Patents by Inventor Tilman Seytter

Tilman Seytter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Active hedgehog protein conjugate
    Publication number: 20070191274
    Abstract: A hedgehog conjugate which is characterized in that it contains: a) a polypeptide composed of 10 to 30 hydrophobic amino acids and/or amino acids which form transmembrane helices and are positively charged, b) 1 to 4 aliphatic, saturated or unsaturated hydrocarbon residues with a chain length of 10 to 24 C atoms and with a hydrophobic action or c) a hydrophobic thio compound covalently bound to a hedgehog protein and which has a several-fold increased activity and is suitable as a pharmaceutical agent.
    Type: Application
    Filed: December 22, 2006
    Publication date: August 16, 2007
    Inventors: Angelika Esswein, Kurt Lang, Petra Rueger, Tilman Seytter
  • Active modified hedgehog proteins
    Patent number: 6994990
    Abstract: The present invention provides isolated highly active hedgehog proteins esterified with a fatty acid having from 14 to 20 carbon atoms at the N-terminal domain of the protein. The highly active hh proteins are particularly useful therapeutic agents for treating bone disorders and neurodegenerative diseases. Methods for obtaining the highly active modified hedgehog proteins are also provided.
    Type: Grant
    Filed: November 24, 1998
    Date of Patent: February 7, 2006
    Assignee: Curis, Inc.
    Inventors: Kurt Lang, Ulrike Leser, Tilman Seytter
  • Active hedgehog protein conjugate
    Publication number: 20050148510
    Abstract: A hedgehog conjugate which is characterized in that it contains: a) a polypeptide composed of 10 to 30 hydrophobic amino acids and/or amino acids which form transmembrane helices and are positively charged, b) 1 to 4 aliphatic, saturated or unsaturated hydrocarbon residues with a chain length of 10 to 24 C atoms and with a hydrophobic action or c) a hydrophobic thio compound covalently bound to a hedgehog protein and which has a several-fold increased activity and is suitable as a pharmaceutical agent.
    Type: Application
    Filed: October 8, 2004
    Publication date: July 7, 2005
    Applicant: Curis, Inc.
    Inventors: Angelika Esswein, Kurt Lang, Petra Rueger, Tilman Seytter
  • Active hedgehog protein conjugate
    Patent number: 6818623
    Abstract: A hedgehog conjugate which is characterized in that it contains: a) a polypeptide composed of 10 to 30 hydrophobic amino acids and/or amino acids which form transmembrane helices and are positively charged, b) 1 to 4 aliphatic, saturated or unsaturated hydrocarbon residues with a chain length of 10 to 24 C atoms and with a hydrophobic action or c) a hydrophobic thio compound covalently bound to a hedgehog protein and which has a several-fold increased activity and is suitable as a pharmaceutical agent.
    Type: Grant
    Filed: October 21, 2002
    Date of Patent: November 16, 2004
    Assignee: Curis, Inc.
    Inventors: Angelika Esswein, Kurt Lang, Petra Rueger, Tilman Seytter
  • Active hedgehog protein conjugate
    Publication number: 20030139574
    Abstract: A hedgehog conjugate which is characterized in that it contains: a) a polypeptide composed of 10 to 30 hydrophobic amino acids and/or amino acids which form transmembrane helices and are positively charged, b) 1 to 4 aliphatic, saturated or unsaturated hydrocarbon residues with a chain length of 10 to 24 C atoms and with a hydrophobic action or c) a hydrophobic thio compound covalently bound to a hedgehog protein and which has a several-fold increased activity and is suitable as a pharmaceutical agent.
    Type: Application
    Filed: October 21, 2002
    Publication date: July 24, 2003
    Inventors: Angelika Esswein, Kurt Lang, Petra Rueger, Tilman Seytter
  • Active hedgehog protein conjugate
    Patent number: 6468978
    Abstract: A hedgehog conjugate which is characterized in that it contains: a) a polypeptide composed of 10 to 30 hydrophobic amino acids and/or amino acids which form transmembrane helices and are positively charged, b) 1 to 4 aliphatic, saturated or unsaturated hydrocarbon residues with a chain length of 10 to 24 C atoms and with a hydrophobic action or c) a hydrophobic thio compound covalently bound to a hedgehog protein and which has a several-fold increased activity and is suitable as a pharmaceutical agent.
    Type: Grant
    Filed: April 28, 1999
    Date of Patent: October 22, 2002
    Assignee: Curis, Inc.
    Inventors: Angelika Esswein, Kurt Lang, Petra Rueger, Tilman Seytter