Patents by Inventor Tim Geiser
Tim Geiser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240018190Abstract: In various embodiments, a synthetic peptide finding use as a molecular wire in a molecular electronic circuit comprises an alpha helical segment further comprising repeating alpha-helical motifs. The synthetic peptide may further comprise at least one specific conjugation site between the termini for attachment to a molecule such as a binding probe, and may further comprise termini having metal binding functionality such as repeats of material binding sequences. In various aspects, the synthetic peptide comprises intramolecular hydrogen bonding, salt bridges, and optionally, aromatic rings that provide for electrical conductivity through the peptide.Type: ApplicationFiled: January 10, 2020Publication date: January 18, 2024Applicant: Roswell Biotechnologies, Inc.Inventors: Barry Merriman, Tim Geiser, Venkatesh Alagarswarmy Govindaraj
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Publication number: 20230321625Abstract: Systems and methods for polynucleotide synthesis utilize electrochemical deprotection and novel redox chemistries compatible with advanced CMOS nodes, for highly reliable and massively scalable parallel construction of polynucleotide segments having a desired sequence or sequences. Via use of these exemplary techniques, low-cost and large-scale polynucleotide synthesis is facilitated, for example for data storage and retrieval applications.Type: ApplicationFiled: February 16, 2023Publication date: October 12, 2023Inventors: Barry Merriman, Ryan de Ridder, Matthew T. Holden, Tim Geiser
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Patent number: 11724244Abstract: Systems and methods for polynucleotide synthesis utilize electrochemical deprotection and novel redox chemistries compatible with advanced CMOS nodes, for highly reliable and massively scalable parallel construction of polynucleotide segments having a desired sequence or sequences. Via use of these exemplary techniques, low-cost and large-scale polynucleotide synthesis is facilitated, for example for data storage and retrieval applications.Type: GrantFiled: April 13, 2022Date of Patent: August 15, 2023Assignee: Avery Digital Data, Inc.Inventors: Barry Merriman, Ryan de Ridder, Matthew T. Holden, Tim Geiser
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Patent number: 11656197Abstract: A sequencing device is disclosed. The sequence device includes an array of conducting electrode pairs, each pair of electrodes comprising a source and a drain electrode arrangement separated by a nanogap, the electrode array deposited and patterned on a dielectric substrate; at least one transition metal dichalcogenide (TMD) layer disposed on each pair of electrodes, wherein the TMD layer connects each source and drain electrode within each pair, and bridges each nanogap of each pair of electrodes; and a dielectric masking layer disposed on the TMD layer and comprising at least one opening that defines an exposed TMD region, wherein the at least one opening is sized so as to allow a single biomolecule to fit therein and to attach on to the exposed TMD region. In embodiments of the disclosure, the TMD layer be a defective TMD layer.Type: GrantFiled: November 22, 2017Date of Patent: May 23, 2023Assignee: Roswell ME Inc.Inventors: Chulmin Choi, Sungho Jin, Barry L. Merriman, Paul Mola, Tim Geiser
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Publication number: 20220390407Abstract: A processive enzyme molecular sensor for use in a DNA data storage system is disclosed that can extract digital information suitably encoded into a synthetic DNA molecule. In various aspects, such sensors are provided in a high-density chip-based format that can provide the high throughput, low-cost and fast data extraction capability required for large scale DNA data storage systems. The sensor for reading the digital data stored in DNA molecules processes individual encoded DNA molecules directly, eliminating the need for complicated sample preparation such as making copies of DNA or clonal populations of such molecules.Type: ApplicationFiled: June 13, 2022Publication date: December 8, 2022Applicant: Roswell Biotechnologies, Inc.Inventors: Barry Merriman, Paul W. Mola, Tim Geiser, Gina Costa
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Publication number: 20220299467Abstract: A structure usable in a molecular sensor device comprises a substrate defining a substrate plane and spaced apart pairs of reducible metal oxide or metal nitride sheets attached to the substrate at an angle to the substrate plane. The structure further includes intervening dielectric sheets. Fabrication methods for manufacturing structures for molecular sensors are disclosed comprising oblique angle deposition of reducible metal oxide or metal nitride and dielectric layers, planarization of the resulting stack, and reduction of portions of the reducible metal oxide or metal nitride sheets to the corresponding base metal.Type: ApplicationFiled: August 18, 2020Publication date: September 22, 2022Applicant: Roswell Biotechnologies, Inc.Inventors: Sungho Jin, Barry Merriman, Tim Geiser, Paul W. Mola
