
  • Corticotropin-releasing factor receptors
    Patent number: 7034118
    Abstract: The present invention provides isolated nucleic acid molecules encoding CRF2 receptors, recombinant expression vectors and host cells suitable for expressing such receptors, as well as compositions and methods which utilize such receptors.
    Type: Grant
    Filed: April 9, 2004
    Date of Patent: April 25, 2006
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Timothy W Lovenberg, Tilman Oltersdorf, Chen Wang Liaw, Dimitri E Grigoriadis, Derek T Chalmers, Errol B DeSouza
  • Human bad polypeptides, encoding nucleic acids and methods of use
    Patent number: 6824991
    Abstract: The invention provides an isolated gene and an isolated nucleic acid sequence encoding human Bad and functional fragments thereof. Also provided is an isolated human Bad polypeptide and functional fragments thereof. Methods of identifying human Bad binding partners and methods of screening for compounds which interfere with the association of human Bad interacting polypeptides with human Bad are also provided. Finally, methods for decreasing or increasing the viability of a cell are provided as well.
    Type: Grant
    Filed: August 3, 2001
    Date of Patent: November 30, 2004
    Assignee: IDUN Pharmaceuticals Inc.
    Inventors: William A. Horne, Tilman Oltersdorf
  • Corticotropin-releasing factor2 receptors
    Publication number: 20040185533
    Abstract: The present invention provides isolated nucleic acid molecules encoding CRF2 receptors, recombinant expression vectors and host cells suitable for expressing such receptors, as well as compositions and methods which utilize such receptors.
    Type: Application
    Filed: April 9, 2004
    Publication date: September 23, 2004
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Timothy W. Lovenberg, Tilman Oltersdorf, Chen Wang Liaw, Dimitri E. Grigoriadis, Derek T. Chalmers, Errol B. DeSouza
  • Corticotropin-releasing factor2 receptors
    Patent number: 6723841
    Abstract: The present invention provides isolated nucleic acid molecules encoding CRF2 receptors, recombinant expression vectors and host cells suitable for expressing such receptors, as well as compositions and methods which utilize such receptors.
    Type: Grant
    Filed: June 13, 2001
    Date of Patent: April 20, 2004
    Assignee: Neurocrine Biosciences Inc.
    Inventors: Timothy W. Lovenberg, Tilman Oltersdorf, Chen Wang Liaw, Dimitri E. Grigoriadis, Derek T. Chalmers, Errol B. DeSouza
  • Human bad polypeptides, encoding nucleic acids and methods of use
    Patent number: 6504022
    Abstract: The invention provides an isolated gene and an isolated nucleic acid sequence encoding human Bad and functional fragments thereof. Also provided is an isolated human Bad polypeptide and functional fragments thereof. Methods of identifying human Bad binding partners and methods of screening for compounds which interfere with the association of human Bad interacting polypeptides with human Bad are also provided. Finally, methods for decreasing or increasing the viability of a cell are provided as well.
    Type: Grant
    Filed: August 16, 1999
    Date of Patent: January 7, 2003
    Assignee: IDUN Pharmaceuticals, Inc.
    Inventors: William A. Horne, Tilman Oltersdorf
  • Human bad polypeptides, encoding nucleic acids and methods of use
    Publication number: 20020115631
    Abstract: The invention provides an isolated gene and an isolated nucleic acid sequence encoding human Bad and functional fragments thereof. Also provided is an isolated human Bad polypeptide and functional fragments thereof. Methods of identifying human Bad binding partners and methods of screening for compounds which interfere with the association of human Bad interacting polypeptides with human Bad are also provided. Finally, methods for decreasing or increasing the viability of a cell are provided as well.
    Type: Application
    Filed: February 1, 2002
    Publication date: August 22, 2002
    Applicant: Idun Pharamceuticals, Inc.
    Inventors: William A. Horne, Tilman Oltersdorf
  • Corticotropin-releasing factor2 receptors
    Publication number: 20020077468
    Abstract: The present invention provides isolated nucleic acid molecules encoding CRF2 receptors, recombinant expression vectors and host cells suitable for expressing such receptors, as well as compositions and methods which utilize such receptors.
    Type: Application
    Filed: June 13, 2001
    Publication date: June 20, 2002
    Inventors: Timothy W. Lovenberg, Tilman Oltersdorf, Chen Wang Liaw, Dimitri E. Grigoriadis, Derek T. Chalmers, Errol B. DeSouza
  • Human bad polypeptides, encoding nucleic acids and methods of use
    Publication number: 20020037869
    Abstract: The invention provides an isolated gene and an isolated nucleic acid sequence encoding human Bad and functional fragments thereof. Also provided is an isolated human Bad polypeptide and functional fragments thereof. Methods of identifying human Bad binding partners and methods of screening for compounds which interfere with the association of human Bad interacting polypeptides with human Bad are also provided. Finally, methods for decreasing or increasing the viability of a cell are provided as well.
    Type: Application
    Filed: August 3, 2001
    Publication date: March 28, 2002
    Inventors: William A. Horne, Tilman Oltersdorf
  • Interleukin-1 type 3 receptors
    Patent number: 6239268
    Abstract: The present invention provides isolated nucleic acid molecules encoding soluble and membrane bound forms of Interleukin-1 Type 3 receptors, as well as recombinant expression vectors and host cells suitable for expressing such receptors.
    Type: Grant
    Filed: January 8, 1999
    Date of Patent: May 29, 2001
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Timothy W. Lovenberg, Tilman Oltersdorf, Chen Wang Liaw, William R. Clevenger, Errol B. DeSouza
  • Human bad polypeptides, encoding nucleic acids and methods of use
    Patent number: 5965703
    Abstract: The invention provides an isolated gene and an isolated nucleic acid sequence encoding human Bad and functional fragments thereof. Also provided is an isolated human Bad polypeptide and functional fragments thereof. Methods of identifying human Bad binding partners and methods of screening for compounds which interfere with the association of human Bad interacting polypeptides with human Bad are also provided. Finally, methods for decreasing or increasing the viability of a cell are provided as well.
    Type: Grant
    Filed: September 20, 1996
    Date of Patent: October 12, 1999
    Assignee: IDUN Pharmaceuticals
    Inventors: William A. Horne, Tilman Oltersdorf
  • Isolated nucleic acid encoding corticotropin-releasing factor.sub.2 receptors
    Patent number: 5786203
    Abstract: The present invention provides isolated nucleic acid molecules encoding CRF.sub.2 receptors, recombinant expression vectors and host cells suitable for expressing such receptors, as well as compositions and methods which utilize such receptors.
    Type: Grant
    Filed: January 31, 1995
    Date of Patent: July 28, 1998
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Timothy W. Lovenberg, Tilman Oltersdorf, Chen Wang Liaw, Dimitri E. Grigoriadis, Errol DeSouza