Abstract: A crossing guidewire that is adapted for use in crossing an aortic valve may include a proximal shaft segment, a distal shaft segment including a distal end, and a hinge point disposed between the proximal shaft segment and the distal shaft segment. The hinge point may be adapted to allow the distal shaft segment to pivot relative to the proximal shaft segment when the distal end of the distal shaft segment contacts the aortic valve.

Abstract: System for cooled endocardial injection are disclosed. An example system may include a steerable catheter having a first lumen therein. The system may include a cooling circuit disposed along at least a portion of the steerable catheter, the cooling circuit having a fluid inlet, a fluid outlet, a proximal end, and a distal end. The cooling circuit may include a first lumen section extending distally along the steerable catheter and including the fluid inlet and a second lumen section extending proximally along the steerable catheter and including the fluid outlet. The system may include an injection catheter disposed in the first lumen. The injection catheter may be configured to deliver a cooled therapeutic fluid to endocardial tissue.

Abstract: A proximal loader may be used to facilitate loading a prosthetic valve into a catheter. A proximal load may include an elongate body releasably securable about a catheter, the elongate body including a first body half hingedly coupled with a second body half. Each of the first body half and the second body half includes an outer shell, a distal member segment disposed within the outer shell and defining half of a valve crimping region, and a proximal member segment slidingly disposed within the outer shell and defining half of a catheter accepting region.

Abstract: An aortic crossing catheter for directing a crossing wire through the aortic valve may include an outer sheath, an inner sheath slidably disposed within the outer sheath, and an expandable member at least partially fixed to the inner sheath and configured to move between a constrained delivery configuration to a radially expanded deployed configuration. Axial movement of the inner and outer sheaths relative one another radially expands the expandable member such that when a crossing wire is inserted through a lumen of the inner sheath, the wire is directed through the aortic valve.

Abstract: A system for treating mitral regurgitation may include an outer sheath having a lumen extending to a distal end of the outer sheath, an intermediate sheath slidably disposed within the lumen of the outer sheath, the intermediate sheath having a lumen extending to a distal end of the intermediate sheath, and an inner sheath slidably disposed within the lumen of the intermediate sheath, wherein the inner sheath includes a first anchor disposed within a lumen of the inner sheath, the first anchor being configured to penetrate and secure to a first papillary muscle. The intermediate sheath may include a tissue grasping mechanism at the distal end of the intermediate sheath, the tissue grasping mechanism being configured to hold and stabilize the first papillary muscle for penetration and securement of the first anchor to the first papillary muscle.

Abstract: A system for use in replacement heart-valve implant procedures, the system including a guidewire and an elongate member. The elongate member having a side port disposed proximal of a distal tip of the elongate member. The guidewire slideably disposed within a first lumen of the elongate member and configured to be advanced out the side port proximate a leaflet of a native heart valve of a patient. The side port includes an angled wall on the distal end of the port configured such that when the guidewire is advanced out of the side port, it extends out at an angle relative to the elongate member.

Abstract: A replacement heart valve system may include a replacement heart valve implant comprising an expandable framework configured to shift from a radially collapsed configuration to a radially expanded configuration, and a plurality of valve leaflets disposed within and secured to the framework, and an implant delivery system comprising a handle assembly and an elongate shaft assembly extending distally from the handle assembly. The elongate shaft assembly may include an inner shaft axially secured to the handle assembly, an outer tubular member axially secured to the handle assembly and disposed about the inner shaft, and an implant holding portion. The implant holding portion is configured to constrain the implant in the radially collapsed configuration when the implant holding portion is disposed in a delivery configuration, wherein the implant holding portion is rotatable relative to the outer tubular member.

Abstract: A storage board system including a singular, or a set of, corrugated backing members, composed of at least one write erasable outer surface, at least two vertically disposed parallel members mounted to the one, or a set of corrugated backing members, two or more horizontally disposed parallel members mounted in a perpendicular manner to the at least two vertically disposed parallel panels. The horizontally disposed parallel members comprise two or more sets of parallel members attached by a set of two perpendicular joinder members which define a linked set of rectangular areas so as to form a rectangular corrugation. One, or a series of removably attached, multi-purpose, multi-directional hanging devices disposed for attachment to the at least two horizontally disposed corrugated parallel panels including a larger first U-shaped member and a second side comprising a smaller second U-shaped member used in tandem with a self-attaching removably attached bin.

Abstract: System for endocardial injection are disclosed. An example system may include a first steerable catheter having a first lumen formed therein. A second steerable catheter may be disposed within the first lumen. The second steerable catheter may have a second lumen formed therein. An injection catheter may be disposed within the second lumen. The injection catheter may have a distal end region. The distal end region may include an imaging section and a needle section. The system may include an imaging device configured to be disposed within the imaging section.

Abstract: Embodiments herein relate to methods of attaching leaflets to a valve frame and valves made using the same. In an embodiment, a method of making an implantable prosthetic valve is included. The method can include compressing at least a portion of valve leaflet tabs, inserting the compressed valve leaflet tabs into commissural slots of a valve frame, and expanding the compressed valve leaflet tabs. Other embodiments are also included herein.

Abstract: A basilica system for use in replacement heart valve implant procedures may include a first catheter including a side port disposed proximal of a distal tip, a conductive guidewire slidably disposed within the first catheter and configured to be advanced out the side port proximate a leaflet of a replacement heart valve implant disposed within a native heart valve of a patient, a second catheter including a lumen extending to a distal end of the second catheter, and a snare shaft slidably disposed within the second catheter, the snare shaft including a wire loop configured to grasp the conductive guidewire. The basilica system may include a delivery catheter. The first and second catheters may be disposed within the delivery catheter. The conductive guidewire may be configured to be electrically coupled to a source of RF energy. The conductive guidewire may be configured to puncture the leaflet.

