Abstract: The invention is in the field of medical treatments, in particular the treatment of humans, more in particular humans with calcium deposition diseases. In one aspect, the invention provides polypeptides that prevent or decrease the precipitation of calcium crystals in the human body, also known as ectopic calcification. More in particular, the invention relates to a circular polypeptide consisting of an amino acid sequence according to SEQ ID NO: 1, wherein the amino acids are D-amino acids, pharmaceutical compositions comprising a polypeptide as described herein and their use in the treatment of a disease selected from the group consisting of osteoarthritis, frozen shoulder syndrome, heterotopic ossification, vascular calcification, kidney stones and calcinosis.

Abstract: The present invention is in the field of medicine and provides means and methods for the treatment, prevention or amelioration of osteoarthritis. More in particular, it provides a peptide for use in the treatment, amelioration or prevention of osteoarthritis, wherein the peptide is between 12 and 28 amino acids in length and comprises an amino acid sequence according to SEQ ID NO: 16 or a variant thereof according to formula 2, wherein the amino acid sequence of said peptide is comprised in SEQ ID NO: 34 or a variant thereof according to formula 1.

Abstract: There is provided a wheel system for a vehicle, the wheel system comprises a stator, a rotor, a rotational bearing and an inwheel motor. The inwheel motor comprises a motor stator and a motor rotor. The rotor is coupled to the stator via the rotational bearing to rotate about a rotational axis. The motor stator is connected to the stator. The motor rotor is connected to the rotor to cooperate with the motor stator to generate an electromagnetic force to rotate the rotor relative to the stator about the rotational axis. The motor stator has a center defining a central plane extending through the center and perpendicular to the rotational axis. The central plane has an inboard side and an outboard side. In operational use, the inboard side faces toward a center of the vehicle, and the outboard side faces away from the center of the vehicle. The rotor has a mounting surface configured to be connected to a wheel rim. The mounting surface is arranged on the inboard side.

Abstract: The present invention is in the field of medicine and provides means and methods for the treatment, prevention or amelioration of osteoarthritis. More in particular, it provides a peptide for use in the treatment, amelioration or prevention of osteoarthritis, wherein the peptide is between 12 and 28 amino acids in length and comprises an amino acid sequence according to SEQ ID NO: 16 or a variant thereof according to formula 2, wherein the amino acid sequence of said peptide is comprised in SEQ ID NO: 34 or a variant thereof according to formula 1.

Abstract: The present invention is in the field of medicine and provides means and methods for the treatment, prevention or amelioration of osteoarthritis. More in particular, it provides a peptide for use in the treatment, amelioration or prevention of osteoarthritis, wherein the peptide consists of an amino acid sequence according to SEQ ID NO: 18 or an analogue thereof, wherein the analogue is a peptide consisting of an amino acid sequence according to formula 1 (SEQ ID NO: 29), or a fragment thereof wherein the fragment consists of at least 10 consecutive amino acids of SEQ ID NO: 18 or an amino acid sequence according to formula 1.

Abstract: The present invention is in the field of medicine and provides means and methods for the treatment, prevention or amelioration of osteoarthritis. More in particular, it provides a peptide for use in the treatment, amelioration or prevention of osteoarthritis, wherein the peptide is between 12 and 28 amino acids in length and comprises an amino acid sequence according to SEQ ID NO: 16 or a variant thereof according to formula 2, wherein the amino acid sequence of said peptide is comprised in SEQ ID NO: 34 or a variant thereof according to formula 1.

Abstract: The present invention is in the field of medicine and provides means and methods for the treatment, prevention or amelioration of osteoarthritis. More in particular, it provides a peptide for use in the treatment, amelioration or prevention of osteoarthritis, wherein the peptide is between 12 and 28 amino acids in length and comprises an amino acid sequence according to SEQ ID NO: 16 or a variant thereof according to formula 2, wherein the amino acid sequence of said peptide is comprised in SEQ ID NO: 34 or a variant thereof according to formula 1.

Abstract: The present invention is in the field of medicine and provides means and methods for the treatment, prevention or amelioration of osteoarthritis. More in particular, it provides a peptide for use in the treatment, amelioration or prevention of osteoarthritis, wherein the peptide consists of an amino acid sequence according to SEQ ID NO: 18 or an analogue thereof, wherein the analogue is a peptide consisting of an amino acid sequence according to formula 1 (SEQ ID NO: 29), or a fragment thereof wherein the fragment consists of at least 10 consecutive amino acids of SEQ ID NO: 18 or an amino acid sequence according to formula 1.

Abstract: The present invention is in the field of medicine and provides means and methods for the treatment, prevention or amelioration of osteoarthritis. More in particular, it provides a peptide for use in the treatment, amelioration or prevention of osteoarthritis, wherein the peptide consists of an amino acid sequence according to SEQ ID NO: 18 or an analogue thereof, wherein the analogue is a peptide consisting of an amino acid sequence according to formula 1 (SEQ ID NO: 29), or a fragment thereof wherein the fragment consists of at least 10 consecutive amino acids of SEQ ID NO: 18 or an amino acid sequence according to formula 1.

