Abstract: The present disclosure provides bifunctional compounds of Formula (I), and pharmaceutically acceptable salts, isotopic forms, isolated stereoisomers, or mixtures of stereoisomers thereof, as IRAK4 degraders via ubiquitin proteasome pathway, and method for treating diseases modulated by IRAK4.

Abstract: We disclose herein a flow sensor comprising: a first substrate comprising an etched portion, a dielectric region located on a first side of the first substrate, wherein the dielectric region comprises at least one dielectric membrane located over the etched portion of the first substrate, a sensing element located on or within the dielectric membrane, and a second substrate adjoining a second side of the first substrate. The first side of the first substrate and the second side of the first substrate are opposite sides. The first substrate and the second substrate cooperate to form a sensing channel through the flow sensor.

Abstract: Apparatus for binning an input value into one of a plurality of bins which collectively represent a histogram of input values, each of the plurality of bins representing a corresponding range of input values, the apparatus comprising: an input for receiving an input value; a noise source configured to generate an error value according to a predetermined noise distribution; and a binning controller configured to mix the received input value with the error value so as to generate a modified input value and to allocate the modified input value to the bin corresponding to that modified input value.

Abstract: The example embodiments relate to matching response data to request data. in an embodiment, a method includes retrieving a request and a plurality of responses; generating packed candidates based on the request and the plurality of responses, a given packed candidate in the packed candidates including the request and a subset of the plurality of responses; generating feature vectors corresponding to the packed candidates, a given feature vector in the feature vectors including at least one aggregated feature computed based on the request and one or more corresponding responses in a respective packed candidate; inputting the feature vectors into a machine learning (ML) model, the ML model configured to output predictions corresponding to the feature vectors; selecting a feature vector from the feature vectors based on the predictions; and storing responses associated with the optimal feature vector and the request in a data storage device.

Abstract: Apparatus for binning an input value into one of a plurality of bins which collectively represent a histogram of input values, each of the plurality of bins representing a corresponding range of input values, the apparatus comprising: an input for receiving an input value; a noise source configured to generate an error value according to a predetermined noise distribution; and a binning controller configured to mix the received input value with the error value so as to generate a modified input value and to allocate the modified input value to the bin corresponding to that modified input value.

Abstract: Apparatus for binning an input value into one of a plurality of bins which collectively represent a histogram of input values, each of the plurality of bins representing a corresponding range of input values, the apparatus comprising: an input for receiving an input value; a noise source configured to generate an error value according to a predetermined noise distribution; and a binning controller configured to mix the received input value with the error value so as to generate a modified input value and to allocate the modified input value to the bin corresponding to that modified input value.

Abstract: An apparatus for use to apply a liner to an appendage of a user includes a base member and a plurality of arms mounted to the base member. Each arm can include a rotating member, such as a roller ball, coupled to a top end of the arm. The plurality of arms can extend from the base member in a generally upright position and can support the liner thereon in an inside out position so that the application of downward pressure by the appendage of the user within the plurality of arms permits the arms to flex outward, thereby allowing the plurality of arms and roller balls to slide the liner around the appendage of the user. The height of the apparatus can be adjustable by forming each arm in two or more pieces having a height-adjustable engagement between the pieces. Such a configuration further allows for compact disassembly.

Abstract: A liner to an appendage of a user includes a base member, a bracket adjustably mounted to the base member to a desired height position, and a plurality of arms pivotably mounted to the bracket. Each arm can include a rotating member, such as a roller ball, coupled to a top end of the arm. The plurality of arms can extend from the bracket in a generally upright position and can support the liner thereon in an inside out position so that the application of downward pressure by the appendage of the user within the plurality of arms permits the arms to pivot outward, thereby allowing the plurality of arms and roller balls to slide the liner around the appendage of the user.

Abstract: A liner to an appendage of a user includes a base member, a bracket adjustably mounted to the base member to a desired height position, and a plurality of arms pivotably mounted to the bracket. Each arm can include a rotating member, such as a roller ball, coupled to a top end of the arm. The plurality of arms can extend from the bracket in a generally upright position and can support the liner thereon in an inside out position so that the application of downward pressure by the appendage of the user within the plurality of arms permits the arms to pivot outward, thereby allowing the plurality of arms and roller balls to slide the liner around the appendage of the user.

Abstract: Apparatus for binning an input value into one of a plurality of bins which collectively represent a histogram of input values, each of the plurality of bins representing a corresponding range of input values, the apparatus comprising: an input for receiving an input value; a noise source configured to generate an error value according to a predetermined noise distribution; and a binning controller configured to mix the received input value with the error value so as to generate a modified input value and to allocate the modified input value to the bin corresponding to that modified input value.

Abstract: Apparatus for binning an input value into one of a plurality of bins which collectively represent a histogram of input values, each of the plurality of bins representing a corresponding range of input values, the apparatus comprising: an input for receiving an input value; a noise source configured to generate an error value according to a predetermined noise distribution; and a binning controller configured to mix the received input value with the error value so as to generate a modified input value and to allocate the modified input value to the bin corresponding to that modified input value.