Abstract: Certain aspects of the disclosure provide systems and methods for securing and regulating user-AI interactions, an example method comprises receiving, by a message broker of a control platform, a user data prompt to at least one AI system; executing, by a secure layer of the control platform, a security control protocol on the user data prompt; based on the executing, generating, by the secure layer of the control platform, an approved data prompt; providing, via the message broker, the approved data prompt to the at least one AI system; receiving, by the message broker, a response to the approved data prompt from the at least one AI system; and providing, by the secure layer, the response to a user of the control platform.

Abstract: A series of devices that allow for embedding of an image as a background while also affording the user the ability to write and print on the surface, with erasable capabilities, thus providing a multifunctional product for use in numerous industries. The devices are manufactured from predominately corrugated plastic. In one embodiment a one piece, removably attachable, cabinet system and graphic display system. In an additional embodiment, a writable board, or peg board comprising a front panel and a rear panel wherein the panels are interconnected by parallel rows, or corrugations, these panels include a writable and erasable surface. The present invention relates to assemblies of corrugated systems to better serve personal, business, and educational needs.

Abstract: A replacement heart valve implant includes an expandable framework including a commissure post and defining a central lumen, and a valve leaflet disposed within the central lumen, the valve leaflet including a mounting tab secured to the expandable framework at the commissure post. The commissure post is configured to hold the mounting tab in compression. A tool for assembling a replacement heart valve implant includes a tool body comprising first and second body portions, first and second handle portions extending from the body portions, and first and second post engagement arms extending from the body portions. Translation of the first handle portion toward the second handle portion translates the first post engagement arm away from the second post engagement arm.

Abstract: A replacement heart valve system may include a replacement heart valve implant including an expandable framework configured to shift from a radially collapsed to a radially expanded configuration, wherein the framework is self-biased toward the radially expanded configuration, and a plurality of valve leaflets attached to the framework. The replacement heart valve system may include an implant delivery system including a handle and an elongate shaft assembly including a tubular member fixedly attached to the handle, and an implant holding portion configured to constrain the framework in the radially collapsed configuration. The elongate shaft assembly includes an expandable balloon disposed on the tubular member within the implant holding portion, the balloon being configured to shift between deflated and inflated configurations. When the framework is constrained within the implant holding portion, at least a portion of the framework extends distal of the balloon in the deflated configuration.

Abstract: A replacement heart valve system may include a replacement heart valve implant including an expandable framework configured to shift from a radially collapsed configuration to a radially expanded configuration and a plurality of valve leaflets attached to the expandable framework at a plurality of commissure posts, and an implant delivery system including a handle and an elongate shaft assembly, the elongate shaft assembly including a tubular member fixedly attached to the handle, and an implant holding portion configured to constrain the expandable framework in the radially collapsed configuration. The elongate shaft assembly includes an anti-migration element configured to shift between a delivery configuration and an open configuration. The anti-migration element is configured to prevent proximal movement of the expandable framework relative to the tubular member in the open configuration.

Abstract: A mixing valve adapter is disclosed to connect water lines from a mixing valve to a sink faucet. An example of the mixing valve adapter includes an adapter body for connection between the mixing valve and the sink faucet. Valve connections of the adapter body connect to the respective water source connections and the mixing valve. Faucet connections on the adapter body connect to the sink faucet. The faucet connections have reinforcement structures. One of the valve connections also has a reinforcement structure. Connection housings connect the faucet connections to the sink faucet.

Abstract: An implant system and method of delivery includes a catheter system including a sling catheter having a plurality of distal openings and a delivery catheter, disposed within the sling catheter and having a distal port. Suture coupled anchors may be sequentially delivered by the delivery catheter to a cardiac treatment site by aligning the port of the delivery catheter with different openings of the sling catheter and pushing the anchor through the port and the sling catheter to embed the anchor into cardiac tissue such as tissue of a papillary muscle. Each anchor may have a linear configuration for translation within the delivery catheter and a biased configuration that inhibits its reentry into the sling catheter once deployed. Once all anchors are deployed, the suture may be tightened, the anchored portion of the sling catheter may be detached, and the catheter system withdrawn.

Abstract: A kink-resistant hose comprises a tubing and at least one anti-kinking member disposed within an interior volume of the tubing. The outer diameter of the anti-kinking member is less than the inner diameter of the tubing, wherein the anti-kinking member and the tubing are coextruded such that the anti-kinking member is free-floating within the interior volume of the tubing. A cross-sectional area of the anti-kinking member is less than the area of a circle with diameter equal to the maximal diameter of the anti-kinking member. The anti-kinking member thereby defines propped open flow channels, extending radially between an outer surface of the anti-kinking member and an inner surface of the tubing at a kink point, for conveying fluid through a kink in the tubing. A restraint mechanism located in at least the first distal end of the tubing restrains longitudinal movement of the anti-kinking member through the tubing.

Abstract: An implantable medical device is adapted to be implanted at an implantation site such as a native cardiac valve annulus. The implantable medical device includes an expandable frame that is adapted to expand from a collapsed configuration for delivery to an expanded configuration for deployment, one or more valve cusps secured relative to the expandable frame, an inner skirt surrounding a portion of the expandable frame, and an outer skirt surrounding a portion of the expandable frame, the outer skirt attached to the expandable frame via one or more sutures that axially secure the outer skirt relative to the expandable frame yet allow the outer skirt to move radially relative to the expandable frame. The outer skirt may move radially outwards in response to fluid pressure, thereby improving fluid sealing relative to the native cardiac valve annulus.