Abstract: The present disclosure provides variant OmpG polypeptides, compositions comprising the OmpG variant polypeptides, and methods for using the variant OmpG polypeptides as nanopores for determining the sequence of single stranded nucleic acids. The variant OmpG nanopores reduce the ionic current noise versus the parental OmpG polypeptide from which they are derived and thereby enable sequencing of polynucleotides with single nucleotide resolution. The reduced ionic current noise also provides for the use of these OmpG nanopore variants in other single molecule sensing applications, e.g., protein sequencing.

Abstract: The present disclosure provides variant OmpG polypeptides, compositions comprising the OmpG variant polypeptides, and methods for using the variant OmpG polypeptides as nanopores for determining the sequence of single stranded nucleic acids. The variant OmpG nanopores reduce the ionic current noise versus the parental OmpG polypeptide from which they are derived and thereby enable sequencing of polynucleotides with single nucleotide resolution. The reduced ionic current noise also provides for the use of these OmpG nanopore variants in other single molecule sensing applications, e.g., protein sequencing.

Abstract: The present disclosure provides variant OmpG polypeptides, compositions comprising the OmpG variant polypeptides, and methods for using the variant OmpG polypeptides as nanopores for determining the sequence of single stranded nucleic acids. The variant OmpG nanopores reduce the ionic current noise versus the parental OmpG polypeptide from which they are derived and thereby enable sequencing of polynucleotides with single nucleotide resolution. The reduced ionic current noise also provides for the use of these OmpG nanopore variants in other single molecule sensing applications, e.g., protein sequencing.

Abstract: The present disclosure provides variant OmpG polypeptides, compositions comprising the OmpG variant polypeptides, and methods for using the variant OmpG polypeptides as nanopores for determining the sequence of single stranded nucleic acids. The variant OmpG nanopores reduce the ionic current noise versus the parental OmpG polypeptide from which they are derived and thereby enable sequencing of polynucleotides with single nucleotide resolution. The reduced ionic current noise also provides for the use of these OmpG nanopore variants in other single molecule sensing applications, e.g., protein sequencing.

Abstract: A carrier system that includes a multi-curve front body armor plate that is wearable on a front torso having a protruding chest. The strike face has a lower region with a lower convex portion shaped to follow a cylindrical contour of an abdomen and chest of the torso. An upper portion of the strike face laterally tapers to a top edge and curves backwardly to accommodate the protruding chest. An armor carrier of the carrier system includes (i) a back panel; (ii) a front panel having an opening that is sized to receive the multi-curve front body armor plate; and (iii) a shoulder harness connecting the front and back panels. The shoulder harness providing a support surface that rests upon shoulders of a wearer.

Abstract: The present disclosure provides variant OmpG polypeptides, compositions comprising the OmpG variant polypeptides, and methods for using the variant OmpG polypeptides as nanopores for determining the sequence of single stranded nucleic acids. The variant OmpG nanopores reduce the ionic current noise versus the parental OmpG polypeptide from which they are derived and thereby enable sequencing of polynucleotides with single nucleotide resolution. The reduced ionic current noise also provides for the use of these OmpG nanopore variants in other single molecule sensing applications, e.g., protein sequencing.

Abstract: The present disclosure provides variant OmpG polypeptides, compositions comprising the OmpG variant polypeptides, and methods for using the variant OmpG polypeptides as nanopores for determining the sequence of single stranded nucleic acids. The variant OmpG nanopores reduce the ionic current noise versus the parental OmpG polypeptide from which they are derived and thereby enable sequencing of polynucleotides with single nucleotide resolution. The reduced ionic current noise also provides for the use of these OmpG nanopore variants in other single molecule sensing applications, e.g., protein sequencing.

Abstract: Aspects of the present disclosure involve a system and method for journaling transactions and identifying and correcting transaction errors. In one embodiment, a system is introduced that includes isolated clusters that are capable of journaling the state of a transaction after every critical step. In another embodiment, the system is introduced that can sweep the journaled transactions in order to identify post-processing transactional errors. Still in another embodiment, a system is introduced that is capable of performing a self-correcting mechanism that enables error correction in the background without presenting a failed notification to a customer.

Abstract: The present disclosure provides variant OmpG polypeptides, compositions comprising the OmpG variant polypeptides, and methods for using the variant OmpG polypeptides as nanopores for determining the sequence of single stranded nucleic acids. The variant OmpG nanopores reduce the ionic current noise versus the parental OmpG polypeptide from which they are derived and thereby enable sequencing of polynucleotides with single nucleotide resolution. The reduced ionic current noise also provides for the use of these OmpG nanopore variants in other single molecule sensing applications, e.g., protein sequencing.

Abstract: The systems and methods that warm-up a virtual machine are provided. An application byte code is generated from an application source code for an application that processes time-sensitive messages using a virtual machine. The virtual machine is configured to interpret the application byte code. A warm-up data is received by the virtual machine. The warm-up data is configured to emulate one or more time-sensitive messages processed by the virtual machine. From the warm-up data, the virtual machine generates application machine-readable code from the application byte code, and stores the application machine-readable code. After the virtual machine generates the application machine-readable code, a computing device that includes the virtual machine is placed in a real-world environment and begins to receive the time-sensitive messages. The virtual machine processes the time-sensitive messages using the generated application machine-readable code.