Abstract: The present invention is in the field of medicine and provides means and methods for the treatment, prevention or amelioration of osteoarthritis. More in particular, it provides a peptide for use in the treatment, amelioration or prevention of osteoarthritis, wherein the peptide is between 12 and 28 amino acids in length and comprises an amino acid sequence according to SEQ ID NO: 16 or a variant thereof according to formula 2, wherein the amino acid sequence of said peptide is comprised in SEQ ID NO: 34 or a variant thereof according to formula 1.

Abstract: The present invention relates to a system and method for assessing the cognitive style of a person. The system comprises an input interface (12) for receiving speech spoken by the person, a language processor (16) for analyzing the speech to identify predetermined natural language elements, and a style identifier (18, 18?) for identifying the cognitive style of the person based on the identified natural language elements.

Abstract: The present invention is in the field of medicine and provides means and methods for the treatment, prevention or amelioration of osteoarthritis. More in particular, it provides a peptide for use in the treatment, amelioration or prevention of osteoarthritis, wherein the peptide consists of an amino acid sequence according to SEQ ID NO: 18 or an analogue thereof, wherein the analogue is a peptide consisting of an amino acid sequence according to formula 1 (SEQ ID NO: 29), or a fragment thereof wherein the fragment consists of at least 10 consecutive amino acids of SEQ ID NO: 18 or an amino acid sequence according to formula 1.

Abstract: The present invention is in the field of medicine and provides means and methods for the treatment, prevention or amelioration of osteoarthritis. More in particular, it provides a peptide for use in the treatment, amelioration or prevention of osteoarthritis, wherein the peptide is between 12 and 28 amino acids in length and comprises an amino acid sequence according to SEQ ID NO: 16 or a variant thereof according to formula 2, wherein the amino acid sequence of said peptide is comprised in SEQ ID NO: 34 or a variant thereof according to formula 1.

Abstract: The present invention relates to a device (1) for vital sign measurement of a person (2), comprising presentation means (10) for presenting a person (2) with a visual theme (20), illumination means (11) for illuminating an illumination area (3), in which said person (2) is located, whose vital signs shall be measured, optical measurement means (12) for optically detecting optical detection signals (23) from said illumination area (3), evaluation means (13) for evaluating said optical detection signals (23) and deriving a vital sign information (24) from them, and control means (14) for controlling said illumination means (11) to illuminate said illumination area (3) allowing the detection of optical detection signals (23), from which a vital sign information (24) can be derived despite changes of the visual theme (20).

Abstract: A system and method for radiotherapeutic treatment of a patient (20) are provided. The system comprises a patient carrier (11) for receiving the patient (20), means for monitoring (12) positions of at least two different body parts of the patient (20), a processor (14) and feedback means (13). The processor (14) is coupled to the means for monitoring (12) positions and is operative to analyze the monitored positions to determine, for each body part of the at least two body parts, a displacement of the respective body part with respect to a particular desired position. The feedback means (13) are coupled to the processor (14) for interacting with the patient (20) and to provide feedback concerning the displacement of the respective body part.

Abstract: A breath pacing apparatus and a method for pacing a respiration of a person include a haptic output unit with a variable haptically perceivable feature. The haptic output unit is configured to change the haptically perceivable feature periodically according to a sequence of desired respiration cycles, where a characteristic of the change of the haptically perceivable feature is related to a length of the respiration cycles in the sequence of desired respiration cycles.

Abstract: A method of controlling an influence on a user in a rendering environment includes obtaining signal data representing one or more physiological conditions of a user in response to an influence caused by system feedback of the rendering environment; obtaining data corresponding to a user's desired emotional state, which data is based on the user's self-reports and data representative of accompanying signal data representing one or more physiological conditions of the user over a last period before the accompanying self-report; determining whether the desired emotional state is reached; and if the state is not reached, adapting the system feedback provided by the rendering environment correspondingly.

Abstract: An apparatus for providing a patterned structure includes a deposition facility for depositing an electrically conductive material on a cylindrical surface of a transfer roll, a supply facility for providing a flexible substrate with a carrier layer, a press-roll for pressing the flexible substrate with the carrier layer against the surface of the transfer roll, the press-roll being positioned in the rotation direction of the transfer roll with respect to a position where the first deposition facility deposits the substance on the transfer roll, and being arranged for embedding the deposited substance in said carrier layer, wherein the adhesion between the printed substance and the cylindrical surface of the transfer roll is less than the adhesion between the printed substance and said carrier layer, a transport facility for releasing the flexible substrate with the carrier layer embedding the substance as the patterned structure from the transfer roll.

Abstract: A system and a method include a display configured to display video and/or still images, and an image source that is in communication with the display and configured to allow content of the image source to be displayed on the display. Further, the system and method include a physiological information gatherer configured to obtain a current physiological information of a patient when the patient is positioned to see the video and/or still image on the display. A processor is configured to receive the current physiological information from the physiological information gatherer, and the processor, being in communication with the image source, is further configured to transmit to the display the current physiological information and a target breathing rate.