Patents by Inventor Tilman Plass

Tilman Plass has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MULTIPLE CYCLOADDITION REACTIONS FOR LABELING OF MOLECULES
    Publication number: 20200231539
    Abstract: The present invention relates to methods for linking tetrazines with dienophiles to establish at least two linkages by sequentially performing at least two cycloaddition reactions. The methods in particular allow establishing multi-labeling strategies. In particular, the invention relates to methods for forming linkages by cycloaddition reactions, wherein the method comprises reacting a first alkyl-substituted tetrazine with a first dienophile comprising a irans-cyclooctenyl group followed by reacting a second tetrazine with a second dienophile comprising a cyclooctynyl group, wherein the reaction of the first tetrazine with the first dienophile proceeds in the presence of the second dienophile.
    Type: Application
    Filed: November 22, 2019
    Publication date: July 23, 2020
    Applicant: EUROPEAN MOLECULAR BIOLOGY LABORATORY
    Inventors: Edward Lemke, Carsten Schultz, Tilman Plass, Ivana Nikic, Jan-Erik Hoffmann, Iker Valle Aramburu
  • Trans-cyclooctene amino and hydroxy acids and their use in multiple cycloaddition reactions for labeling of molecules
    Patent number: 10519101
    Abstract: The present invention relates to compounds of formula: and methods for linking tetrazines with dienophiles to establish at least two linkages by sequentially performing at least two cycloaddition reactions. The methods in particular allow establishing multi-labeling strategies. In particular, the invention relates to methods for forming linkages by cycloaddition reactions, wherein the method comprises reacting a first alkyl-substituted tetrazine with a first dienophile comprising a trans-cyclooctenyl group followed by reacting a second tetrazine with a second dienophile comprising a cyclooctynyl group, wherein the reaction of the first tetrazine with the first dienophile proceeds in the presence of the second dienophile.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: December 31, 2019
    Assignee: European Molecular Biology Laboratory
    Inventors: Edward Lemke, Carsten Schultz, Tilman Plass, Ivana Nikic, Jan-Erik Hoffmann, Iker Valle Aramburu
  • Unnatural amino acids comprising a cyclooctynyl or trans-cyclooctenyl analog group and uses thereof
    Patent number: 9085514
    Abstract: The present invention relates to unnatural amino acids comprising a cyclooctynyl or trans-cyclooctenyl analog group and having formula (I) or an acid or base addition salt thereof. The invention also relates to the use of said unnatural amino acids, kits and processes for preparation of polypeptides that comprise one or more than one cyclooctynyl or trans-cyclooctenyl analog group. These polypeptides can be covalently modified by in vitro or in vivo reaction with compounds comprising an azide, nitrile oxide, nitrone, diazocarbonyl or 1,2,4,5-tetrazine group.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: July 21, 2015
    Assignee: EMBL
    Inventors: Edward Lemke, Carsten Schultz, Tilman Plass, Sigrid Milles, Christine Koehler
  • UNNATURAL AMINO ACIDS COMPRISING A CYCLOOCTYNYL OR TRANS-CYCLOOCTENYL ANALOG GROUP AND USES THEREOF
    Publication number: 20140073764
    Abstract: The present invention relates to unnatural amino acids comprising a cyclooctynyl or trans-cyclooctenyl analog group and having formula (I) or an acid or base addition salt thereof. The invention also relates to the use of said unnatural amino acids, kits and processes for preparation of polypeptides that comprise one or more than one cyclooctynyl or trans-cyclooctenyl analog group. These polypeptides can be covalently modified by in vitro or in vivo reaction with compounds comprising an azide, nitrile oxide, nitrone, diazocarbonyl or 1,2,4,5-tetrazine group.
    Type: Application
    Filed: February 3, 2012
    Publication date: March 13, 2014
    Applicant: EMBL
    Inventors: Edward Lemke, Carsten Schultz, Tilman Plass, Sigrid Milles, Christine Koehler