Patents by Inventor Tim A. Smitka

Tim A. Smitka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • A89271 factors and processes for their production
    Patent number: 5457119
    Abstract: New hapalindole-type alkaloids called A89271 A-F and I are antifungal and antitumor agents. Methods for preparing them and for preparing hapalindoles G and H by culturing the blue-green alga Fischerella ambigua ATCC 55210 are provided. Methods for preparing A89271 factors B and F by culturing the blue-green alga Hapalosiphon hibernicus ATCC 55225 and a biologically pure culture of this alga are also provided. Further provided are methods and compositions for the inhibition of fungal growth and the treatment of susceptible neoplasms.
    Type: Grant
    Filed: July 8, 1994
    Date of Patent: October 10, 1995
    Assignee: Eli Lilly and Company
    Inventors: Roseanne Bonjouklian, Richard E. Moore, Gregory M. L. Patterson, Tim A. Smitka
  • Hapalosiphon hibernicus
    Patent number: 5366890
    Abstract: New hapalindole-type alkaloids called A89271 A-F and I are antifungal and antitumor agents. Methods for preparing them and for preparing hapalindoles G and H by culturing the blue-green alga Fischerella ambigua ATCC 55210 are provided. Methods for preparing A89271 factors B and F by culturing the blue-green alga Hapalosiphon hibernicus ATCC 55225 and a biologically pure culture of this alga are also provided. Further provided are methods and compositions for the inhibition of fungal growth and the treatment of susceptible neoplasms.
    Type: Grant
    Filed: October 13, 1993
    Date of Patent: November 22, 1994
    Assignee: Eli Lilly and Company
    Inventors: Roseanne Bonjouklian, Richard E. Moore, Gregory M. L. Patterson, Tim A. Smitka
  • Preparation of hapalindole-related alkaloids from blue-green algae
    Patent number: 5292650
    Abstract: New hapalindole-type alkaloids called A89271 A-F and I are antifungal and antitumor agents. Methods for preparing them and for preparing hapalindoles G and H by culturing the blue-green alga Fischerella ambigua ATCC 55210 are provided. Methods for preparing A89271 factors B and F by culturing the blue-green alga Hapalosiphon hibernicus ATCC 55225 and a biologically pure culture of this alga are also provided. Further provided are methods and compositions for the inhibition of fungal growth and the treatment of susceptible neoplasms.
    Type: Grant
    Filed: September 16, 1992
    Date of Patent: March 8, 1994
    Assignees: Eli Lilly and Company, University of Hawaii
    Inventors: Roseanne Bonjouklian, Richard E. Moore, Gregory M. L. Patterson, Tim A. Smitka
  • Strain of streptomyces for producing avermectins and processes therewith
    Patent number: 5292647
    Abstract: A new microorganism, Streptomyces avermitilis subspecies niger NRRL 21005, and processes using the microorganism for producing known avermectins are provided.
    Type: Grant
    Filed: November 30, 1992
    Date of Patent: March 8, 1994
    Assignee: Eli Lilly and Company
    Inventors: Rosanne Bonjouklian, Otis W. Godfrey, Tim A. Smitka, Raymond C. Yao
  • Hapalindoles
    Patent number: 4870185
    Abstract: New alkaloids called hapalindoles J-Q and T-V, which are antibacterial and antifungal agents, and methods of preparing these alkaloids by culturing the blue-green alga Hapalosiphon fontinalis ATCC 39694, are provided.
    Type: Grant
    Filed: September 18, 1986
    Date of Patent: September 26, 1989
    Assignees: Eli Lilly and Company, University of Hawaii
    Inventors: Rosanne Bonjouklian, Richard E. Moore, Jon S. Mynderse, Gregory M. L. Patterson, Tim A. Smitka
  • Antimicrobial and antitumor phenazine carboxaldehydes and derivatives
    Patent number: 4657909
    Abstract: Acids, esters, imine acids, imine esters, and imine amides derived from 6-formyl-4,7,9-trihydroxy-1-phenazinecarboxylic acid, methyl ester and from 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester demonstrate antimicrobial and antineoplastic activity.A purified strain of Streptomyces galanosa, NRRL 15738, is capable of producing 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester in isolable quantities from a fermentation broth containing assimilable sources of carbon and nitrogen.
    Type: Grant
    Filed: June 10, 1985
    Date of Patent: April 14, 1987
    Assignee: Warner-Lambert Company
    Inventors: Christopher F. Bigge, Edward F. Elslager, James C. French, Blanche D. Graham, Gerard C. Hokanson, Stephen W. Mamber, Tim A. Smitka, Josefino B. Tunac, John H. Wilton
  • CL-1577 Antibiotic compounds and their production
    Patent number: 4530835
    Abstract: A purified isolate of an actinomycete identified as ATCC 39363 is capable of producing a complex of sulfur-containing antibiotic compounds having activity against transplanted tumors.Antibiotic compounds CL-1577A and CL-1577B and their closely related congeners are produced by cultivating isolate ATCC 39363 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1577 complex is produced, and subsequently isolating the complex or one or more of the compounds.The antibiotic compounds CL-1577A, CL-1577B, their congeners, and pharmaceutical compositions comprising these substances together with a suitable carrier are also disclosed.
    Type: Grant
    Filed: July 8, 1983
    Date of Patent: July 23, 1985
    Assignee: Warner-Lambert Company
    Inventors: Richard H. Bunge, James C. French, Timothy R. Hurley, Tim A. Smitka, Josefino B. Tunac
  • 12'-Hydroxyverrucarin J and iso-satratoxin H
    Patent number: 4436750
    Abstract: The present invention relates to the novel trichothecenes, 12'-hydroxyverrucarin J and iso-satratoxin H, and a fermentation process for the production of said compounds.The invention also relates to pharmaceutical compositions comprising said compounds and methods for using said compositions.
    Type: Grant
    Filed: October 4, 1982
    Date of Patent: March 13, 1984
    Assignee: Warner-Lambert Company
    Inventors: Tim A. Smitka, Richard H. Bunge, James C. French, Russell J. Bloem