Abstract: A closing device for releasably connecting a first part to a second part. The closing device may have a first closing unit including a spherical engaging part, and a first retaining device for attaching the first part. The closing device also may include a second closing unit which has a second retaining device for attaching the second part, and a cut out, which is delimited by a wall, for receiving the spherical engaging part, where the cut out has an opening for inserting the spherical engaging part. A sliding unit may be located in the cut out, the sliding unit being preloaded in the direction of the opening, and the sliding unit can be displaced into an open position and a closed position. In the open position of the sliding unit, the spherical engaging part may be received in the cut out.

Abstract: Various embodiments of the present technology generally relate to a single monolithic IC to perform simultaneous optogenetic neural inhibition and extracellular electrophysiological recording in-vivo. Some embodiments include a low input capacitance (e.g., 9.7 pF) amplifier particularly tailored for the use of high-impedance electrodes to conduct single neuron extracellular recording integrated with programmable high current drivers for optogenetic stimulation or inhibition on the same IC chip. Some embodiments use a noise model to guide the IC design process to obtain parameters for optimal signal-to-noise ratio. The performance of the IC chip was demonstrated on an anesthetized gerbil expressed with inhibitory optogenetic protein (Halorhodopsin). Spontaneous action potentials from the fifth nerve of the brainstem were recorded by the amplifier and were subsequently inhibited by laser illumination.

Abstract: A closing device for releasably connecting a first part to a second part. The closing device may have a first closing unit comprising a spherical engaging part, and a first retaining device for attaching the first part. The closing device also may comprise a second closing unit which has a second retaining device for attaching the second part, and a cut out, which is delimited by a wall, for receiving the spherical engaging part, where the cut out has an opening for inserting the spherical engaging part. A sliding unit may be located in the cut out, said sliding unit being preloaded in the direction of the opening, and the sliding unit can be displaced into an open position and a closed position. In the open position of the sliding unit, the spherical engaging part may be received in the cut out.

Abstract: Various embodiments of the present technology generally relate to a single monolithic IC to perform simultaneous optogenetic neural inhibition and extracellular electrophysiological recording in-vivo. Some embodiments include a low input capacitance (e.g., 9.7 pF) amplifier particularly tailored for the use of high-impedance electrodes to conduct single neuron extracellular recording integrated with programmable high current drivers for optogenetic stimulation or inhibition on the same IC chip. Some embodiments use a noise model to guide the IC design process to obtain parameters for optimal signal-to-noise ratio. The performance of the IC chip was demonstrated on an anesthetized gerbil expressed with inhibitory optogenetic protein (Halorhodopsin). Spontaneous action potentials from the fifth nerve of the brainstem were recorded by the amplifier and were subsequently inhibited by laser illumination.

Abstract: A multimodal method for imaging tissue comprising: aligning an excitation light source with at least a portion of the tissue; selecting at least two modalities of image acquisition; imaging the tissue portion with each of the modalities of image acquisition; and constructing a dual mode image using images from each of the modalities of image acquisition. A multimodal system for imaging tissue comprising: an excitation light source or light sources; an optical and alignment system for directing the excitation beam or beams to a sample and receiving an emission beam from the sample; at least one detector for receiving the emission beam from the sample; and a spectral filtering or dispersing device for providing at least two imaging modalities at the at least one detector; and a processor for analyzing the detected emission beam and constructing a dual mode image using images from each of the modalities of image acquisition.