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Publication number: 20220280906Abstract: Systems and methods for polynucleotide synthesis utilize electrochemical deprotection and novel redox chemistries compatible with advanced CMOS nodes, for highly reliable and massively scalable parallel construction of polynucleotide segments having a desired sequence or sequences. Via use of these exemplary techniques, low-cost and large-scale polynucleotide synthesis is facilitated, for example for data storage and retrieval applications.Type: ApplicationFiled: April 13, 2022Publication date: September 8, 2022Applicant: Avery Digital Data, Inc.Inventors: Barry Merriman, Ryan de Ridder, Matthew T. Holden, Tim Geiser
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Patent number: 11371955Abstract: A processive enzyme molecular sensor for use in a DNA data storage system is disclosed that can extract digital information suitably encoded into a synthetic DNA molecule. In various aspects, such sensors are provided in a high-density chip-based format that can provide the high throughput, low-cost and fast data extraction capability required for large scale DNA data storage systems. The sensor for reading the digital data stored in DNA molecules processes individual encoded DNA molecules directly, eliminating the need for complicated sample preparation such as making copies of DNA or clonal populations of such molecules.Type: GrantFiled: August 30, 2018Date of Patent: June 28, 2022Assignee: ROSWELL BIOTECHNOLOGIES, INC.Inventors: Barry Merriman, Tim Geiser, Paul Mola, Gina Costa
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Publication number: 20220154241Abstract: In various embodiments a molecular circuit is disclosed. The circuit comprises a negative electrode, a positive electrode spaced apart from the negative electrode, and an enzyme molecule conductively attached to both the positive and negative electrodes to form a circuit having a conduction pathway through the enzyme. In various examples, the enzyme is a polymerase. The circuit may further comprise molecular arms used to wire the enzyme to the electrodes. In various embodiments, the circuit functions as a sensor, wherein electrical signals, such as changes to voltage, current, impedance, conductance, or resistance in the circuit, are measured as substrates interact with the enzyme.Type: ApplicationFiled: January 27, 2022Publication date: May 19, 2022Applicant: Roswell Biotechnologies, Inc.Inventors: Barry Merriman, Venkatesh Alagarswamy Govindaraj, Paul Mola, Tim Geiser
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Publication number: 20220148682Abstract: In various embodiments, amplification-free DNA information methods, apparatus and systems are disclosed. A method of amplification-free information storage and retrieval comprises encoding digital data such as binary into nucleotide sequence motifs using an encoding scheme, and synthesizing replicate DNA molecules using an amplification-free DNA writing process. The amplification-free process of decoding the information stored in the DNA comprises exposing at least one of the replicate DNA molecules to a molecular electronics sensor that generates distinguishable signals in a measured electrical parameter of the sensor, wherein the distinguishable signals correspond to the sequence motifs, providing decoding back to the digital data.Type: ApplicationFiled: July 13, 2021Publication date: May 12, 2022Applicant: Roswell Biotechnologies, Inc.Inventors: Barry Merriman, Tim Geiser, Paul Mola, Gina Costa
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Patent number: 11268123Abstract: In various embodiments a molecular circuit is disclosed. The circuit comprises a negative electrode, a positive electrode spaced apart from the negative electrode, and an enzyme molecule conductively attached to both the positive and negative electrodes to form a circuit having a conduction pathway through the enzyme. In various examples, the enzyme is a polymerase. The circuit may further comprise molecular arms used to wire the enzyme to the electrodes. In various embodiments, the circuit functions as a sensor, wherein electrical signals, such as changes to voltage, current, impedance, conductance, or resistance in the circuit, are measured as substrates interact with the enzyme.Type: GrantFiled: November 14, 2019Date of Patent: March 8, 2022Assignee: Roswell Biotechnologies, Inc.Inventors: Barry L. Merriman, Venkatesh Alagarswamy Govindaraj, Paul Mola, Tim Geiser