Abstract: A binary logic circuit for approximating a mathematical function over a predefined range as a series of linear segments, each linear segment having one of a predetermined set of fixed gradients and a corresponding base value, the binary logic circuit comprising: an input for receiving an input variable in the predefined range; a plurality of logic chains each comprising: a binary multiplier adapted to perform multiplication by a respective one of the set of fixed gradients using h?1 binary adders, where h is the extended Hamming weight; and a binary adder adapted to add a base value to the input or output of the binary multiplier; and selection logic configured to select one of the logic chains in dependence on the input variable so as to provide, for the received input variable, an approximate value of the mathematical function.

Abstract: A binary logic circuit for approximating a mathematical function over a predefined range as a series of linear segments, each linear segment having one of a predetermined set of fixed gradients and a corresponding base value, the binary logic circuit comprising: an input for receiving an input variable in the predefined range; a plurality of logic chains each comprising: a binary multiplier adapted to perform multiplication by a respective one of the set of fixed gradients using h?1 binary adders, where h is the extended Hamming weight; and a binary adder adapted to add a base value to the input or output of the binary multiplier; and selection logic configured to select one of the logic chains in dependence on the input variable so as to provide, for the received input variable, an approximate value of the mathematical function.

Abstract: A binary logic circuit for approximating a mathematical function over a predefined range as a series of linear segments, each linear segment having one of a predetermined set of fixed gradients and a corresponding base value, the binary logic circuit comprising: an input for receiving an input variable in the predefined range; a plurality of logic chains each comprising: a binary multiplier adapted to perform multiplication by a respective one of the set of fixed gradients using h?1 binary adders, where h is the extended Hamming weight; and a binary adder adapted to add a base value to the input or output of the binary multiplier; and selection logic configured to select one of the logic chains in dependence on the input variable so as to provide, for the received input variable, an approximate value of the mathematical function.

Abstract: A binary logic circuit for approximating a mathematical function over a predefined range as a series of linear segments, each linear segment having one of a predetermined set of fixed gradients and a corresponding base value, the binary logic circuit comprising: an input for receiving an input variable in the predefined range; a plurality of logic chains each comprising: a binary multiplier adapted to perform multiplication by a respective one of the set of fixed gradients using h?1 binary adders, where h is the extended Hamming weight; and a binary adder adapted to add a base value to the input or output of the binary multiplier; and selection logic configured to select one of the logic chains in dependence on the input variable so as to provide, for the received input variable, an approximate value of the mathematical function.

Abstract: A binary logic circuit for approximating a mathematical function over a predefined range as a series of linear segments, each linear segment having one of a predetermined set of fixed gradients and a corresponding base value, the binary logic circuit comprising: an input for receiving an input variable in the predefined range; a plurality of logic chains each comprising: a binary multiplier adapted to perform multiplication by a respective one of the set of fixed gradients using h-1 binary adders, where h is the extended Hamming weight; and a binary adder adapted to add a base value to the input or output of the binary multiplier; and selection logic configured to select one of the logic chains in dependence on the input variable so as to provide, for the received input variable, an approximate value of the mathematical function.

Abstract: A binary logic circuit for approximating a mathematical function over a predefined range as a series of linear segments, each linear segment having one of a predetermined set of fixed gradients and a corresponding base value, the binary logic circuit comprising: an input for receiving an input variable in the predefined range; a plurality of logic chains each comprising: a binary multiplier adapted to perform multiplication by a respective one of the set of fixed gradients using h-1 binary adders, where h is the extended Hamming weight; and a binary adder adapted to add a base value to the input or output of the binary multiplier; and selection logic configured to select one of the logic chains in dependence on the input variable so as to provide, for the received input variable, an approximate value of the mathematical function.

Abstract: A binary logic circuit for approximating a mathematical function over a predefined range as a series of linear segments, each linear segment having one of a predetermined set of fixed gradients and a corresponding base value, the binary logic circuit comprising: an input for receiving an input variable in the predefined range; a plurality of logic chains each comprising: a binary multiplier adapted to perform multiplication by a respective one of the set of fixed gradients using h-1 binary adders, where h is the extended Hamming weight; and a binary adder adapted to add a base value to the input or output of the binary multiplier; and selection logic configured to select one of the logic chains in dependence on the input variable so as to provide, for the received input variable, an approximate value of the mathematical function.

Abstract: A binary logic circuit for approximating a mathematical function over a predefined range as a series of linear segments, each linear segment having one of a predetermined set of fixed gradients and a corresponding base value, the binary logic circuit comprising: an input for receiving an input variable in the predefined range; a plurality of logic chains each comprising: a binary multiplier adapted to perform multiplication by a respective one of the set of fixed gradients using h?1 binary adders, where h is the extended Hamming weight; and a binary adder adapted to add a base value to the input or output of the binary multiplier; and selection logic configured to select one of the logic chains in dependence on the input variable so as to provide, for the received input variable, an approximate value of the mathematical function.

Abstract: Apparatus for binning an input value into one of a plurality of bins which collectively represent a histogram of input values, each of the plurality of bins representing a corresponding range of input values, the apparatus comprising: an input for receiving an input value; a noise source configured to generate an error value according to a predetermined noise distribution; and a binning controller configured to mix the received input value with the error value so as to generate a modified input value and to allocate the modified input value to the bin corresponding to that modified input value.