Abstract: Systems for identifying the composition of bioaerosol particles using a TOFMS MALDI matrix-less system. A continuous timing laser triggers an IR ionization laser to fire when each particle enters the beam of the continuous trigger laser and is used to determine optical properties of the aerosol particles in association with one or more laser scattering devices and generate optical data. Ionized fragments produced when each particle is struck by the pulse ionization laser are analyzed using a TOFMS detector. A data analysis system is configured to compile the optical data with unique mass spectral data associated with each particle using data fusion and compare the compiled optical data with a training data set comprising of a knowledge base of known aerosol particles to predict composition.

Abstract: Systems for identifying the composition of aerosol particles, particularly that of non-biological aerosol particles or biological aerosol particles including surface-bound water. A continuous timing laser triggers an IR ionization laser to fire when each particle enters the beam of the continuous trigger laser and determine optical properties of the aerosol particles in association with one or more laser scattering devices and generate optical data. The continuous laser beam and the pulse ionization laser beam are disposed as overlapping beams. Ionized fragments produced when each particle is struck by the ionization laser are analyzed using a TOFMS detector. A data analysis system is configured to compile the optical data with unique mass spectral data associated with each particle using data fusion and compare the compiled optical data with a training data set comprising of a knowledge base of known aerosol particles to predict composition.

Abstract: Disclosed are systems are methods for identifying the composition of single aerosol particles, particularly that of bioaerosol particles. A continuous timing laser tightly coupled with a pulse ionization laser is used to index aerosol particles, measure particle properties, and trigger the ionization laser to fire when each particle enters the beam of the trigger laser. Ionized fragments and optionally photons produced when each particle is struck by the ionization laser are analyzed using one or more detectors including a TOF-MS detector and an optical detector. Individual single particle spectra are aligned and denoised prior to averaging.

Abstract: Disclosed are systems are methods for identifying the composition of single aerosol particles, particularly that of bioaerosol particles. A continuous timing laser tightly coupled with a pulse ionization laser is used to index aerosol particles, measure particle properties, and trigger the ionization laser to fire when each particle enters the beam of the trigger laser. Ionized fragments and optionally photons produced when each particle is struck by the ionization laser are analyzed using one or more detectors including a TOF-MS detector and an optical detector. Individual single particle spectra are aligned and denoised prior to averaging.