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Publication number: 20220018798Abstract: In various embodiments a molecular circuit is disclosed. The circuit comprises a negative electrode, a positive electrode spaced apart from the negative electrode, and a binding probe molecule conductively attached to both the positive and negative electrodes to form a circuit having a conduction pathway through the binding probe. In various examples, the binding probe is an antibody, the Fab domain of an antibody, a protein, a nucleic acid oligomer hybridization probe, or an aptamer. The circuit may further comprise molecular arms used to wire the binding probe to the electrodes. In various embodiments, the circuit functions as a sensor wherein electrical signals, such as changes to voltage, current, impedance, conductance, or resistance in the circuit, are measured as targets interact with the binding probe. In various embodiments, the circuit provides a means to measure the presence, absence, or concentration of an analyte in a solution.Type: ApplicationFiled: September 23, 2021Publication date: January 20, 2022Applicant: Roswell Biotechnologies, Inc.Inventors: Barry Merriman, Venkatesh Alagarswamy Govindaraj, Paul W. Mola, Tim Geiser, Gina Costa
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Publication number: 20220002777Abstract: In various embodiments a molecular circuit is disclosed. The circuit comprises a negative electrode, a positive electrode spaced apart from the negative electrode, and an enzyme molecule conductively attached to both the positive and negative electrodes to form a circuit having a conduction pathway through the enzyme. In various examples, the enzyme is a polymerase. The circuit may further comprise molecular arms used to wire the enzyme to the electrodes. In various embodiments, the circuit functions as a sensor, wherein electrical signals, such as changes to voltage, current, impedance, conductance, or resistance in the circuit, are measured as substrates interact with the enzyme.Type: ApplicationFiled: December 30, 2020Publication date: January 6, 2022Applicant: Roswell Biotechnologies, Inc.Inventors: Barry L. Merriman, Venkatesh Alagarswamy Govindaraj, Paul Mola, Tim Geiser
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Patent number: 11143617Abstract: In various embodiments a molecular circuit is disclosed. The circuit comprises a negative electrode, a positive electrode spaced apart from the negative electrode, and a binding probe molecule conductively attached to both the positive and negative electrodes to form a circuit having a conduction pathway through the binding probe. In various examples, the binding probe is an antibody, the Fab domain of an antibody, a protein, a nucleic acid oligomer hybridization probe, or an aptamer. The circuit may further comprise molecular arms used to wire the binding probe to the electrodes. In various embodiments, the circuit functions as a sensor wherein electrical signals, such as changes to voltage, current, impedance, conductance, or resistance in the circuit, are measured as targets interact with the binding probe. In various embodiments, the circuit provides a means to measure the presence, absence, or concentration of an analyte in a solution.Type: GrantFiled: March 26, 2020Date of Patent: October 12, 2021Assignee: ROSWELL BIOTECHNOLOGIES, INC.Inventors: Barry L. Merriman, Venkatesh Alagarswamy Govindaraj, Paul Mola, Tim Geiser, Gina Costa
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Patent number: 11100404Abstract: In various embodiments, amplification-free DNA information methods, apparatus and systems are disclosed. A method of amplification-free information storage and retrieval comprises encoding digital data such as binary into nucleotide sequence motifs using an encoding scheme, and synthesizing replicate DNA molecules using an amplification-free DNA writing process. The amplification-free process of decoding the information stored in the DNA comprises exposing at least one of the replicate DNA molecules to a molecular electronics sensor that generates distinguishable signals in a measured electrical parameter of the sensor, wherein the distinguishable signals correspond to the sequence motifs, providing decoding back to the digital data.Type: GrantFiled: October 10, 2018Date of Patent: August 24, 2021Assignee: Roswell Biotechnologies, Inc.Inventors: Barry Merriman, Tim Geiser, Paul Mola, Gina Costa
