Patents by Inventor Tim Fox

Tim Fox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210139927
    Abstract: A nuclear maize gene is mutated to result in dominant male sterility. Two mutants are provided which impact signal peptide processing. Restoration constructs and methods are provided for use of the dominant male-sterile mutants in producing hybrid seed for male-sterile hybrid plants. Other signal-peptide modifications are provided. Orthologs of the wild type or mutated gene in various species are provided.
    Type: Application
    Filed: November 20, 2020
    Publication date: May 13, 2021
    Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: MARC C ALBERTSEN, TIM FOX, APRIL L LEONARD, BAILIN LI, BRIAN R LOVELAND, MARY TRIMNELL
  • Patent number: 10870860
    Abstract: A nuclear maize gene is mutated to result in dominant male sterility. Two mutants are provided which impact signal peptide processing. Restoration constructs and methods are provided for use of the dominant male-sterile mutants in producing hybrid seed for male-sterile hybrid plants. Other signal-peptide modifications are provided. Orthologs of the wild type or mutated gene in various species are provided.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: December 22, 2020
    Inventors: Marc C Albertsen, Tim Fox, April L Leonard, Bailin Li, Brian R Loveland, Mary Trimnell
  • Publication number: 20200263189
    Abstract: Plant cell fate and development is altered by treating cells with cellular reprogramming factors. Embryogenesis inducing morphogenic developmental genes are used as cellular reprogramming factors, specifically comprising polypeptides or polynucleotides encoding gene products for generating doubled haploids or haploid plants from gametes. Maize microspores treated by contacting the isolated cells with an exogenous purified, recombinant embryogenesis inducing morphogenic developmental gene polypeptide results in embryogenesis. The gametes of a maize plant develop into embryoids when transformed with a genetic construct including regulatory elements and structural genes capable of acting in a cascading fashion to alter cellular fate of plant cells. Developmental morphogenic proteins expressed from a genetic construct are used for ex situ treatment methods and for in planta cellular reprogramming.
    Type: Application
    Filed: October 12, 2018
    Publication date: August 20, 2020
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: TIM FOX, WILLIAM JAMES GORDON-KAMM, RACHEL CAROL HUEGEL, KEITH S LOWE, JON AARON TUCKER REINDERS, HUAXUN YE
  • Patent number: 10548276
    Abstract: Genetic male sterile plants are provided in which complementing constructs result in suppression of a parental phenotype in the progeny. Methods to generate and maintain such plants and methods of use of said plants, are provided, including use of parental plants to produce sterile plants for hybrid seed production.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: February 4, 2020
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Tim Fox, Dale F. Loussaert, Jeffrey Schussler, Juan Pablo San Martin Toloza, Bo Shen
  • Publication number: 20190211354
    Abstract: A nuclear maize gene is mutated to result in dominant male sterility. Two mutants are provided which impact signal peptide processing. Restoration constructs and methods are provided for use of the dominant male-sterile mutants in producing hybrid seed for male-sterile hybrid plants. Other signal-peptide modifications are provided. Orthologs of the wild type or mutated gene in various species are provided.
    Type: Application
    Filed: November 19, 2018
    Publication date: July 11, 2019
    Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: MARC C. ALBERTSEN, TIM FOX, APRIL L. LEONARD, BAILIN LI, BRIAN R. LOVELAND, MARY TRIMNELL
  • Publication number: 20190177722
    Abstract: Compositions and methods are provided for genome modification of a nucleotide sequence located in or near a male fertility gene of MS9, MS22, MS26, or MS45 in the genome of a plant cell or plant to produce a male-sterile plant. In some examples, the methods and compositions employ a guide RNA/Cas endonuclease system for modifying or altering target sites located in or near a male fertility gene of MS9, MS22, MS26, or MS45 in the genome of a plant cell, plant or seed to produce a male-sterile plant. Also provided are compositions and methods employing a guide polynucleotide/Cas endonuclease system for genome modification a nucleotide sequence located in or near a male fertility gene of MS9, MS22, MS26, or MS45 in the genome of a plant cell to produce a male-sterile plant. Compositions and methods are also provided for restoring fertility to a Ms9, Ms22, Ms26, or Ms45 nucleotide sequence to a male-sterile Ms9, Ms22, Ms26, or Ms45 plant produced using the methods and compositions described herein.