Abstract: An apparatus and method for performing counter flow centrifugation. The apparatus includes at least one vessel, a gear fixedly attached to at least a portion of the vessel such that rotation of the gear rotates the vessel, a handle assembly and a plurality of tubes extending through the handle assembly and to the vessel. The gear is configured to be rotated by a drive system. The handle assembly is rotatably attached to the gear and includes an opening therein. At least a portion of the gear engages at least a portion of the drive system through the opening. The handle assembly is configured to be rotated by the drive system. The vessel can be rotated at twice a speed of the handle assembly when the apparatus is inserted into a bowl of the counter flow centrifuge.

Abstract: The systems and methods that warm-up a virtual machine are provided. An application byte code is generated from an application source code for an application that processes time-sensitive messages using a virtual machine. The virtual machine is configured to interpret the application byte code. A warm-up data is received by the virtual machine. The warm-up data is configured to emulate one or more time-sensitive messages processed by the virtual machine. From the warm-up data, the virtual machine generates application machine-readable code from the application byte code, and stores the application machine-readable code. After the virtual machine generates the application machine-readable code, a computing device that includes the virtual machine is placed in a real-world environment and begins to receive the time-sensitive messages. The virtual machine processes the time-sensitive messages using the generated application machine-readable code.

Abstract: An apparatus of a counter flow centrifuge can include at least one vessel, a handle assembly, and a plurality of tubes extending through the handle assembly and to the vessel. The vessel can be rotated at twice a speed of the handle assembly when the apparatus is inserted into a bowl of the counter flow centrifuge.

Abstract: Methods and systems for automated display of music data in a music display system. In one embodiment, a method for distinguishing lyrics and notations of a music data file is provided. In one embodiment, the lyrics are automatically shown in a different color or other display appearance relative to the notations. In another embodiment, the key of the notations is automatically determined and stored and/or displayed. In another embodiment, zoom in and zoom out capability is provided by automatically changing the font to appropriate permitted sizes, and/or by automatically determining the relative pixel spacing of the words in the lyric lines and the musical notation lines in the corresponding musical notation lines and selecting a font that maintains adequate spacing. Other inventive music display file presentation, storage, and analysis capabilities and features also are disclosed.

Abstract: A child resistant senior friendly medication storage and distribution package including a blister portion and a blocking substrate sandwiched between a dispensing substrate and a backing substrate. The procedure to access the medicament is easy for an adult to understand and accomplish, yet difficult for most children. The blister portion contains a base layer and a blister layer. The blister layer includes an article receiving blister designed for holding the medicament. The dispensing substrate has a dispensing substrate blister receiver. The blister receiver is configured to cooperate with the blister so it extends through the dispensing substrate. The blocking substrate includes a gate that initially covers a portion of the blister. The gate must be moved, or slid, out of the way in order to eject the medicament. The user applies a force to the gate causing it to translate between the backing substrate and the dispensing substrate.

Abstract: Methods and systems for automated display of music data in a music display system. In one embodiment, a method for distinguishing lyrics and notations of a music data file is provided. In one embodiment, the lyrics are automatically shown in a different color or other display appearance relative to the notations. In another embodiment, the key of the notations is automatically determined and stored and/or displayed. In another embodiment, zoom in and zoom out capability is provided by automatically changing the font to appropriate permitted sizes, and/or by automatically determining the relative pixel spacing of the words in the lyric lines and the musical notation lines in the corresponding musical notation lines and selecting a font that maintains adequate spacing. Other inventive music display file presentation, storage, and analysis capabilities and features also are disclosed.

Abstract: A system and method for displaying one or more images on multiple remote displays. An image is selected to be displayed on one or more remote displays and a remote image file is generated for the selected image. The remote image file is transmitted to one or more remote displays and the one or more remote displays are configured to display an image corresponding to the remote image file.

Abstract: Method for transmitting digital sheet music from a music database to a local music management system. Establishing a connection between the music database and the local music management system. Digital sheet music data files are sent from the music database to the local music management system. Methods of encrypting digital sheet music data files.

Abstract: A child resistant senior friendly medication storage and distribution package including a blister portion and a blocking substrate sandwiched between a dispensing substrate and a backing substrate. The procedure to access the medicament is easy for an adult to understand and accomplish, yet difficult for most children. The blister portion contains a base layer and a blister layer. The blister layer includes an article receiving blister designed for holding the medicament. The dispensing substrate has a dispensing substrate blister receiver. The blister receiver is configured to cooperate with the blister so it extends through the dispensing substrate. The blocking substrate includes a gate that initially covers a portion of the blister. The gate must be moved, or slid, out of the way in order to eject the medicament. The user applies a force to the gate causing it to translate between the backing substrate and the dispensing substrate.

Abstract: A child-resistant medicament storage and distribution back card for senior-friendly and child-resistant distribution of a medicament. The back card is incorporated into a medication package where it protects the area of the package that is most susceptible to attacks on the integrity of the package. The back card has a card opening feature bounded by a perimeter that includes at least two cuts and at least two lands, often thought of as perforations. The cuts extend through the back card, and the lands connect the back card to the card opening feature. Each cut has a cut length and each land has a land length. The ratio of any land length to any cut length is between approximately 0.25 and approximately 0.