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Publication number: 20210225461Abstract: In various embodiments, an information storage system comprises: a writing device for synthesizing a nucleotide sequence that encodes a set of information; and a reading device for interpreting the nucleotide sequence by decoding the interpreted nucleotide sequence into the set of information, wherein the reading device comprises a molecular electronics sensor, the sensor comprising a pair of spaced apart electrodes and a molecular complex attached to each electrode to form a molecular electronics circuit, wherein the molecular complex comprises a bridge molecule and a probe molecule, and wherein the molecular electronics sensor produces distinguishable signals in a measurable electrical parameter of the molecular electronics sensor, when interpreting the nucleotide sequence.Type: ApplicationFiled: November 30, 2020Publication date: July 22, 2021Applicant: Roswell Biotechnologies, Inc.Inventors: Barry L. Merriman, Tim Geiser, Paul Mola
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Publication number: 20210139959Abstract: In various embodiments, a signal enhancement process for single molecule molecular sensors is disclosed along with new modified dNTPs. In general, the enhancement process comprises providing a molecular electronic sensor comprising a polymerase and providing a nucleotide template and modified dNTPs in appropriate buffers to the polymerase, wherein incorporation of the modified dNTPs during action of the polymerase enzyme provides an enhanced electrical signal or improved signal-to-noise ratio for the incorporation event relative to the performance with corresponding native dNTPs.Type: ApplicationFiled: August 1, 2017Publication date: May 13, 2021Inventors: Barry L. Merriman, Tim Geiser, Paul W. Mola, Darryl Rideout
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Publication number: 20210048405Abstract: In various embodiments a molecular circuit is disclosed. The circuit comprises a negative electrode, a positive electrode spaced apart from the negative electrode, and a binding probe molecule conductively attached to both the positive and negative electrodes to form a circuit having a conduction pathway through the binding probe. In various examples, the binding probe is an antibody, the Fab domain of an antibody, a protein, a nucleic acid oligomer hybridization probe, or an aptamer. The circuit may further comprise molecular arms used to wire the binding probe to the electrodes. In various embodiments, the circuit functions as a sensor wherein electrical signals, such as changes to voltage, current, impedance, conductance, or resistance in the circuit, are measured as targets interact with the binding probe. In various embodiments, the circuit provides a means to measure the presence, absence, or concentration of an analyte in a solution.Type: ApplicationFiled: March 26, 2020Publication date: February 18, 2021Applicant: Roswell Biotechnologies, IncInventors: Barry L. Merriman, Venkatesh Alagarswamy Govindaraj, Paul Mola, Tim Geiser, Gina Costa
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Patent number: 10913966Abstract: In various embodiments a molecular circuit is disclosed. The circuit comprises a negative electrode, a positive electrode spaced apart from the negative electrode, and an enzyme molecule conductively attached to both the positive and negative electrodes to form a circuit having a conduction pathway through the enzyme. In various examples, the enzyme is a polymerase. The circuit may further comprise molecular arms used to wire the enzyme to the electrodes. In various embodiments, the circuit functions as a sensor, wherein electrical signals, such as changes to voltage, current, impedance, conductance, or resistance in the circuit, are measured as substrates interact with the enzyme.Type: GrantFiled: May 19, 2020Date of Patent: February 9, 2021Assignee: Roswell Biotechnologies, Inc.Inventors: Barry L. Merriman, Venkatesh Alagarswamy Govindaraj, Paul Mola, Tim Geiser
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Patent number: 10902939Abstract: In various embodiments, an information storage system comprises: a writing device for synthesizing a nucleotide sequence that encodes a set of information; and a reading device for interpreting the nucleotide sequence by decoding the interpreted nucleotide sequence into the set of information, wherein the reading device comprises a molecular electronics sensor, the sensor comprising a pair of spaced apart electrodes and a molecular complex attached to each electrode to form a molecular electronics circuit, wherein the molecular complex comprises a bridge molecule and a probe molecule, and wherein the molecular electronics sensor produces distinguishable signals in a measurable electrical parameter of the molecular electronics sensor, when interpreting the nucleotide sequence.Type: GrantFiled: January 10, 2018Date of Patent: January 26, 2021Assignee: Roswell Biotechnologies, Inc.Inventors: Barry L. Merriman, Tim Geiser, Paul Mola