    Type: Application
    Filed: December 10, 2018
    Publication date: June 13, 2019
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: ANDREW MARK CIGAN, TIM FOX, MANJIT SINGH
  • Publication number: 20190024102
    Abstract: Genetic male sterile plants are provided in which complementing constructs result in suppression of a parental phenotype in the progeny. Methods to generate and maintain such plants and methods of use of said plants, are provided, including use of parental plants to produce sterile plants for hybrid seed production.
    Type: Application
    Filed: August 30, 2017
    Publication date: January 24, 2019
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: TIM FOX, DALE F. LOUSSAERT, JEFFREY SCHUSSLER, JUAN PABLO SAN MARTIN TOLOZA, BO SHEN
  • Patent number: 10155961
    Abstract: A nuclear maize gene is mutated to result in dominant male sterility. Two mutants are provided which impact signal peptide processing. Restoration constructs and methods are provided for use of the dominant male-sterile mutants in producing hybrid seed for male-sterile hybrid plants. Other signal-peptide modifications are provided. Orthologs of the wild type or mutated gene in various species are provided.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: December 18, 2018
    Assignees: PIONEER HI-BRED INTERNATIONAL. INC., E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Marc Albertsen, Tim Fox, April Leonard, Bailin Li, Brian Loveland, Mary Trimnell
  • Publication number: 20180258445
    Abstract: Nucleotide sequences, amino acid sequences, and an associated promoter sequence are useful in methods of controlling male fertility in plants. Recombinant expression cassettes, vectors, plant cells, and plants comprise a disclosed nucleotide sequence and may encode a disclosed amino acid sequence. The recombinant expression cassettes are useful in controlling fertility, especially male fertility of annual crops. The promoter is useful in driving expression of an operably-linked heterologous polynucleotide. Constructs comprising homology to the promoter sequence are useful for downregulation of a polynucleotide associated with the promoter.
    Type: Application
    Filed: May 14, 2018
    Publication date: September 13, 2018
    Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: MARC C ALBERTSEN, TIM FOX, APRIL LEONARD, BAILIN LI, BRIAN LOVELAND, MARY TRIMNELL
  • Publication number: 20170342430
    Abstract: Pairs of plants are provided in which complementing constructs result in suppression of a parental phenotype in the progeny. Methods to generate and maintain such plants and methods of use of said plants, are provided, including use of parental plants to produce sterile plants for hybrid seed production. Also provided are methods for maintaining a homozygous recessive condition and for repressing transmission of transgenes.
    Type: Application
    Filed: August 10, 2017
    Publication date: November 30, 2017
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: ANDREW MARK CIGAN, TIM FOX, HOWARD P HERSHEY, ERICA UNGER-WALLACE, YONGZHONG WU
  • Patent number: 9803215
    Abstract: Nucleotide sequences of a Msca1 gene, critical to male fertility in plants are described, with DNA molecule and amino acid sequences set forth. Promoter sequences and their essential regions are also identified. The nucleotide sequences are useful in impacting male fertility in plants.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: October 31, 2017
    Assignees: PIONEER HI-BRED INTERNATIONAL, INC., E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Marc Albertsen, Tim Fox, Mary Trimnell, Yongzhong Wu, Keith Lowe
  • Publication number: 20170290279
    Abstract: Disclosed are methods of obtaining clonal seeds, methods of plant cloning, methods of screening for maternal plants that produce clonal seeds asexually and methods of increasing yield of clonal seeds. Also disclosed are constructs comprising a nucleic acid that may silence the activity of a RNA-dependent DNA methylation pathway gene. Further disclosed are maternal plants comprising a construct wherein the construct comprises an exogenous nucleic acid sequence, wherein the construct renders the maternal plant defective for RNA-dependent DNA methylation.
    Type: Application
    Filed: September 21, 2015
    Publication date: October 12, 2017
    Inventors: Shai J. Lawit, Marc C. Albertsen, Tim Fox, William Gordon-Kamm, Michelle M. Van Allen, Jean-Philippe Vielle Calzada, Carlos Barragan Rosillo, Edgar Demesa Arevalo, Carlos Gonzalez Chavez, Elvira Hemandez Lagana, Gloria Leon Martinez, Nidia Sanchez Leon, Daniel Rodriguez Leal, Isaac Rodriguez Arevalo, Jaime Padilla Calzada
  • Patent number: 9783814
    Abstract: Genetic male sterile plants are provided in which complementing constructs result in suppression of a parental phenotype in the progeny. Methods to generate and maintain such plants and methods of use of said plants, are provided, including use of parental plants to produce sterile plants for hybrid seed production.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: October 10, 2017
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Tim Fox, Dale F Loussaert, Jeffrey Schussler, Juan Pablo San Martin Toloza, Bo Shen
  • Publication number: 20160264993
    Abstract: Nucleotide sequences of a Msca1 gene, critical to male fertility in plants are described, with DNA molecule and amino acid sequences set forth. Promoter sequences and their essential regions are also identified. The nucleotide sequences are useful in impacting male fertility in plants.
