Abstract: The invention relates to novel compounds of formula (I), the compounds being capable of acting as av?6 integrin antagonists, their use in the treatment of disease, their methods of manufacture and compositions comprising said compounds for such purposes (I) wherein R1 is selected from: R1a, —C(O)R1a, —C(O)OR1a —C(O)NHR1a, —C(O)N(R1a)2, —SO2R1a, wherein R1a are each independently selected from: alkyl, alkenyl, alkynyl, aryl, heteroaryl, alkylaryl or alkylheteroaryl, each of which may be optionally substituted; R2 is selected from: hydrogen, halogen, optionally substituted alkyl or optionally substituted alkoxyl; R2a are each independently selected from: hydrogen, halogen, optionally substituted alkyl or optionally substituted alkoxyl; R3 is selected from: hydrogen, optionally substituted alkyl or optionally substituted alkoxyl; R4 is hydroxyl; Ar1 is an optionally substituted heteroaryl or bicyclic heteroaryl; and L is a linker; or a pharmaceutically acceptable salt thereof.

Abstract: The invention relates to novel compounds of formula (I), the compounds being capable of acting as av?6 integrin antagonists, their use in the treatment of disease, their methods of manufacture and compositions comprising said compounds for such purposes (I) wherein R1 is selected from: R1a, —C(O)R1a, —C(O)OR1a —C(O)NHR1a, —C(O)N(R1a)2, —SO2R1a, wherein R1a are each independently selected from: alkyl, alkenyl, alkynyl, aryl, heteroaryl, alkylaryl or alkylheteroaryl, each of which may be optionally substituted; R2 is selected from: hydrogen, halogen, optionally substituted alkyl or optionally substituted alkoxyl; R2a are each independently selected from: hydrogen, halogen, optionally substituted alkyl or optionally substituted alkoxyl; R3 is selected from: hydrogen, optionally substituted alkyl or optionally substituted alkoxyl; R4 is hydroxyl; Ar1 is an optionally substituted heteroaryl or bicyclic heteroaryl; and L is a linker; or a pharmaceutically acceptable salt thereof.

Abstract: The invention relates to a compound which is (S)-4-((S)-3-Fluoro-3-(2-(5,6,7,8-tetrahydro-1, 8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)-3-(3-(2-methoxyethoxy)phenyl) butanoic acid (1:1) citrate salt, pharmaceutical compositions including such compound, and to the use of such compound in therapy, including in the treatment of a disease or condition for which an ?vJ36 integrin antagonist is indicated, and in particular idiopathic pulmonary fibrosis.

Abstract: A method of delivering video on demand content, including multicasting content to a plurality of client devices with storage, including instances where delivery begins mid-stream, and recovery mechanisms for missing content. Some embodiments include defining content as mandatory and involuntarily delivering the mandatory content. Some embodiments include a carousel with a plurality of data sets, delivering each of the data sets in sequence, and then beginning repeating delivery circularly from the beginning of the sequence. Various exemplary embodiments include one or more of the following: storing a title at each client device; repeating various steps for more multiple titles; and monitoring for a required action such as downloading a new title, deleting an old title, or changing the rate of data transfer, and performing the required action.

Abstract: A spatial monitoring-correlation mechanism and a method are described herein for determining an origin of a problem within an Internet Protocol Television (IPTV) network by using topology information about the IPTV network and at least one error notification (e.g., packet loss notification-retransmission request) that is generated by at least one component (e.g., set-top box) within the IPTV network.

Abstract: The invention provides for systems, methods, and a transport re-encapsulator/tagger for delivering streaming media to customer premises equipment. A digital streaming media system broadcasts streaming media to provider networks which use middleware which has certain requirements for the transport encapsulation and tagging of headers of the streaming media. The invention provides for re-encapsulating/tagging of media broadcasts having one type of transport encapsulation/tagging into a type of transport encapsulation/tagging required by the middleware.

Abstract: A monitoring system and method are described herein that obtain retry request information from packet recovery server(s) and based at least in part on the obtained retry request information determine whether or not to launch probes to monitor specific network element(s) within an Internet Protocol Television (IPTV) network to diagnose a problem without having to monitor everyone of the network elements all of the time.

Abstract: In various exemplary embodiments, a method of monitoring performance of a server and a related computer-readable medium include one or more of the following: placing a load agent on at least one server; maintaining a load on the server using the load agent, wherein the load corresponds to at least one predetermined performance parameter of the server; monitoring the at least one predetermined performance parameter on the server; and gathering performance information while the load agent is monitoring the server. In various exemplary embodiments, the performance parameters include CPU usage, memory usage, network load, and disk performance. Thus, various exemplary embodiments enable a precise determination of the effect on application requests received by the server when the server is under a specific load.

Abstract: A spatial monitoring-correlation mechanism and a method are described herein for determining an origin of a problem within an Internet Protocol Television (IPTV) network by using topology information about the IPTV network and at least one error notification (e.g., packet loss notification-retransmission request) that is generated by at least one component (e.g., set-top box) within the IPTV network.

Abstract: A method of delivering video on demand content, including multicasting content to a plurality of client devices with storage, including instances where delivery begins mid-stream, and recovery mechanisms for missing content. Some embodiments include defining content as mandatory and involuntarily delivering the mandatory content. Some embodiments include a carousel with a plurality of data sets, delivering each of the data sets in sequence, and then beginning repeating delivery circularly from the beginning of the sequence. Various exemplary embodiments include one or more of the following: storing a title at each client device; repeating various steps for more multiple titles; and monitoring for a required action such as downloading a new title, deleting an old title, or changing the rate of data transfer, and performing the required action.

Abstract: The invention provides for systems, methods, and a transport re-encapsulator/tagger for delivering streaming media to customer premises equipment. A digital streaming media system broadcasts streaming media to provider networks which use middleware which has certain requirements for the transport encapsulation and tagging of headers of the streaming media. The invention provides for re-encapsulating/tagging of media broadcasts having one type of transport encapsulation/tagging into a type of transport encapsulation/tagging required by the middleware.

Abstract: A method of delivering video on demand content, including selecting a video on demand asset, determining a portion of the asset that is stored on a storage media local to a client, playing the portion of the asset that is stored on the storage media local to the client from the local storage media, determining a portion of the asset that is not stored on a storage media local to the client, and playing the portion of the asset that is not stored on the storage medial local to the client off a remote server via unicast in combination with the playing the portion of the asset that is stored on the storage media local to the client.

Abstract: An apparatus and method for managing requests for video on demand media data for effecting VoD stream delivery, including an interface for receiving data requests addressed for processing by a particular data request service device, an agent operatively coupled to the interface and configured for selecting which of a number of different data request service devices to send the request, irrespective of the device to which the request is addressed, and/or a module for determining if a received request can be serviced by a preferred request service device based on its ability to service the request. In some embodiments, when the preferred device is capable of servicing the request, the request is directed to that device, otherwise to another device, possibly the device to which the request is originally addressed. In some embodiments, the preferred request service device resides at an access node for delivering media services to subscriber equipment.

Abstract: A system, method, and computer readable medium for a customer premises equipment based advertisement insertion mechanism for Internet Protocol based networks, comprises, storing advertisements in a customer premises equipment, detecting an advertisement insertion signal in a data stream, and multiplexing the stored advertisements into the data stream upon the detecting of the advertisement insertion signal.