Abstract: The present disclosure provides bifunctional compounds of Formula (I), and pharmaceutically acceptable salts, isotopic forms, isolated stereoisomers, or mixtures of stereoisomers thereof, as IRAK4 degraders via ubiquitin proteasome pathway, and method for treating diseases modulated by IRAK4.

Abstract: The present disclosure provides bifunctional compounds as IRAK4 degraders via ubiquitin proteasome pathway, and method for treating diseases modulated by IRAK4.

Abstract: In an example embodiment, a system and method to store and retrieve application data from a cache and a database are provided. The example method may comprise receiving location data associated with application data from a user device, using the location data to determine a cache or database on which the application data is stored, and requesting application data from the cache or database. The system and method may further include monitoring requests for application data associated with instructions having a set of characteristics, identifying application data as associated with the instructions having the set of characteristics, and requesting the application data based on receiving subsequent instructions sharing the same set of characteristics.

Abstract: In an example embodiment, a system and method to store and retrieve application data from a cache and a database are provided. The example method may comprise receiving location data associated with application data from a user device, using the location data to determine a cache or database on which the application data is stored, and requesting application data from the cache or database. The system and method may further include monitoring requests for application data associated with instructions having a set of characteristics, identifying application data as associated with the instructions having the set of characteristics, and requesting the application data based on receiving subsequent instructions sharing the same set of characteristics.

Abstract: In an example embodiment, a system and method to store and retrieve application data from a database are provided. In an example embodiment, location data comprising a database identifier is received. A location of a database is derived based on the database identifier, the database being one of a plurality of databases, each database of the plurality of databases comprising application data, and application data is requested from the database based on the derived location.

Abstract: In an example embodiment, a system and method to store and retrieve application data from a database are provided. In an example embodiment, location data comprising a database identifier is received. A location of a database is derived based on the database identifier, the database being one of a plurality of databases, each database of the plurality of databases comprising application data, and application data is requested from the database based on the derived location.

Abstract: Methods, systems, and apparatus for accessing application data are described. A cookie comprising location data is received from a user device, the location data comprising a cache identifier and a database identifier, the cache identifier identifying a cache of a plurality of caches. A location of the cache of the plurality of caches based on the cache identifier is derived and application data is requested from the cache based on the derived location. In one example embodiment, a determination is made whether the requested application data is not stored in the cache corresponding to the cache identifier and the requested application data is requested from a database of a plurality of databases based on the determination, the database corresponding to the database identifier.

Abstract: In an example embodiment, a system and method to store and retrieve application data from a cache and a database are provided. The example method may comprise receiving location data associated with application data from a user device, using the location data to determine a cache or database on which the application data is stored, and requesting application data from the cache or database. The system and method may further include monitoring requests for application data associated with instructions having a set of characteristics, identifying application data as associated with the instructions having the set of characteristics, and requesting the application data based on receiving subsequent instructions sharing the same set of characteristics.

Abstract: In an example embodiment, a system and method to store and retrieve application data from a cache and a database are provided. The example method may comprise receiving location data associated with application data from a user device, using the location data to determine a cache or database on which the application data is stored, and requesting application data from the cache or database. The system and method may further include monitoring requests for application data associated with instructions having a set of characteristics, identifying application data as associated with the instructions having the set of characteristics, and requesting the application data based on receiving subsequent instructions sharing the same set of characteristics.

Abstract: In an example embodiment, a system and method to store and retrieve application data from a cache and a database are provided. The example method may comprise receiving location data associated with application data from a user device, using the location data to determine a cache or database on which the application data is stored, and requesting application data from the cache or database. The system and method may further include monitoring requests for application data associated with instructions having a set of characteristics, identifying application data as associated with the instructions having the set of characteristics, and requesting the application data based on receiving subsequent instructions sharing the same set of characteristics.