    Type: Application
    Filed: November 17, 2014
    Publication date: September 15, 2016
    Inventors: Marc Albertsen, Tim Fox, Mary Trimnell, Yongzhong Wu, Keith Lowe
  • Publication number: 20160024520
    Abstract: Nucleotide sequences, amino acid sequences, and an associated promoter sequence are useful in methods of controlling male fertility in plants. Recombinant expression cassettes, vectors, plant cells, and plants comprise a disclosed nucleotide sequence and may encode a disclosed amino acid sequence. The recombinant expression cassettes are useful in controlling fertility, especially male fertility of annual crops. The promoter is useful in driving expression of an operably-linked heterologous polynucleotide. Constructs comprising homology to the promoter sequence are useful for downregulation of a polynucleotide associated with the promoter.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Inventors: Marc C. Albertsen, TIM FOX, APRIL LEONARD, BAILIN LI, BRIAN LOVELAND, MARY TRIMNELL
  • Publication number: 20150167013
    Abstract: Genetic male sterile plants are provided in which complementing constructs result in suppression of a parental phenotype in the progeny. Methods to generate and maintain such plants and methods of use of said plants, are provided, including use of parental plants to produce sterile plants for hybrid seed production.
    Type: Application
    Filed: March 12, 2013
    Publication date: June 18, 2015
    Inventors: Tim Fox, Dale F. Loussaert, Jeffery Schussler, Juan Pablo San Martin Toloza, Bo Shen
  • Publication number: 20150152429
    Abstract: A nuclear maize gene is mutated to result in dominant male sterility. Two mutants are provided which impact signal peptide processing. Restoration constructs and methods are provided for use of the dominant male-sterile mutants in producing hybrid seed for male-sterile hybrid plants. Other signal-peptide modifications are provided. Orthologs of the wild type or mutated gene in various species are provided.
    Type: Application
    Filed: March 12, 2013
    Publication date: June 4, 2015
    Inventors: Marc Albertsen, Tim Fox, April Leonard, Bailin Li, Brian Loveland, Mary Trimnell
  • Publication number: 20150067913
    Abstract: Pairs of plants are provided in which complementing constructs result in suppression of a parental phenotype in the progeny. Methods to generate and maintain such plants and methods of use of said plants, are provided, including use of parental plants to produce sterile plants for hybrid seed production. Also provided are methods for maintaining a homozygous recessive condition and for repressing transmission of transgenes.
    Type: Application
    Filed: November 17, 2014
    Publication date: March 5, 2015
    Inventors: Tim Fox, Howard P Hershey, Yongzhong Wu, Andrew Cigan, Erica Unger-Wallace
  • Patent number: 8965071
    Abstract: Systems, methods and computer program products identify first biologic data in a region of interest in a first image and calculate a first biologic volume histogram from the first biologic data. Second biologic data in the same region of interest is identified in a second image and a second biologic volume histogram is calculated from the second biologic data. A difference in intensity for the region of interest is determined using the first biologic volume histogram and the second biologic volume histogram.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: February 24, 2015
    Assignee: Emory University
    Inventors: Tim Fox, Ian Crocker, Paul Pantalone, Eduard Schreibmann
  • Patent number: 8927805
    Abstract: Nucleotide sequences of a Msca1 gene, critical to male fertility in plants are described, with DNA molecule and amino acid sequences set forth. Promoter sequences and their essential regions are also identified. The nucleotide sequences are useful in impacting male fertility in plants.
    Type: Grant
    Filed: February 22, 2011
    Date of Patent: January 6, 2015
    Assignees: Pioneer Hi Bred International Inc, E I du Pont de Nemours and Company
    Inventors: Marc C. Albertsen, Tim Fox, Mary Trimnell, Yongzhong Wu, Keith Lowe